Results 151 to 160 of about 22,661 (290)

Cytosolic DNA sensor AIM2 promotes KRAS‐driven lung cancer independent of inflammasomes

Cancer Science
Constitutively active KRAS mutations are among the major drivers of lung cancer, yet the identity of molecular co‐operators of oncogenic KRAS in the lung remains ill‐defined.
Mohammad Alanazi, Teresa Weng, L. McLeod, L. Gearing, Julian A. Smith, Beena Kumar, Mohamed I Saad, Brendan J Jenkins   +7 more
semanticscholar   +1 more source

Human Cytomegalovirus Immediate Early 86-kDa Protein Blocks Transcription and Induces Degradation of the Immature Interleukin-1β Protein during Virion-Mediated Activation of the AIM2 Inflammasome [PDF]

, 2019
Sara Botto, Jinu Abraham, Nobuyo Mizuno, Kara Pryke, Bryan Gall, Igor Landais, Daniel N. Streblow, Klaus Früh, Victor R. DeFilippis   +8 more
openalex   +1 more source

AIM2 upregulation promotes metastatic progression and PD‐L1 expression in lung adenocarcinoma

, 2022
Jing‐Quan Zheng, Che‐Hsuan Lin, H Lee, Wei‐Min Chang, Lijie Li, Chia‐Yi Su, Kang‐Yun Lee, Hui‐Wen Chiu, Yuan‐Feng Lin   +8 more
openalex   +1 more source

Low‐Dose Chemotherapy Preferentially Shapes the Ileal Microbiome and Augments the Response to Immune Checkpoint Blockade by Activating AIM2 Inflammasome in Ileal Epithelial Cells

Advancement of science
Intervention of the gut microbiome is a promising adjuvant strategy in cancer immunotherapy. Chemotherapeutic agents are recognized for their substantial impacts on the gut microbiome, yet their therapeutic potential as microbiome modulators remains ...
Congying Pu, Yize Li, Yixian Fu, Yiyang Yan, Siyao Tao, Shuai Tang, X. Gai, Ziyi Ding, Zhenjie Gan, Yingluo Liu, Siyuwei Cao, Ting Wang, Jian Ding, Jun Xu, Meiyu Geng, Min Huang   +15 more
semanticscholar   +1 more source

Bases moleculares de los inflamasomas: implicaciones patológicas [PDF]

, 2016
Esta revisión bibliográfica llevada a cabo, nos acerca hacia varios conceptos relativos a diferentes mecanismos que se suceden en las células y que pueden dar lugar a la muerte de la misma. Esto se sucede debido a la plataforma molecular estudiada aquí,
Pérez Márquez, Carlos
core  

Nucleic acid sensors and programmed cell death [PDF]

, 2020
Liverpool, Layal, Maelfait, Jonathan, Rehwinkel, Jan   +2 more
core   +2 more sources

Identificación de nuevos agentes reguladores del inflamasoma: posibilidades para el desarrollo de fármacos antiinflamatorios [PDF]

, 2018
El contenido de esta revisión parte de un conocimiento global sobre el inflamasoma. Comenzando por los receptores de reconocimiento de patrones o PRR, que pueden tener una localización transmembranal o bien en orgánulos intracelulares.
Martín Marín, Lara
core  

Tyrosine Dephosphorylation of ASC Modulates the Activation of the NLRP3 and AIM2 Inflammasomes [PDF]

, 2019
Bezaleel Mambwe, Kurt Neo, Hanif Javanmard Khameneh, Keith Weng Kit Leong, Mariasilvia Colantuoni, Maurizio Vacca, Richmond Muimo, Alessandra Mortellaro   +7 more
openalex   +1 more source

AIM2 Nuclear Exit and Inflammasome Activation in Chronic Obstructive Pulmonary Disease and Response to Cigarette Smoke  [PDF]

, 2020
Hai B. Tran, Rhys Hamon, Hubertus Jersmann, Miranda P. Ween, Patrick Asare, Rainer Haberberger, Harshita Pant, Sandra Hodge   +7 more
openalex   +1 more source

Wogonin upregulates SOCS3 to alleviate the injury in Diabetic Nephropathy by inhibiting TLR4-mediated JAK/STAT/AIM2 signaling pathway

Molecular Medicine
Diabetic nephropathy (DN) is a life-threatening renal disease and needs urgent therapies. Wogonin is renoprotective in DN. This study aimed to explore the mechanism of how wogonin regulated high glucose (HG)-induced renal cell injury.
Yufeng Liu, Mengbi Zhang, Lu Zeng, Yanhong Lai, Songzhao Wu, Xiaoyan Su   +5 more
semanticscholar   +1 more source