Results 41 to 50 of about 1,200,697 (382)

Intratumoral immunotherapy with TLR7/8 agonist MEDI9197 modulates the tumor microenvironment leading to enhanced activity when combined with other immunotherapies

Journal of Immunotherapy for Cancer, 2019
BackgroundImmune checkpoint blockade (ICB) promotes adaptive immunity and tumor regression in some cancer patients. However, in patients with immunologically “cold” tumors, tumor-resident innate immune cell activation may be required to prime an adaptive
Stefanie R. Mullins, J. Vasilakos, Katharina Deschler, Iwen F. Grigsby, P. Gillis, J. John, Matthew J. Elder, J. Swales, Elina Timosenko, Z. Cooper, S. Dovedi, A. Leishman, Nadia Luheshi, James Elvecrog, Ashenafi Y Tilahun, R. Goodwin, R. Herbst, M. Tomai, R. Wilkinson   +18 more
semanticscholar   +1 more source

A photoisomerizable muscarinic antagonist. Studies of binding and of conductance relaxations in frog heart [PDF]

, 1982
These experiments employ the photoisomerizable compound, 3,3'-bis- [alpha-(trimethylammonium)methyl]azobenzene (Bis-Q), to study the response to muscarinic agents in frog myocardium. In homogenates from the heart, trans-Bis-Q blocks the binding of [3H]-N-
Birdsall, Nigel J. M., Erlanger, Bernard F., Lester, Henry A., Nargeot, Joel, Stockton, Jane, Wassermann, Norbert H.   +5 more
core   +1 more source

Improvement of irritable bowel syndrome with glucagon like peptide-1 receptor agonists: a systematic review and meta-analysis

Frontiers in Endocrinology
IntroductionIrritable bowel syndrome (IBS) is a severe gastrointestinal condition with symptoms like pain, bloating, diarrhea, and constipation. Glucagon-like peptide-1 (GLP-1) receptors, expressed in the central nervous system and peripheral tissues ...
Mohamed E. A. Mostafa, Tariq Alrasheed
doaj   +1 more source

Potential Adiponectin Receptor Response Modifier Therapeutics

Frontiers in Endocrinology, 2019
Many human diseases may benefit from adiponectin replacement therapy, but due to pharmacological disadvantages of the intact protein, druggable options focus on peptidic, and small molecule agonists of the adiponectin receptor.
Laszlo Otvos, Laszlo Otvos, Laszlo Otvos
doaj   +1 more source

STING agonist inflames the pancreatic cancer immune microenvironment and reduces tumor burden in mouse models

Journal of Immunotherapy for Cancer, 2019
Pancreatic cancer is characterized by an immune suppressive stromal reaction that creates a barrier to therapy. A murine transgenic pancreatic cancer cell line that recapitulates human disease was used to test whether a STimulator of Interferon Genes ...
Weiqing Jing, D. McAllister, Emily P. Vonderhaar, Katie A. Palen, Matthew J. Riese, J. Gershan, Bryon D. Johnson, M. Dwinell   +7 more
semanticscholar   +1 more source

Orexin-Corticotropin-Releasing Factor Receptor Heteromers in the Ventral Tegmental Area as Targets for Cocaine [PDF]

, 2015
Release of the neuropeptides corticotropin-releasing factor (CRF) and orexin-A in the ventral tegmental area (VTA) play an important role in stress-induced cocaine-seeking behavior.
Aguinaga, David, Cai, Ning-Sheng, Canela, Enric I, Casadó, Vicent, Cortés, Antonio, Ferré, Sergi, Hausch, Felix, Howell, Lesley A., Lluís, Carme, Mallol, Josefa, McCormick, Peter J., McDowell, Kimberly, Moreno, Estefanía, Moreno-Delgado, David, Navarro, Gemma, Quiroz, César, Rea, William, Sierakowiak, Adam   +17 more
core   +1 more source

The effect of fruit smoothie supplementation on psychological distress and biomarkers among people with opioid dependence receiving opioid agonist therapy: a randomized controlled trial

BMC Medicine
Background Unhealthy diets are common among individuals with opioid dependence. While fruit- and vegetable-rich diets have shown mental health benefits, evidence is limited for those receiving opioid agonist therapy (OAT).
Elaheh Javadi Arjmand, Lise Margrete Thomassen, Karl Trygve Druckrey-Fiskaaen, Einar Furulund, Jørn Henrik Vold, Tesfaye Madebo, Rune Blomhoff, Jan Tore Daltveit, Hege Berg Henriksen, Fatemeh Chalabianloo, Kjell Arne Johansen, Torgeir Gilje Lid, Lars Thore Fadnes, the ATLAS4LAR study group   +13 more
doaj   +1 more source

DREADD Agonist 21 Is an Effective Agonist for Muscarinic-Based DREADDs in Vitro and in Vivo

ACS Pharmacology & Translational Science, 2018
Chemogenetic tools such as designer receptors exclusively activated by designer drugs (DREADDs) are routinely used to modulate neuronal and non-neuronal signaling and activity in a relatively noninvasive manner.
K. Thompson, Elham Khajehali, S. Bradley, Jovana S. Navarrete, Xi Ping Huang, Samuel T. Slocum, Jian Jin, Jing Liu, Y. Xiong, Reid H. J. Olsen, J. Diberto, Kristen M. Boyt, M. Pina, Dipanwita Pati, Colin Molloy, C. Bundgaard, P. Sexton, T. Kash, M. Krashes, A. Christopoulos, B. Roth, A. Tobin   +21 more
semanticscholar   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Agonist binding, agonist affinity and agonist efficacy at G protein‐coupled receptors [PDF]

British Journal of Pharmacology, 2008
Measurements of affinity and efficacy are fundamental for work on agonists both in drug discovery and in basic studies on receptors. In this review I wish to consider methods for measuring affinity and efficacy at G protein coupled receptors (GPCRs).
openaire   +2 more sources