Results 171 to 180 of about 339,684 (208)

Chemical disulfide mapping identifies an inhibitor cystine knot in the agouti signaling protein

FEBS Letters, 2007
The agouti signaling protein (ASIP) and its homolog, the agouti-related protein (AgRP), act as inverse agonists that control, respectively, pigmentation and metabolic function in mammals.
Glenn L Millhauser
exaly   +2 more sources

Some of the next articles are maybe not open access.

Related searches:

Peptoid mimics of agouti related protein

Bioorganic & Medicinal Chemistry Letters, 2003
The Agouti Related Protein (AGRP) is an endogenous antagonist of melanocortin-3 and -4 receptors, each of which plays a key role in body weight homeostasis. We designed a peptoid trimer based on AGRP 111-113 in which a single chiral atom is used to partially restrain the backbone structure. Peptoid 5 displaced both radiolabeled Nle4-alpha-MSH (IC(50)=3.
Darren A, Thompson, Biao-Xin, Chai, Hilary L E, Rood, Michael A, Siani, Nicholai R, Douglas, Ira, Gantz, Glenn L, Millhauser   +6 more
openaire   +2 more sources

Functional properties of an agouti signaling protein variant and characteristics of its cognate radioligand

American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 2001
Agouti signaling protein (ASIP), the human (h) homolog of agouti, is an endogenous melanocortin peptide antagonist. To date, characterization of this protein has been performed with recombinant protein only and without the availability of an ASIP/agouti ...
Ying-Kui Yang, Chris Dickinson, Ji-Yao Li   +2 more
exaly   +2 more sources

The agouti-related protein and body fatness in humans

International Journal of Obesity, 2003
The objective of this study was to examine the impact of a single nucleotide polymorphism (SNP) (-38C>T) in the promoter of the human agouti-related protein (hAgRP) gene on promoter affinity for transcription factors (TFs) and its possible association with body composition phenotypes.Electrophoretic mobility shift assays for the functional studies and ...
G, Argyropoulos, T, Rankinen, F, Bai, T, Rice, M A, Province, A S, Leon, J S, Skinner, J H, Wilmore, D C, Rao, C, Bouchard   +9 more
openaire   +2 more sources

Agouti-related protein is a mediator of diabetic hyperphagia

Regulatory Peptides, 2001
To explore the role of agouti-related protein (AGRP) in diabetic hyperphagia changes in hypothalamic AGRP mRNA levels were examined in diabetic rats. Rats rendered diabetic by streptozotocin displayed marked hyperglycemia (blood glucose 456.0+/-8.4 mg/dl versus 71.8+/-1.9 mg/dl) and hyperphagia (36.9+/-1.0 g/day versus 22.0+/-0.4 g/day), that was ...
S Y, Qu, Y K, Yang, J Y, Li, Q, Zeng, I, Gantz   +4 more
openaire   +2 more sources

Agouti-related protein: More than a melanocortin-4 receptor antagonist?

Peptides, 2005
It is well established that agouti-related protein (AGRP) can act as a competitive antagonist to proopiomelanocortin (POMC)-derived peptides at the melanocortin-4 receptor (MC4R), and that this homeostatic mechanism is important as a means of ...
A White
exaly   +2 more sources

Inverse agonist activity of agouti and agouti-related protein

Peptides, 2003
Agouti and agouti-related protein (AgRP) are endogenous antagonists of the melanocortin receptors (MCxR). Previous data showed that recombinant full-length agouti and a synthetic fragment of AgRP, AgRP (83-132), are inverse agonists at the MC1R and MC4R, respectively.
Biao-Xin, Chai, Richard R, Neubig, Glenn L, Millhauser, Darren A, Thompson, Pilgrim J, Jackson, Gregory S, Barsh, Chris J, Dickinson, Ji-Yao, Li, Yu-Mei, Lai, Ira, Gantz   +9 more
openaire   +2 more sources

Agouti Signaling Protein Stimulates Islet Amyloid Polypeptide (Amylin) Secretion in Pancreatic β-Cells

Experimental Biology and Medicine, 2001
Ectopic overexpression of the murine agouti gene results in yellow coat color, obesity, hyperinsulinemia, and type II diabetes. We have shown the human homologue of agouti (agouti signaling protein; ASP) to regulate human adipocyte metabolism and lipid ...
Bingzhong Xue, Michael B Zemel
exaly   +2 more sources

The Agouti-related protein and its role in energy homeostasis

Peptides, 2005
The melanocortin system plays an important role in the regulation of energy homeostasis. The Agouti-related protein (AGRP) is a natural antagonist of the action of alpha-melanocyte stimulating hormone (alpha-MSH) at the melanocortin receptors (MCR).
Adrian M, Stütz, Christopher D, Morrison, George, Argyropoulos   +2 more
openaire   +2 more sources

The gene structure and minimal promoter of the human agouti related protein

Gene, 2001
The murine agouti related protein (mAGRP) is upregulated in obese and diabetic mice and stimulates hyperphagia when administered intracerebroventricularly (i.c.v.) or when overexpressed in transgenic mice. The human ortholog, hAGRP, has been isolated and has similar molecular and physiological properties.
A M, Brown, D K, Mayfield, J, Volaufova, G, Argyropoulos   +3 more
openaire   +2 more sources