Results 141 to 150 of about 12,122 (173)

The agouti-related protein and body fatness in humans

International Journal of Obesity, 2003
The objective of this study was to examine the impact of a single nucleotide polymorphism (SNP) (-38C>T) in the promoter of the human agouti-related protein (hAgRP) gene on promoter affinity for transcription factors (TFs) and its possible association with body composition phenotypes.Electrophoretic mobility shift assays for the functional studies and ...
G, Argyropoulos, T, Rankinen, F, Bai, T, Rice, M A, Province, A S, Leon, J S, Skinner, J H, Wilmore, D C, Rao, C, Bouchard   +9 more
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Agouti-related protein is a mediator of diabetic hyperphagia

Regulatory Peptides, 2001
To explore the role of agouti-related protein (AGRP) in diabetic hyperphagia changes in hypothalamic AGRP mRNA levels were examined in diabetic rats. Rats rendered diabetic by streptozotocin displayed marked hyperglycemia (blood glucose 456.0+/-8.4 mg/dl versus 71.8+/-1.9 mg/dl) and hyperphagia (36.9+/-1.0 g/day versus 22.0+/-0.4 g/day), that was ...
S Y, Qu, Y K, Yang, J Y, Li, Q, Zeng, I, Gantz   +4 more
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Inverse agonist activity of agouti and agouti-related protein

Peptides, 2003
Agouti and agouti-related protein (AgRP) are endogenous antagonists of the melanocortin receptors (MCxR). Previous data showed that recombinant full-length agouti and a synthetic fragment of AgRP, AgRP (83-132), are inverse agonists at the MC1R and MC4R, respectively.
Biao-Xin, Chai, Richard R, Neubig, Glenn L, Millhauser, Darren A, Thompson, Pilgrim J, Jackson, Gregory S, Barsh, Chris J, Dickinson, Ji-Yao, Li, Yu-Mei, Lai, Ira, Gantz   +9 more
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The Agouti-related protein and its role in energy homeostasis

Peptides, 2005
The melanocortin system plays an important role in the regulation of energy homeostasis. The Agouti-related protein (AGRP) is a natural antagonist of the action of alpha-melanocyte stimulating hormone (alpha-MSH) at the melanocortin receptors (MCR).
Adrian M, Stütz, Christopher D, Morrison, George, Argyropoulos   +2 more
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Agouti Related Protein (AgRP) is Upregulated in Cushing's Syndrome

Experimental and Clinical Endocrinology & Diabetes, 2005
Alpha melanocyte-stimulating hormone (alpha-MSH) is an agonist at the melanocortin 3 (MC3-R) and melanocortin 4 (MC4-R) receptors. Alpha-MSH stimulates corticosterone release from rat and human adrenal cells. Patients with Cushing's syndrome have elevated levels of serum alpha-MSH.
Dhillo, WS, Gardiner, JV, Castle, L, Bewick, GA, Smith, KL, Meeran, K, Todd, JF, Ghatei, MA, Bloom, S. R.   +8 more
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Plasma agouti-related protein levels in women with anorexia nervosa

Psychoneuroendocrinology, 2006
Agouti-related protein (AGRP) is the competitive antagonist of alpha-melanocyte stimulating hormone (alpha-MSH) located at melanocortin receptors 3 and 4 (MC3R and MC4R), and also acts as an MC4R inverse agonist. Hypothalamic AGRP controls food intake and body weight in rodents. It has also been found in human plasma.
Junko, Moriya, Yoshiyuki, Takimoto, Kazuhiro, Yoshiuchi, Tatsuo, Shimosawa, Akira, Akabayashi   +4 more
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The gene structure and minimal promoter of the human agouti related protein

Gene, 2001
The murine agouti related protein (mAGRP) is upregulated in obese and diabetic mice and stimulates hyperphagia when administered intracerebroventricularly (i.c.v.) or when overexpressed in transgenic mice. The human ortholog, hAGRP, has been isolated and has similar molecular and physiological properties.
A M, Brown, D K, Mayfield, J, Volaufova, G, Argyropoulos   +3 more
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A novel radiofluorinated agouti-related protein for tumor angiogenesis imaging

Amino Acids, 2012
A novel protein scaffold based on the cystine knot domain of the agouti-related protein (AgRP) has been used to engineer mutants that can bind to the α(v)β(3) integrin receptor with high affinity and specificity. In the current study, an (18)F-labeled AgRP mutant (7C) was prepared and evaluated as a positron emission tomography (PET) probe for imaging ...
Han, Jiang, Sarah J, Moore, Shuanglong, Liu, Hongguang, Liu, Zheng, Miao, Frank V, Cochran, Yang, Liu, Mei, Tian, Jennifer R, Cochran, Hong, Zhang, Zhen, Cheng   +10 more
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Central and peripheral interactions between the agouti-related protein and leptin

Biochemical and Biophysical Research Communications, 2004
The agouti-related protein (AgRP) is a powerful appetite modulator expressed in the hypothalamus and the adrenal gland and regulated by leptin. Here we report the robust expression of AgRP in epididymal fat and its upregulation in this tissue by feeding rather than by fasting.
Chantal, Charbonneau, Fulu, Bai, Brenda Smith, Richards, George, Argyropoulos   +3 more
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Molecular Interaction of Agouti Protein and Agouti-Related Protein with Human Melanocortin Receptors

Biochemistry, 1998
Agouti protein and the Agouti-related protein (AGRP) are antagonists of the melanocortin-3 receptor and melanocortin-4 receptor. Both proteins contain 10 cysteines in the C-terminal domain arranged in five disulfide bonds. One possible arrangement of the disulfide bonds predicts an octapeptide loop, and the chemical properties of four residues within ...
M R, Tota, T S, Smith, C, Mao, T, MacNeil, R T, Mosley, L H, Van der Ploeg, T M, Fong   +6 more
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