Results 1 to 10 of about 20,765 (154)

A systematic review and pharmacovigilance analysis of the risk of agranulocytosis associated with metamizole use [PDF]

Scientific Reports
Metamizole is an analgesic widely used after its introduction but later withdrawn in several countries due to the risk of agranulocytosis. Despite this, it remains frequently used worldwide.
Alessia Zinzi, Mario Gaio, Donatella Ruggiero, Consiglia Riccardi, Cecilia Cagnotta, Ciro Pentella, Annalisa Capuano, Concetta Rafaniello   +7 more
doaj   +2 more sources

Predicting clozapine-induced adverse drug reaction biomarkers using machine learning [PDF]

Scientific Reports
Clozapine is an atypical antipsychotic used for patients with treatment-resistant schizophrenia. This drug has serious adverse drug reactions (ADRs), including the risk of severe neutropenia (agranulocytosis).
John-Paul Cooper, Pierre Chue, Arno G. Siraki, Lusine Tonoyan   +3 more
doaj   +2 more sources

Ceftazidime‐Induced Agranulocytosis: A Case Report [PDF]

Clinical Case Reports
The most common adverse events associated with ceftazidime include hypersensitivity reactions, gastrointestinal disturbances, and transient abnormal liver function tests, whereas neutropenia is a rare complication.
Bingbin Dong, Xin Wu, Changbao Huang
doaj   +2 more sources

A case of idiosyncratic drug‐induced agranulocytosis because of sulbactam/ampicillin [PDF]

Journal of General and Family Medicine
Idiosyncratic drug‐induced agranulocytosis is a rare but life‐threatening condition that requires immediate medical intervention. Although sulbactam/ampicillin (SBT/ABPC) is a widely used antibiotic, no prior case reports of its associated ...
Kazuya Toda, Kaku Kuroda, Moe Kuroda, Kota Kawai, Yukihiro Sato   +4 more
doaj   +2 more sources

Pharmacogenetics of metamizole-induced agranulocytosis: a systematic review and drug regulation implications [PDF]

Frontiers in Pharmacology
IntroductionMetamizole (dipyrone) is a widely used analgesic and antipyretic, but its use has been restricted in some countries due to the risk of metamizole-induced agranulocytosis (MIA).
Giovana Fernanda Santos Fidelis, Carolina Dagli-Hernandez, Carolina Dagli-Hernandez, Romina P. Martinelli, Jefman Efendi Marzuki, Jefman Efendi Marzuki, Baharuddin Baharuddin, Qun-Ying Yue, Brian Edwards, Eder de Carvalho Pincinato, Patricia Moriel   +10 more
doaj   +2 more sources

HLA-DQB1 6672G>C (rs113332494) is associated with clozapine-induced neutropenia and agranulocytosis in individuals of European ancestry

Translational Psychiatry, 2021
The atypical antipsychotic clozapine is the only effective medication for treatment-resistant schizophrenia. However, it can also induce serious adverse drug reactions, including agranulocytosis and neutropenia.
Bettina Konte, James T. R. Walters, Dan Rujescu, Sophie E. Legge, Antonio F. Pardiñas, Dan Cohen, Munir Pirmohamed, Jari Tiihonen, Annette M. Hartmann, Jan P. Bogers, Jan van der Weide, Karen van der Weide, Anu Putkonen, Eila Repo-Tiihonen, Tero Hallikainen, Ed Silva, Oddur Ingimarsson, Engilbert Sigurdsson, James L. Kennedy, Patrick F. Sullivan, Marcella Rietschel, Gerome Breen, Hreinn Stefansson, Kari Stefansson, David A. Collier, Michael C. O’Donovan, Ina Giegling   +26 more
doaj   +1 more source

Distinctive pattern of neutrophil count change in clozapine-associated, life-threatening agranulocytosis

npj Schizophrenia, 2022
The wider use of clozapine is limited by the risk of agranulocytosis and the associated requirement for monitoring of neutrophil counts. We searched local electronic patient records for cases of agranulocytosis occurring during clozapine treatment during
David Taylor, Kalliopi Vallianatou, Eromona Whiskey, Olubanke Dzahini, James MacCabe   +4 more
doaj   +1 more source

Agranulocytosis induced by metamizole and its management with granulocyte growth factor [PDF]

Vojnosanitetski Pregled, 2005
Drug-induced agranulocytosis was defined as a severe selective neutropenia caused by an unexpected drug reaction. Metamizole was the most common nonopioid analgesic drug associated with agranulocytosis.
Čeleketić Dušica, Trpković Andreja, Cvetković Zorica   +2 more
doaj   +1 more source

Can propylthiouracil induce autoimmune-related immunotoxicity? [PDF]

Vojnosanitetski Pregled, 2022
Introduction. The use of propylthiouracil can be associated with mild adverse reactions, but severe complications such as agranulocytosis and vasculitis can also be seen.
Bajkin Ivana, Golubović Sonja, Ičin Tijana, Stepanović Kristina, Ilić Tatjana   +4 more
doaj   +1 more source

Chemotherapy-related agranulocytosis as a predictive factor for germline BRCA1 pathogenic variants in breast cancer patients: a retrospective cohort study

Swiss Medical Weekly, 2023
BACKGROUND: Carriers of germline pathogenic variants of the BRCA1 gene (gBRCA1) tend to have a higher incidence of haematological toxicity upon exposure to chemotherapy.
Noémie Lang, Aurélie Ayme, Chang Ming, Jean‑Damien Combes, Victor N. Chappuis, Alex Friedlaender, Aurélie Vuilleumier, José L. Sandoval, Valeria Viassolo, Pierre O. Chappuis, S. Intidhar Labidi-Galy   +10 more
doaj   +1 more source