Results 121 to 130 of about 19,682 (247)

Structural Basis for the Recognition in an Idiotype-Anti-Idiotype Antibody Complex Related to Celiac Disease [PDF]

, 2014
Anti-idiotype antibodies have potential therapeutic applications in many fields, including autoimmune diseases. Herein we report the isolation and characterization of AIM2, an anti-idiotype antibody elicited in a mouse model upon expression of the celiac
Abdel-Azeim, Safwat, Caputo, Ivana, Cavallo, Luigi, Di Niro, Roberto, Oliva, Romina, Sblattero, Daniele, Vangone, Anna   +6 more
core   +4 more sources

AIM2 exacerbates hypoxic-ischemic brain damage in neonatal rats via promoting neuronal pyroptosis

Brain Research Bulletin
Background: Pyroptosis has been reported to play a pathogenic role in neonatal hypoxic-ischemic brain damage (HIBD). Absence in melanoma 2 (AIM2) is an inflammasome involved in pyroptosis.
Qianqian Li, Zengqin Wang, Fengli Li, Songlin Liu, Yuhong Ding, Junmei Yan, Xing Feng, Mei Li   +7 more
doaj   +1 more source

AIM2 Mediates Inflammation-Associated Renal Damage in Hepatitis B Virus-Associated Glomerulonephritis by Regulating Caspase-1, IL-1β, and IL-18

Mediators of Inflammation, 2014
Background & Aims. AIM2 plays an important role in innate immunity, but its role in regulating the immune response to hepatitis B virus (HBV) is unknown.
Junhui Zhen, Le Zhang, Jiachao Pan, Shumin Ma, Xiaojian Yu, Xiaobo Li, Shijun Chen, Wenjun Du   +7 more
doaj   +1 more source

The DNA Sensor AIM2 Maintains Intestinal Homeostasis via Regulation of Epithelial Antimicrobial Host Defense

Cell Reports, 2015
Microbial pattern molecules in the intestine play immunoregulatory roles via diverse pattern recognition receptors. However, the role of the cytosolic DNA sensor AIM2 in the maintenance of intestinal homeostasis is unknown.
Shuiqing Hu, Lan Peng, Youn-Tae Kwak, Erin McElvania Tekippe, Chandrashekhar Pasare, James S. Malter, Lora V. Hooper, Md. Hasan Zaki   +7 more
doaj   +1 more source

Longitudinal change of serum AIM2 levels after aneurysmal subarachnoid hemorrhage and its prognostic significance: a two-center prospective cohort study

Scientific Reports
Absent in melanoma 2 (AIM2) is implicated in neuroinflammation. Here, we explored the prognostic significance of serum AIM2 in human aneurysmal subarachnoid hemorrhage (aSAH).
Ziyin Chen, Shengdong Zou, Hao Shan, Jin Liu, Da Tian, Xiaoyu Wu, Quan Du, Xiaoqiao Dong, Dingbo Yang   +8 more
doaj   +1 more source

Cytoplasmic localization of the interferon‐inducible protein that is encoded by the AIM2 (absent in melanoma) gene from the 200‐gene family [PDF]

, 2000
Vinay Choubey, Scott Walter, Yanbiao Geng, Xin Hong   +3 more
openalex   +1 more source

Roles of a novel splice variant of human IFI16 in innate immune response [PDF]

, 2014
Poster Presentation - Theme 4: Infection & immunityDNA from viral or bacterial pathogens activates innate immune response. The recognition of self-DNA would induce autoimmune diseases such as systemic lupus erythematosus (SLE).
Jin, D, Kok, KH, Siu, KL, Wang, P, Yang, W, Zhang, Y   +5 more
core  

On some non-conformal fractals

, 2010
This paper presents a simple method of calculating the Hausdorff dimension for a class of non-conformal ...
Gui Y, Gui Y, Luzia N, Michał Rams, Nielsen O A, Reeve H   +5 more
core   +1 more source

Stem cell-derived exosomes prevent the development of thoracic aortic aneurysm/dissection by inhibiting AIM2 inflammasome and pyroptosis

Extracellular Vesicle
Thoracic aortic aneurysm/dissection (TAAD) is a severe vascular condition associated with life-threatening complications, and its underlying molecular mechanisms remain largely unexplored.
Lin Lu, Feng Liu, Weiliang Wu, Yu Zhang, Bin Liu, Qingfang Han, Tonggan Lu, Huiling Zhang, Xi-yong Yu, Yangxin Li   +9 more
doaj   +1 more source

Bases moleculares de los inflamasomas: implicaciones patológicas [PDF]

, 2016
Esta revisión bibliográfica llevada a cabo, nos acerca hacia varios conceptos relativos a diferentes mecanismos que se suceden en las células y que pueden dar lugar a la muerte de la misma. Esto se sucede debido a la plataforma molecular estudiada aquí,
Pérez Márquez, Carlos
core