Results 141 to 150 of about 19,682 (247)

New insights into nucleic acid sensor AIM2: The potential benefit in targeted therapy for cancer

Pharmacological Research
The AIM2 inflammasome represents a multifaceted oligomeric protein complex within the innate immune system, with the capacity to perceive double-stranded DNA (dsDNA) and engage in diverse physiological reactions and disease contexts, including cancer ...
Jian-Zhou Cui, Zhi Huan Chew, Lina H.K. Lim   +2 more
doaj   +1 more source

Nucleic acid sensors and programmed cell death [PDF]

, 2020
Liverpool, Layal, Maelfait, Jonathan, Rehwinkel, Jan   +2 more
core   +2 more sources

Mitokondriális eredetű nitrogén szabadgyökök és ATP-függő K-csatornák szerepe az organellum működésében = The involvement of mitochondrial-derived nitrogen radicals and mitoK-ATP channels in the regulation of organelle function [PDF]

, 2009
Elsőként a mitoKATP csatornák alegységeit terveztük azonosítani humán szív mintákon. A kísérletek során megbizonyosodtunk afelől, hogy a korábban ilyen csatornáknak gondolt fehérjék nincsenek jelen megfelelő számban és formában a mitokondriális ...
Csordás, Attila, Horváth, Eszter Mária, Lacza, Zsombor, Pankotai, Eszter, Szabó, Csaba   +4 more
core  

Activation of NLRP3 and AIM2 inflammasomes in Kupffer cells in hepatic ischemia/reperfusion [PDF]

, 2014
Hyo‐Yeon Kim, Seok‐Joo Kim, Sun‐Mee Lee   +2 more
openalex   +1 more source

Neutrophil extracellular traps facilitate liver inflammation/fibrosis progression by entering macrophages and triggering AIM2 inflammasome-dependent pyroptosis

Cell Communication and Signaling
Background Absent in melanoma 2 (AIM2) inflammasome-dependent pyroptosis and neutrophil extracellular traps (NETs) have been implicated in chronic liver disease (CLD).
Yu Zhang, Rong Wu, Xi Zhan, Xuan-Yi Wang, Lin-Wei Xiang, Ya-Qian Duan, Yan You, Jian-Bo Zhang, Rui Wu, Yun-Yuan Zhang, Liang Duan   +10 more
doaj   +1 more source

AIM2 Blocks Colon Cancer in Three Ways [PDF]

, 2015

openalex   +1 more source

Assembly-driven activation of the AIM2 foreign-dsDNA sensor provides a polymerization template for downstream ASC [PDF]

, 2015
Seamus R. Morrone, Mariusz Matyszewski, Xiong Yu, Michael Delannoy, Edward H. Egelman, Jungsan Sohn   +5 more
openalex   +1 more source

A novel role of AIM2 inflammasome-mediated pyroptosis in radiofrequency ablation of hepatocellular carcinoma

Annals of Hepatology
Introduction and Objectives: The absence of melanoma 2 (AIM2) protein triggers the activation of the inflammasome cascade. It is unclear whether AIM2 plays a role in hepatocellular carcinoma (HCC) and radiofrequency ablation (RFA), which uses ...
Feifan He, Zhongming He, Caoye Wang
doaj   +1 more source

A keratinociták, szebociták, és a Propionibacterium acnes baktérium közötti kölcsönhatások in vitro modellezése [PDF]

, 2014
Bőrünk jellegzetes mikrobiális flórával rendelkezik, mely a bőr felső rétegeiben, illetve a piloszebáceus egység (follikulus) területén helyezkedik el. Az itt található sejtek (keratinociták, szebociták) valamint a mikróbák közötti komplex kölcsönhatás ...
Bolla, Beáta Szilvia, Erdei, Lilla, Glasenhardt, Katalin, Kemény, Lajos, Szabó, Kornélia, Tax, Gábor, Urbán, Edit   +6 more
core  

The Role of the AIM2 Gene in Obesity-Related Glucose and Lipid Metabolic Disorders: A Recent Update

Diabetes, Metabolic Syndrome and Obesity
Yongjiao Zhang,1,2 Xiaolei Xuan,2 Diwen Ye,1,2 Dong Liu,2 Yufan Song,2 Fei Gao,2 Sumei Lu2 1School of Medical Laboratory, Shandong Second Medical University, Weifang, Shandong, People’s Republic of China; 2Department of Laboratory Medicine, The First ...
Zhang Y, Xuan X, Ye D, Liu D, Song Y, Gao F, Lu S   +6 more
doaj