Results 231 to 240 of about 19,682 (247)

NLRP3 and AIM2 inflammasomes exacerbate the pathogenic Th17 cell response to eggs of the helminth Schistosoma mansoni. [PDF]

PLoS Pathog
Suresh Kumar Meena Kumari M, Liu P, Nitchman MS, Chaudhary S, Jump K, Morales Y, Miller EA, Shecter I, Stadecker MJ, Kalantari P.   +9 more
europepmc   +1 more source

Novel diagnostic and therapeutic strategies based on PANoptosis for hepatocellular carcinoma. [PDF]

Cancer Biol Med
Xiang J, Li Y, Mei S, Ou Z, Wang L, Ke Y, Li Z.   +6 more
europepmc   +1 more source

Distinct Inflammatory Responses of hiPSC-Derived Endothelial Cells and Cardiomyocytes to Cytokines Involved in Immune Checkpoint Inhibitor-Associated Myocarditis. [PDF]

Cells
Conte S, Firoaguer I, Lledo S, Tran TT, El Yazidi C, Simoncini S, Rebaoui Z, Guiol C, Chevillard C, Guieu R, Puthier D, Thuny F, Cautela J, Lalevée N.   +13 more
europepmc   +1 more source

Edaravone dexborneol protected neurological function by targeting NRF2/ARE and NF-κB/AIM2 pathways in cerebral ischemia/reperfusion injury. [PDF]

Front Pharmacol
Zhang H, Zhu C, Zhou X, Wang L, Deng L, He B, Li J.   +6 more
europepmc   +1 more source

Absent in melanoma 2: a potent suppressor of retinal pigment epithelial-mesenchymal transition and experimental proliferative vitreoretinopathy. [PDF]

Cell Death Dis
Chen Y, Jiang M, Li L, Yang S, Liu Z, Lin S, Wang W, Li J, Chen F, Hou Q, Ma X, Hou L.   +11 more
europepmc   +1 more source

Transcriptional Consequences of MeCP2 Knockdown and Overexpression in Mouse Primary Cortical Neurons. [PDF]

Int J Mol Sci
Rezapour M, Bowser J, Richardson C, Gurcan MN.   +3 more
europepmc   +1 more source

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Taking AIM2 at atherosclerotic plaques

Nature Reviews Drug Discovery, 2021
Clonal haematopoiesis — an expansion of blood cell clones due to advantageous somatic mutations — is linked to myocardial infarction. A new study shows that activation of the AIM2 inflammasome in clonally expanded macrophages exacerbates atherosclerosis by driving both proliferation and pyroptosis.
openaire   +4 more sources

Neutrophil extracellular traps promote keratinocyte inflammation via AIM2 inflammasome and AIM2‐XIAP in psoriasis

Experimental Dermatology, 2022
AbstractThe infiltration of neutrophils in the epidermis and the release of neutrophil extracellular traps (NETs) are important events in the pathogenesis of psoriasis, but the regulatory roles and internal mechanism of NETs in psoriasis are largely unknown.
Tianyu Cao, Xu Yuan, Hui Fang, Jiaoling Chen, Ke Xue, Zhiguo Li, Erle Dang, Gang Wang, Shuai Shao   +8 more
openaire   +2 more sources

HPV16 activates the AIM2 inflammasome in keratinocytes

Archives of Dermatological Research, 2013
Human papillomaviruses (HPV) are double-stranded DNA viruses, which selectively infect keratinocytes in stratified epithelia. After an initial infection, many patients clear HPV. In some patients, however, HPV persist, and dysfunctional innate immune responses to HPV infection could be involved in the ineffective clearing of these viruses.
Reinholz, M, Kawakami, Y, Salzer, S, Kreuter, A, Dombrowski, Y, Koglin, S, Kresse, S, Ruzicka, T, Schauber, J   +8 more
openaire   +3 more sources

AIM2 Inflammasome Assembly and Signaling

2019
AIM2 (absent in melanoma 2) is a cytoplasmic sensor of double-stranded DNA from pathogens or damaged cellular organelles. It recruits ASC (apoptosis-associated specklike protein containing a CARD) and caspase-1 to form the AIM2 inflammasome, activate caspase-1, and elicit inflammatory responses via cytokine maturation and pyroptotic cell death ...
Yuan Tian, Qian Yin, Bing Wang
openaire   +3 more sources