Results 251 to 260 of about 22,661 (290)

Regulation of cancer by inflammasomes: from inflammation to tumorigenesis. [PDF]

Front Immunol
Malvankar S, Jaiswal P, Bhat PP, Mehto S.   +3 more
europepmc   +1 more source

Targeting DNA Damage and Repair Pathways in Cerebral Ischemic Stroke: From Bench to Bedside. [PDF]

Transl Stroke Res
Xie Z, Luo Y, Han Z.
europepmc   +1 more source

The role of AIM2 in inflammation and tumors

Frontiers in Immunology
Absent in melanoma 2 (AIM2) serves as an intracellular nucleic acid sensor that predominantly detects double-stranded DNA (dsDNA) within the cells. This detection initiates the assembly of inflammasome and activates the inflammasome signaling cascade ...
Dalang Yu, Siping Zheng, Lina Sui, Yuling Xi, Tiansheng He, Zhiping Liu   +5 more
semanticscholar   +4 more sources

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USP21 Deubiquitinase Regulates AIM2 Inflammasome Activation

The Journal of Immunology, 2021
Abstract Innate immune sensing of cytosolic DNA via absent in melanoma 2 (AIM2) is a key mechanism leading to inflammatory responses. As aberrant immune responses by dysregulated AIM2 are associated with autoinflammatory diseases, activation of the AIM2 inflammasome should be tightly controlled.
Yujin Hong, Seong-Ok Lee, Changhoon Oh, Kwonyoon Kang, Jeongmin Ryoo, Dongyoung Kim, Kwangseog Ahn   +6 more
openaire   +2 more sources

Neutrophil extracellular traps promote keratinocyte inflammation via AIM2 inflammasome and AIM2‐XIAP in psoriasis

Experimental Dermatology, 2022
AbstractThe infiltration of neutrophils in the epidermis and the release of neutrophil extracellular traps (NETs) are important events in the pathogenesis of psoriasis, but the regulatory roles and internal mechanism of NETs in psoriasis are largely unknown.
Tianyu Cao, Xu Yuan, Hui Fang, Jiaoling Chen, Ke Xue, Zhiguo Li, Erle Dang, Gang Wang, Shuai Shao   +8 more
openaire   +2 more sources

Taking AIM2 at atherosclerotic plaques

Nature Reviews Drug Discovery, 2021
Clonal haematopoiesis — an expansion of blood cell clones due to advantageous somatic mutations — is linked to myocardial infarction. A new study shows that activation of the AIM2 inflammasome in clonally expanded macrophages exacerbates atherosclerosis by driving both proliferation and pyroptosis.
openaire   +2 more sources

AIM2 Inflammasome Assembly and Signaling

2019
AIM2 (absent in melanoma 2) is a cytoplasmic sensor of double-stranded DNA from pathogens or damaged cellular organelles. It recruits ASC (apoptosis-associated specklike protein containing a CARD) and caspase-1 to form the AIM2 inflammasome, activate caspase-1, and elicit inflammatory responses via cytokine maturation and pyroptotic cell death ...
Bing, Wang, Yuan, Tian, Qian, Yin
openaire   +2 more sources

HPV16 activates the AIM2 inflammasome in keratinocytes

Archives of Dermatological Research, 2013
Human papillomaviruses (HPV) are double-stranded DNA viruses, which selectively infect keratinocytes in stratified epithelia. After an initial infection, many patients clear HPV. In some patients, however, HPV persist, and dysfunctional innate immune responses to HPV infection could be involved in the ineffective clearing of these viruses.
Reinholz, M, Kawakami, Y, Salzer, S, Kreuter, A, Dombrowski, Y, Koglin, S, Kresse, S, Ruzicka, T, Schauber, J   +8 more
openaire   +3 more sources