Results 91 to 100 of about 7,077 (114)

AgRP neurons mediate activity-dependent development of oxytocin connectivity and autonomic regulation. [PDF]

Proc Natl Acad Sci U S A
Biddinger JE, Elson AET, Fathi PA, Sweet SR, Nishimori K, Ayala JE, Simerly RB.   +6 more
europepmc   +1 more source

Cellular and metabolic function of GIRK1 potassium channels expressed by arcuate POMC and NPY/AgRP neurons. [PDF]

Mol Cells
Choi Y, Yoo ES, Oh Y, Sohn JW.
europepmc   +1 more source

Upregulation of Xbp1 in NPY/AgRP neurons reverses diet-induced obesity and ameliorates leptin and insulin resistance. [PDF]

Neuropeptides
Ajwani J, Hwang E, Portillo B, Lieu L, Wallace B, Kabahizi A, He Z, Dong Y, Grose K, Williams KW.   +9 more
europepmc   +1 more source

Shank3 deficiency elicits autistic-like behaviors by activating p38α in hypothalamic AgRP neurons. [PDF]

Mol Autism
Wu S, Wang J, Zhang Z, Jin X, Xu Y, Si Y, Liang Y, Ge Y, Zhan H, Peng L, Bi W, Luo D, Li M, Meng B, Guan Q, Zhao J, Gao L, He Z.   +17 more
europepmc   +1 more source

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Cannabinoids drive feeding through AgRP neurons

Brain Research
The endocannabinoid system regulates energy balance and feeding behavior, primarily through cannabinoid type-1 receptors (CB1Rs). While CB1R activation is known to increase food intake, the role of agouti-related peptide (AgRP) neurons of the arcuate nucleus (ARC) in this process remains unclear.
Bayram Yilmaz
exaly   +4 more sources

mTORC1 signaling in Agrp neurons mediates circadian expression of Agrp and NPY but is dispensable for regulation of feeding behavior

Biochemical and Biophysical Research Communications, 2015
Orexigenic agouti-related protein/neuropeptide Y (Agrp/NPY) neurons and an orexigenic pro-opiomelanocortin (POMC) neurons of the hypothalamus regulate feeding behavior and energy homeostasis. An understanding of the molecular signaling pathways that regulate Agrp/NPY and POMC function could lead to novel treatments for metabolic disorders.
Michael N Hall
exaly   +5 more sources

Opioidergic Regulation of AgRP Neurons

Physiology, 2023
Opioids are generally known to promote hedonic consumption. Although much of the existing evidence is primarily based on studies in mesolimbic pathway, endogenous opioids and their receptors are widely expressed in hypothalamic appetite circuits; however, their role in homeostatic feeding remains unclear.
Deniz Atasoy, Nilufer Sayar Atasoy, Yavuz Yavuz, Connor Laule, Chunyang Dong, Hyojin Kim, Iltan Aklan, Lin Tian   +7 more
openaire   +1 more source

The NPY/AgRP neuron and energy homeostasis

International Journal of Obesity, 2001
Kennedy hypothesized nearly 50 y ago that negative feedback regulation of body fat stores involves hormones that circulate in proportion to adiposity and enter the brain, where they exert inhibitory effects on food intake and energy balance. Recent studies implicate leptin and insulin as 'adiposity signals' to the brain that promote negative energy ...
G J, Morton, M W, Schwartz
openaire   +2 more sources

NPY/AgRP neurons are not essential for feeding responses to glucoprivation

Peptides, 2007
Animals respond to hypoglycemia by eating and by stimulating gluconeogenesis. These responses to glucose deprivation are initiated by glucose-sensing neurons in the brain, but the neural circuits that control feeding behavior are not well established. Neurons in the arcuate region of the hypothalamus that express neuropeptide Y (NPY) and agouti-related
Serge, Luquet, Colin T, Phillips, Richard D, Palmiter   +2 more
openaire   +2 more sources