Results 121 to 130 of about 22,661 (290)

Sevoflurane attenuates cardiomyocyte apoptosis by mediating the miR-219a/AIM2/TLR4/MyD88 axis in myocardial ischemia/reperfusion injury in mice [PDF]

, 2020
Yan Li, Na Xing, Jingjing Yuan, Jianjun Yang   +3 more
openalex   +1 more source

Hepatocyte‐Derived Extracellular Vesicles Deliver miR‐328‐3p to Trigger PP2A‐B56δ–Mediated p‐NLRP3S295‐Dependent Metaflammation in Macrophages upon Microcystin‐LR Exposure

Advanced Science, Volume 13, Issue 6, 30 January 2026.
Hepatocyte‐derived extracellular vesicles deliver miR‐328‐3p to trigger PP2A‐B56δ–mediated p‐NLRP3S295‐dependent metaflammation in macrophages upon microcystin‐LR exposure. 2‐DG, 2‐deoxy‐D‐glucose. B56δ, protein phosphatase 2A‐B56δ. ER, endoplasmic reticulum. iHD‐EV, inducible hepatocyte‐derived extracellular vesicles. IP3R, inositol 1,4,5‐triphosphate
Jia‐Shen Wu, Xin‐Yu Zhang, Xin‐Yu Ma, Yue‐Yue Wei, Lei‐Lei Wang, Ze‐Bang Du, Xiao‐Gang Xia, Lin Che, Dong‐Bei Guo, Han‐Ying Zheng, You‐Liang Yao, Wen‐Gang Li, Yu‐Chun Lin, Zhong‐Ning Lin   +13 more
wiley   +1 more source

Usability of serum AIM2 as a predictive biomarker of stroke-associated pneumonia and poor prognosis after acute supratentorial intracerebral hemorrhage: A prospective longitudinal cohort study

Heliyon
Background: Absent in melanoma 2 (AIM2) is implicated in inflammatory processes. We measured serum AIM2 with intent to unveil its predictive significance for stroke-associated pneumonia (SAP) and functional prognosis following acute intracerebral ...
Chengliang Zhang, Chuanliu Wang, Ming Yang, Han Wen, Ping Li   +4 more
doaj   +1 more source

Novel role of PKR in inflammasome activation and HMGB1 release [PDF]

, 2014
The inflammasome regulates release of caspase activation-dependent cytokines, including IL-1β, IL-18, and high-mobility group box 1 (HMGB1)1-5. During the course of studying HMGB1 release mechanisms, we discovered an important role of double-stranded RNA
Andersson, Ulf, Antoine, Daniel J., Chavan, Sangeeta S., Erlandsson-Harris, Helena, Hotamisligil, Gökhan S., Inouye, Karen, Kalb, Thomas, Li, Jianhua, Lu, Ben, Lundbäck, Peter, Nakamura, Takahisa, Olofsson, Peder S., Roth, Jesse, Tang, Yiting, Ting, Jenny P-Y, Tracey, Kevin J., Valdes-Ferrer, Sergio I, Wang, Haichao, Yang, Huan, Zou, Yongrui   +19 more
core   +1 more source

Epigallocatechin gallate prevents cardiomyocytes from pyroptosis through lncRNA MEG3/TAF15/AIM2 axis in myocardial infarction [PDF]

, 2023
Chaoshi Qin, Tingting Wang, Ni Qian, Jing Liu, Xi Rong, Qing Zou, Hui Liu, Xiaolin Niu   +7 more
openalex   +1 more source

USP11‐PGAM5 Axis Promotes Neurotoxic Astrocyte Reactivity by Aggravating the mtDNA‐cGAS‐STING Pathway After Intracerebral Hemorrhage

Advanced Science, Volume 13, Issue 1, 5 January 2026.
This study reveals that the deubiquitinase USP11 stabilizes PGAM5, triggering neurotoxic astrocyte transformation after intracerebral hemorrhage. PGAM5 promotes mPTP opening and Drp1 dephosphorylation, synergistically amplifying mtDNA leakage into the cytosol and leading to cGAS–STING hyperactivation.
Jiaqing He, Zijuan Qin, Yaning Cai, Haixiao Liu, Tinghao Wang, Qing Hu, Yanni Xu, Pan Yang, Xun Wu, Yan Qu, Wei Guo   +10 more
wiley   +1 more source

OM-85 is an immunomodulator of interferon-β production and inflammasome activity. [PDF]

, 2017
The inflammasome-IL-1 axis and type I interferons (IFNs) have been shown to exert protective effects upon respiratory tract infections. Conversely, IL-1 has also been implicated in inflammatory airway pathologies such as asthma and chronic obstructive ...
Dang, A.T., Guarda, G., Ludigs, K., Pasquali, C.   +3 more
core   +1 more source

T Cell Exhaustion and Dendritic Cell‐Mediated Tertiary Lymphoid Structures (TLSs) Modulation Affect Response to Neoadjuvant Chemoradiotherapy in Microsatellite Stable Rectal Cancer

Advanced Science, Volume 13, Issue 4, 19 January 2026.
Using multi‐omics analysis, this study demonstrates that immune characteristics of the tumor microenvironment, rather than mutational profiles, are more strongly correlated with treatment response. Specifically, early exhausted T cells and tertiary lymphoid structures regulation by LAMP3⁺ dendritic cells emerge as key predictors of favorable outcomes ...
Miao Wang, Jiejun Shi, Kai Xu, Leyi Yu, Xiaomao Yin, Jiexuan Wang, Lin Zhu, Xin Yang, Jingjing Qian, Wenqiang Wang, Liangchen Zhu, Xuan Dai, Zekun Zhao, Jinran Wu, Dongsheng Li, Zhiqian Hu, Qi Huang, Xinxing Li   +17 more
wiley   +1 more source

EIF2AK2 protein targeted activation of AIM2-mediated PANoptosis promotes sepsis-induced acute kidney injury

Renal Failure
Background Acute kidney injury (AKI) frequently occurs as a complication of sepsis. PANoptosis refers to a type of inflammatory programmed cell death that exhibits key characteristics of apoptosis, necroptosis, and pyroptosis. Here, we evaluated the role
Siwei Wei, Lei Wu, Zhen Xiang, Xiaoxiao Yang, Dongjie Pei, Liubing Jiang, Zhen Du   +6 more
semanticscholar   +1 more source

Investigation into the Pancreatic Pathogenesis of SFTSV across Multiple Levels

Advanced Science, Volume 13, Issue 1, 5 January 2026.
A retrospective analysis revealed that 17.6% of severe fever with thrombocytopenia syndrome (SFTS) patients met the diagnostic criteria for clinically confirmed pancreatitis. Using human pancreatic organoids and murine models demonstrated that SFTSV exhibits a specific pancreatic tropism, leading to cell death and initiating a strong inflammatory ...
Xiaohan Liu, Zhihao Xu, Yilun Tong, Changtai Wang, Yueqi Yao, Yujie Diao, Jingyuan Ma, Shijun Zhou, Yinan Du, Zhenhua Zhang, Gang Xu   +10 more
wiley   +1 more source