Results 241 to 247 of about 19,682 (247)

USP21 Deubiquitinase Regulates AIM2 Inflammasome Activation

The Journal of Immunology, 2021
Abstract Innate immune sensing of cytosolic DNA via absent in melanoma 2 (AIM2) is a key mechanism leading to inflammatory responses. As aberrant immune responses by dysregulated AIM2 are associated with autoinflammatory diseases, activation of the AIM2 inflammasome should be tightly controlled.
Yujin Hong, Seong-Ok Lee, Changhoon Oh, Kwonyoon Kang, Jeongmin Ryoo, Dongyoung Kim, Kwangseog Ahn   +6 more
openaire   +2 more sources

Investigating the Role of AIM2 in Lung Adenocarcinoma

2022
Lung cancer is the most lethal cancer worldwide. There are no effective therapies to cure this disease due to some reasons, including severe side effects and drug resistance. Thus, there is an urgent need to investigate further the underlying mechanisms of lung cancer to develop effective therapies for lung cancer patients.
openaire   +1 more source

The Influence of Radiotherapy on AIM2 Inflammasome in Radiation Pneumonitis

Inflammation, 2016
This study aims to investigate the influence of radiotherapy on absent in melanoma 2 (AIM2) inflammasome in radiation pneumonitis (RP). A rat model of RP was established. H&E staining was used to test radiation-induced lung tissue injury. Immunohistochemistry (IHC) was used to detect the expression of AIM2 and IL-1β in rat lung tissues. Milliplex assay
Qinyong Hu, Bin Xu, Qibin Song, Qianyu Zhang, Yuxin Chu   +4 more
openaire   +3 more sources

Impact of AIM2 on HNSCC Development

AbstractHead and neck squamous cell carcinoma (HNSCC) constitutes 90% of head and neck cancers. HNSCC development is linked to chronic inflammation, while established HNSCC tumors are often immune suppressive. However, both occur through mechanisms that are not fully understood. The cytosolic double-stranded DNA sensor Absent in Melanoma 2 (AIM2) is an
Dakota M. Reinartz, Vicente Escamilla-River, Stephanie L. Tribble, Carlos Caulin, Justin E. Wilson   +4 more
openaire   +2 more sources

Reconstituted AIM2 inflammasome in cell-free system

Journal of Immunological Methods, 2015
Absent in melanoma 2 (AIM2) is an intracellular pattern-recognition receptor, which is a member of the PYHIN protein family, consisting of a PYD domain and an IFN-inducible nuclear localization (HIN) domain. AIM2 is reported to oligomerize with adaptor protein ASC upon sensing bacterial and viral cytosolic DNA in order to form the AIM2 inflammasome ...
Kiyoshi Migita, Junya Masumoto, Mie Kurata, Sho Mokuda, Naoe Kaneko, Shinnosuke Morikawa, Tatsuya Sawasaki, Atsushi Kawakami, Yuki Ito, Hiroyuki Takeda, Tomoyuki Iwasaki, Kazunaga Agematsu   +11 more
openaire   +3 more sources

The absent in melanoma 2 (AIM2) inflammasome in microbial infection

Clinica Chimica Acta, 2019
Inflammasomes play a very important role in the host defense against multiple pathogenic microbes, including bacteria and viruses. Inflammasomes are multiprotein complex platforms that mediate the processing of the two most important inflammatory cytokines, pro-IL-1β and pro-IL-18, to their active forms.
Wenbo Zhu, Xuyu Zu, Shuangquan Liu, Hongbo Zhang   +3 more
openaire   +3 more sources

[DDX10 promotes AIM2-inflammasome activation by maintaining AIM2 protein stability].

Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 2020
Objective To investigating the role of DEAD box helicase 10 (DDX10) in regulating absent in melanoma 2 (AIM2)-inflammasome activity. Methods HEK293T-caspase-1-ASC-IL-1β (HEK293T-CIA) cells were transiently co-transfected with expression vector carrying AIM2 and one of the 10 candidate genes encoding DDX family members. To screen candidate regulators of
Shanmeizi, Zhao, Meng, Lin, Yuxia, Zhang
openaire   +1 more source