Results 161 to 170 of about 339,684 (208)
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Agouti‐Related Protein: Appetite or Reward?
Annals of the New York Academy of Sciences, 2003Abstract:Agouti‐related protein (AgRP) is an orexigenic peptide that acts as an antagonist of the melanocortin‐3 and ‐4 receptors in the hypothalamus. Studies suggest that the melanocortin and opioid systems interact in the control of ingestive behavior. Also, AgRP has been shown to especially increase intake of a palatable diet.
Pawel K Olszewski +2 more
exaly +3 more sources
Role of Agouti-related protein in adrenal steroidogenesis
Molecular and Cellular Endocrinology, 2007The levels of Agouti-related protein (AgRP) mRNA in the adrenal are second only to those in the hypothalamus, raising questions regarding its target binding sites and its specific role in adrenal steroidogenesis. We and others demonstrated the presence of a population of melanocortin receptor-4 (MC4R) positively coupled to steroidogenesis in adrenal ...
Mabrouka Doghman +2 more
exaly +3 more sources
Agouti Related Protein (AgRP) is Upregulated in Cushing's Syndrome [PDF]
Experimental and Clinical Endocrinology & Diabetes, 2005 Alpha melanocyte-stimulating hormone (alpha-MSH) is an agonist at the melanocortin 3 (MC3-R) and melanocortin 4 (MC4-R) receptors. Alpha-MSH stimulates corticosterone release from rat and human adrenal cells. Patients with Cushing's syndrome have elevated levels of serum alpha-MSH.
Dhillo, WS +8 more
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Agouti-related protein in the hypothalamic paraventricular nucleus: effect on feeding
Peptides, 2000Agouti-related protein (Agrp) is an endogenous melanocortin-4 receptor antagonist implicated in the regulation of food intake. Effects of Agrp on feeding under varying conditions were investigated. Agrp (10 to 100 pmol) was injected into the hypothalamic paraventricular nucleus of satiated (a.m. and p.m.
Michelle M Wirth, Silvia Q Giraudo
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Agouti-related protein in patients with acute and weight-restored anorexia nervosa
Psychological Medicine, 2011 BackgroundAn imbalance in appetite-regulating neuropeptides of the central nervous system has been associated with anorexia nervosa (AN), but the mechanisms of action are poorly understood. Agouti-related protein (AGRP), an orexigenic mediator of the hypothalamus, increases food intake and decreases energy expenditure in times of negative energy ...
J V, Merle +6 more
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Plasma agouti-related protein levels in women with anorexia nervosa
Psychoneuroendocrinology, 2006Agouti-related protein (AGRP) is the competitive antagonist of alpha-melanocyte stimulating hormone (alpha-MSH) located at melanocortin receptors 3 and 4 (MC3R and MC4R), and also acts as an MC4R inverse agonist. Hypothalamic AGRP controls food intake and body weight in rodents. It has also been found in human plasma.
Tatsuo Shimosawa +2 more
exaly +3 more sources
FEBS Letters, 1998 Chemical synthesis of Agouti proteins – Agouti and Agouti-related proteins – is complicated by their large size and by multiple cysteine residues located in the carboxyl terminal regions.
Wolfgang Sadee, E T Wei
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Endocrinology, 2003 Agouti-related protein (AGRP) is a naturally occurring antagonist of melanocortin. In mammals, central AGRP expression is restricted to the arcuate nucleus in which it plays a key role in the control of energy balance by antagonizing melanocortin effects
JOSÉ MIGUEL Cerdá-Reverter +2 more
exaly +3 more sources
A polymorphism in the agouti signalling protein (ASIP) is associated with decreased levels of mRNA
Pigment Cell & Melanoma Research, 2006 To date, a role for agouti signalling protein (ASIP) in human pigmentation has not been well characterized. It is known that agouti plays a pivotal role in the pigment switch from the dark eumelanin to the light pheomelanin in the mouse. However, because
Richard A Sturm
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