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Chronic CNS administration of Agouti-related protein (Agrp) reduces energy expenditure
International Journal of Obesity, 2003To investigate whether the Agouti-related protein (Agrp), the melanocortin receptor antagonist, alters oxygen consumption, as a measure of energy expenditure.A 7-day intracerebroventricular administration of Agrp (1 nmol/day) in rats.Oxygen consumption was determined in closed-circuit respirometers on days 1 and 8.
C J, Small +6 more
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Melanocortins and body weight regulation: Glucocorticoids, Agouti-related protein and beyond
European Journal of Pharmacology, 2011In the intervening three decades since Panksepp observed for the first time that centrally administered α-melanocyte stimulating hormone decreased food intake (Panksepp and Meeker, 1976), a wealth of data have accrued to firmly establish melanocortin signaling as a central regulator of food intake and fat mass.
Marcus P, Corander, Anthony P, Coll
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Molecular Interaction of Agouti Protein and Agouti-Related Protein with Human Melanocortin Receptors
Biochemistry, 1998Agouti protein and the Agouti-related protein (AGRP) are antagonists of the melanocortin-3 receptor and melanocortin-4 receptor. Both proteins contain 10 cysteines in the C-terminal domain arranged in five disulfide bonds. One possible arrangement of the disulfide bonds predicts an octapeptide loop, and the chemical properties of four residues within ...
M R, Tota +6 more
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Glucocorticoid positively regulate Agouti-related protein gene
Endocrine Abstracts, 2018Mitsuru Nishiyama +4 more
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Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor
Nature, 1994Wenbiao Chen +2 more
exaly
Antagonism of Central Melanocortin Receptors in Vitro and in Vivo by Agouti-Related Protein
Science, 1997Brent D Wilson, Gregory S Barsh
exaly