Results 41 to 50 of about 21,307 (186)

Liver-specific expression of the agouti gene in transgenic mice promotes liver carcinogenesis in the absence of obesity and diabetes

Molecular Cancer, 2004
Background The agouti protein is a paracrine factor that is normally present in the skin of many species of mammals. Agouti regulates the switch between black and yellow hair pigmentation by signalling through the melanocortin 1 receptor (Mc1r) on ...
Kiefer Laura L, Klebig Mitchell L, Mynatt Randall L, Kuklin Alexander I, Wilkison William O, Woychik Richard P, Michaud Edward J   +6 more
doaj   +1 more source

Progress report on new epilepsy treatments: A summary of the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII). II. Treatments in more advanced clinical development

Epilepsia, EarlyView.
Abstract This article summarizes data for 13 investigational treatments for which at least preliminary seizure outcome data in patients with epilepsy were reported at the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices held in Madrid, Spain, on May 3–6, 2026.
Meir Bialer, Cecilie Johannessen Landmark, Matthias J. Koepp, Emilio Perucca, Piero Perucca, Torbjörn Tomson, H. Steve White, Elaine Wirrell   +7 more
wiley   +1 more source

Interactions of alpha-melanotropin and agouti on B16 melanoma cells: evidence for inverse agonism of agouti.

, 1997
alpha-Melanocyte-stimulating hormone (alpha-MSH, alpha-melanotropin) and agouti control the switch between eumelanin and pheomelanin synthesis in mammalian melanocytes.
Wilkison WO, Willard DH, Drozdz R, Siegrist W, Eberle AN, Cotti R   +5 more
core   +1 more source

Ovarian DNA Methylation in Agouti Mice [PDF]

, 2023
Polycystic ovary syndrome (PCOS) affects 1 in 10 females. PCOS may be caused by various environmental and genetic factors and presents abnormalities such as hyperandrogenism and infertility.
Scribano, Pauline
core  

Dystocia in a Captive Reared Agouti (Dasyprocta leporina) in Trinidad and Tobago, West Indies

Veterinary Sciences, 2020
Dystocia is a complication that occurs at parturition either due to foetal or maternal factors. This condition has been well studies in domesticated species. However, there is very little information on dystocia in the agouti (Dasyprocta leporina).
Kegan Romelle Jones, Kavita Ranjeeta Lall, Gary Wayne Garcia   +2 more
doaj   +1 more source

Melanism in peromyscus is caused by independent mutations in agouti. [PDF]

PLoS ONE, 2009
Identifying the molecular basis of phenotypes that have evolved independently can provide insight into the ways genetic and developmental constraints influence the maintenance of phenotypic diversity.
Evan P Kingsley, Marie Manceau, Christopher D Wiley, Hopi E Hoekstra   +3 more
doaj   +1 more source

Syncing Health Timing: Exploring the Interplay of Circadian Rhythms, Obesity, and Cardiovascular Diseases

Food Safety and Health, EarlyView.
Circadian rhythm disruption impairs metabolic regulation, appetite control, and vascular function, promoting obesity and cardiovascular diseases. Evidence highlights a bidirectional relationship where metabolic disorders further disturb circadian timing.
Ghizal Fatima, István Dalmadi, Anna Jánosi, Krisztina Takács, Eszter Halmy   +4 more
wiley   +1 more source

Agouti regulates adipocyte transcription factors

, 2001
Agouti is a secreted paracrine factor that regulates pigmentation in hair follicle melanocytes. Several dominant mutations cause ectopic expression of agouti, resulting in a phenotype characterized by yellow fur, adult-onset obesity and diabetes ...
Randall L. Mynatt, Jacqueline M. Stephens   +1 more
core   +1 more source

Wildlife temporal behaviors in response to human activity changes during and following COVID‐19 park closures

Wildlife Biology, EarlyView.
With urbanization reducing the amount of available wildlife habitat, and outdoor recreation increasing the human activity within wildlife habitats, it is important to understand the effects of human activity on animal behavior. This study examined how the reduction in human presence in urban parks in Gainesville, Florida, affected the temporal ...
Maya Fives, Matthew Hallett
wiley   +1 more source

Agouti taczanowskii

, 1982
Agouti taczanowskii (Stolzmann, 1865). Proc. Zool. Soc. Lond., 1865:161. TYPE LOCALITY: Ecuador, Andes. DISTRIBUTION: Mountains of Peru, Ecuador, Colombia, and N. W. Venezuela.
Kenneth E. Kinman, James H. Honacki, James W. Koeppl   +2 more
core   +1 more source