Results 261 to 270 of about 22,661 (290)

The histone lactylation of AIM2 influences the suppression of ferroptosis by ACSL4 through STAT5B and promotes the progression of lung cancer

The FASEB Journal
Lung cancer progression is characterized by intricate epigenetic changes that impact critical metabolic processes and cell death pathways. In this study, we investigate the role of histone lactylation at the AIM2 locus and its downstream effects on ...
Songze Wu, Man Liu, Xu Wang, Shan Wang
semanticscholar   +1 more source

AIM2 Suppresses Inflammation and Epithelial Cell Proliferation during Glomerulonephritis

The Journal of Immunology, 2021
Abstract Absent in melanoma-2 (AIM2) is an inflammasome-forming innate immune sensor for dsDNA but also exhibits inflammasome-independent functions such as restricting cellular proliferation. AIM2 is expressed in the kidney, but its localization and function are not fully characterized.
Hyunjae Chung, Takanori Komada, Arthur Lau, Mona Chappellaz, Jaye M Platnich, Heleen D de Koning, Björn Petri, Yosu Luque, Simon Walker, Hallgrimur Benediktsson, Laurent Mesnard, Justin Chun, Daniel A Muruve   +12 more
openaire   +2 more sources

Short-Chain Chlorinated Paraffins May Induce Ovarian Damage in Mice via AIM2- and NLRP12-PANoptosome.

Environmental Science and Technology
Humans may intake 0.02 mg/kg/day of short-chain chlorinated paraffins (SCCPs), and no study is available on mammalian ovarian damage caused by low-level SCCPs.
Mingxin Bai, Jiawei Lei, Fan Li, Xuning Wang, Hu Fu, Zhengli Yan, Yongfei Zhu   +6 more
semanticscholar   +1 more source

[DDX10 promotes AIM2-inflammasome activation by maintaining AIM2 protein stability].

Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 2020
Objective To investigating the role of DEAD box helicase 10 (DDX10) in regulating absent in melanoma 2 (AIM2)-inflammasome activity. Methods HEK293T-caspase-1-ASC-IL-1β (HEK293T-CIA) cells were transiently co-transfected with expression vector carrying AIM2 and one of the 10 candidate genes encoding DDX family members. To screen candidate regulators of
Shanmeizi, Zhao, Meng, Lin, Yuxia, Zhang
openaire   +1 more source

Reconstituted AIM2 inflammasome in cell-free system

Journal of Immunological Methods, 2015
Absent in melanoma 2 (AIM2) is an intracellular pattern-recognition receptor, which is a member of the PYHIN protein family, consisting of a PYD domain and an IFN-inducible nuclear localization (HIN) domain. AIM2 is reported to oligomerize with adaptor protein ASC upon sensing bacterial and viral cytosolic DNA in order to form the AIM2 inflammasome ...
Naoe, Kaneko, Yuki, Ito, Tomoyuki, Iwasaki, Hiroyuki, Takeda, Tatsuya, Sawasaki, Kiyoshi, Migita, Kazunaga, Agematsu, Atsushi, Kawakami, Shinnosuke, Morikawa, Sho, Mokuda, Mie, Kurata, Junya, Masumoto   +11 more
openaire   +2 more sources

AIM2 activation mediated by RIPK1/3-dependent mitochondrial DNA release drives Aβ1−40-Induced retinal pigment epithelium injury

Cell Communication and Signaling
The retinal pigment epithelium (RPE) degeneration and subsequent retinal atrophy are hallmarks of age-related macular degeneration (AMD). Amyloid-beta (Aβ), the primary component of amyloid plaques in Alzheimer’s disease (AD), is also present within ...
Xiaoxu Huang, Tong Li, Guanran Zhang, Jieqiong Chen, Tong Li, Shiqi Yang, Qiyu Bo, Xiaohuan Zhao, Xiaoling Wan, Xinyue Zhu, Bo Yu, Xiaodong Sun, Junran Sun   +12 more
semanticscholar   +1 more source

Chronic cerebral hypoperfusion activates AIM2 and NLRP3 inflammasome

Brain Research, 2020
Inflammation plays an important role in acute and chronic cerebral ischemia. Recent reports indicate that the inflammatory response triggered by tissue damage is mediated by a multiple-protein complex called the inflammasome. The NOD-like receptor family, pyrin domain containing 3 (NLRP3) and absent in melanoma 2 (AIM2) inflammasome complex triggers ...
Hirofumi Matsuyama, Akihiro Shindo, Takuya Shimada, Kenichiro Yata, Hideaki Wakita, Ryosuke Takahashi, Hidekazu Tomimoto   +6 more
openaire   +2 more sources

Astrocyte-derived CXCL10 exacerbates endothelial cells pyroptosis and blood–brain barrier disruption via CXCR3/cGAS/AIM2 pathway after intracerebral hemorrhage

Cell Death Discovery
Intracerebral hemorrhage (ICH) is a devastating disease that disrupts the blood–brain barrier (BBB), triggers inflammation, and leads to subsequent neurological deficits.
Wenqianjun Sheng, Zhangyi Wu, Jingyan Wei, Jun Wang, Shengfan Zhang, Zhiquan Ding, Jinhao Zhong, Dexian Deng, Z. Zhong, Yunong Yin, Yulong Li, Qinghua Wang   +11 more
semanticscholar   +1 more source

Autonomous intelligent modular surveillance system (AIM2S)

SPIE Proceedings, 2012
This paper discusses the design and development of an autonomous intelligent modular surveillance system (AIM2S). The system represents a novel class of "smart" surveillance platforms that integrates multiple sensors on an open-bus chassis. AIM2S modular architecture allows plug & play system operation, enabling its performance as a standalone unit ...
Vladimir Markov, Anatoliy Khizhnyak, Joseph Chavez, Stephen Kupiec, Daniel A. Erwin, Shiang Liu   +5 more
openaire   +1 more source

The Role of AIM2 in Cancer Development: Inflammasomes and Beyond

Journal of Cancer
Absence in melanoma 2 (AIM2) protein functions as a double-stranded DNA sensor and is critical for host defense against intracellular bacterial and viral pathogens.
Lina Sui, Yuling Xi, Siping Zheng, Qiuxiang Xiao, Zhiping Liu   +4 more
semanticscholar   +1 more source