Results 161 to 170 of about 23,001 (200)

Role of Agouti-related protein in adrenal steroidogenesis

Molecular and Cellular Endocrinology, 2007
The levels of Agouti-related protein (AgRP) mRNA in the adrenal are second only to those in the hypothalamus, raising questions regarding its target binding sites and its specific role in adrenal steroidogenesis. We and others demonstrated the presence of a population of melanocortin receptor-4 (MC4R) positively coupled to steroidogenesis in adrenal ...
Mabrouka, Doghman, Yacine, Soltani, Valentine, Rebuffet, Danielle, Naville, Martine, Bégeot   +4 more
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Inverse agonist activity of agouti and agouti-related protein

Peptides, 2003
Agouti and agouti-related protein (AgRP) are endogenous antagonists of the melanocortin receptors (MCxR). Previous data showed that recombinant full-length agouti and a synthetic fragment of AgRP, AgRP (83-132), are inverse agonists at the MC1R and MC4R, respectively.
Biao-Xin, Chai, Richard R, Neubig, Glenn L, Millhauser, Darren A, Thompson, Pilgrim J, Jackson, Gregory S, Barsh, Chris J, Dickinson, Ji-Yao, Li, Yu-Mei, Lai, Ira, Gantz   +9 more
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Novel Agouti-Related-Protein-Based Melanocortin-1 Receptor Antagonist

Journal of Medicinal Chemistry, 2001
The melanocortin receptors are G-protein coupled receptors (GPCRs) that activate the cAMP signal transduction pathway and are stimulated by the melanocortin agonist alpha-melanocyte stimulating hormone (alpha-MSH). Members of these melanocortin receptors are antagonized by agouti (ASP) and agouti-related protein (AGRP), which are the only known ...
R, Thirumoorthy, J R, Holder, R M, Bauzo, N G, Richards, A S, Edison, C, Haskell-Luevano   +5 more
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The agouti-related protein and body fatness in humans

International Journal of Obesity, 2003
The objective of this study was to examine the impact of a single nucleotide polymorphism (SNP) (-38C>T) in the promoter of the human agouti-related protein (hAgRP) gene on promoter affinity for transcription factors (TFs) and its possible association with body composition phenotypes.Electrophoretic mobility shift assays for the functional studies and ...
G, Argyropoulos, T, Rankinen, F, Bai, T, Rice, M A, Province, A S, Leon, J S, Skinner, J H, Wilmore, D C, Rao, C, Bouchard   +9 more
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Agouti-related protein is a mediator of diabetic hyperphagia

Regulatory Peptides, 2001
To explore the role of agouti-related protein (AGRP) in diabetic hyperphagia changes in hypothalamic AGRP mRNA levels were examined in diabetic rats. Rats rendered diabetic by streptozotocin displayed marked hyperglycemia (blood glucose 456.0+/-8.4 mg/dl versus 71.8+/-1.9 mg/dl) and hyperphagia (36.9+/-1.0 g/day versus 22.0+/-0.4 g/day), that was ...
S Y, Qu, Y K, Yang, J Y, Li, Q, Zeng, I, Gantz   +4 more
openaire   +2 more sources

A novel radiofluorinated agouti-related protein for tumor angiogenesis imaging

Amino Acids, 2012
A novel protein scaffold based on the cystine knot domain of the agouti-related protein (AgRP) has been used to engineer mutants that can bind to the α(v)β(3) integrin receptor with high affinity and specificity. In the current study, an (18)F-labeled AgRP mutant (7C) was prepared and evaluated as a positron emission tomography (PET) probe for imaging ...
Han, Jiang, Sarah J, Moore, Shuanglong, Liu, Hongguang, Liu, Zheng, Miao, Frank V, Cochran, Yang, Liu, Mei, Tian, Jennifer R, Cochran, Hong, Zhang, Zhen, Cheng   +10 more
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The Agouti-related protein and its role in energy homeostasis

Peptides, 2005
The melanocortin system plays an important role in the regulation of energy homeostasis. The Agouti-related protein (AGRP) is a natural antagonist of the action of alpha-melanocyte stimulating hormone (alpha-MSH) at the melanocortin receptors (MCR).
Adrian M, Stütz, Christopher D, Morrison, George, Argyropoulos   +2 more
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Agouti-related protein: More than a melanocortin-4 receptor antagonist?

Peptides, 2005
It is well established that agouti-related protein (AGRP) can act as a competitive antagonist to proopiomelanocortin (POMC)-derived peptides at the melanocortin-4 receptor (MC4R), and that this homeostatic mechanism is important as a means of coordinating appetite with perceived metabolic requirement. However, there are clearly additional facets to the
Pritchard, Lynn E., White, Anne
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Central and peripheral interactions between the agouti-related protein and leptin

Biochemical and Biophysical Research Communications, 2004
The agouti-related protein (AgRP) is a powerful appetite modulator expressed in the hypothalamus and the adrenal gland and regulated by leptin. Here we report the robust expression of AgRP in epididymal fat and its upregulation in this tissue by feeding rather than by fasting.
Chantal, Charbonneau, Fulu, Bai, Brenda Smith, Richards, George, Argyropoulos   +3 more
openaire   +2 more sources

Treadmill Exercise’s Reduction of Agouti-Related Protein Expression in Rat Liver

International Journal of Sport Nutrition and Exercise Metabolism, 2009
Agouti-related protein (AGRP) is an orexigenic peptide secreted from the arcuate nucleus (ARC) of the hypothalamus. AGRP increases food intake and plays a role in energy balance, adiposity, weight gain, and growth-hormone release. The objective of the current study was to examine the effects of running exercise on resting hepatic, fundus, and pancreas ...
Abbass, Ghanbari-Niaki, Rozita, Fathi, Sayed Alireza Hossaini, Kakhak, Zhara, Farshidi, Sara, Barmaki, Fatemeh, Rahbarizadeh, Robert R, Kraemer   +6 more
openaire   +2 more sources