Results 51 to 60 of about 1,083,474 (317)
Deoxyguanosine is a TLR7 agonist [PDF]
European Journal of Immunology, 2019 AbstractToll‐like receptor 7 (TLR7) is an innate immune sensor for single‐strand RNA (ssRNA). Recent structural analysis revealed that TLR7 has an additional binding site for nucleosides such as guanosine, and is activated when both guanosine and ssRNA bind.
Jan Rehwinkel +4 more
openaire +3 more sources
A covalently bound photoisomerizable agonist. Comparison with reversibly bound agonists at electrophorus electroplaques [PDF]
, 1980 After disulphide bonds are reduced with dithiothreitol, trans-3-(alpha-bromomethyl)-3’-[alpha-(trimethylammonium)methyl]azobenzene (trans-QBr) alkylates a sulfhydryl group on receptors.
Erlanger, Bernard F. +4 more
core +2 more sources
Journal of Immunotherapy for Cancer, 2019 Pancreatic cancer is characterized by an immune suppressive stromal reaction that creates a barrier to therapy. A murine transgenic pancreatic cancer cell line that recapitulates human disease was used to test whether a STimulator of Interferon Genes ...
Weiqing Jing +7 more
semanticscholar +1 more source
RGS4 regulates partial agonism of the M2 muscarinic receptor-activated K+ currents. [PDF]
, 2014 Partial agonists are used clinically to avoid overstimulation of receptor-mediated signalling, as they produce a submaximal response even at 100% receptor occupancy.
Chen, I-Shan +3 more
core +2 more sources
TLRs as a Promise Target Along With Immune Checkpoint Against Gastric Cancer
Frontiers in Cell and Developmental Biology, 2021 Gastric cancer (GC) is one of the most common cancers in the world, and the incidence of gastric cancer in Asia appears to increase in recent years. Although there is a lot of improvement in treatment approaches, the prognosis of GC is poor.
Lin Cui, Xiuqing Wang, Dekai Zhang
doaj +1 more source
Proopiomelanocortin Deficiency Treated with a Melanocortin-4 Receptor Agonist.
New England Journal of Medicine, 2016 Patients with rare defects in the gene encoding proopiomelanocortin (POMC) have extreme early-onset obesity, hyperphagia, hypopigmentation, and hypocortisolism, resulting from the lack of the proopiomelanocortin-derived peptides melanocyte-stimulating ...
Peter Kühnen +9 more
semanticscholar +1 more source
Agonists and Partial Agonists of Rhodopsin: Retinals with Ring Modifications [PDF]
Biochemistry, 2005 Activation of the visual pigment rhodopsin is initiated by isomerization of its retinal chromophore to the all-trans geometry, which drives the conformation of the protein to the active state. We have examined by FTIR spectroscopy the impact of a series of modifications at the ring of retinal on the activation process and on molecular interactions ...
Vogel, Reiner +4 more
openaire +4 more sources
Mechanistic insights into allosteric regulation of the A2A adenosine G protein-coupled receptor by physiological cations. [PDF]
, 2018 Cations play key roles in regulating G-protein-coupled receptors (GPCRs), although their mechanisms are poorly understood. Here, 19F NMR is used to delineate the effects of cations on functional states of the adenosine A2A GPCR.
Ernst, Oliver P +11 more
core +2 more sources
Frontiers in Pharmacology, 2023 Certain 4-substituted analogs of 1-(2,5-dimethoxyphenyl)isopropylamine (2,5-DMA) are psychoactive classical hallucinogens or serotonergic psychedelic agents that function as human 5-HT2A (h5-HT2A) serotonin receptor agonists.
Prithvi Hemanth +5 more
doaj +1 more source
Human Reproduction Update, 2017 BACKGROUND Most reviews of IVF ovarian stimulation protocols have insufficiently accounted for various patient populations, such as ovulatory women, women with polycystic ovary syndrome (PCOS) or women with poor ovarian response, and have included ...
C. Lambalk +7 more
semanticscholar +1 more source