Results 271 to 280 of about 22,661 (290)
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Inflammation
Human immunodeficiency virus (HIV)-infected individuals who abuse methamphetamine (METH) exhibit more severe neurotoxicity and cognitive impairment. Pyroptosis, a programmed cell death pathway mediated by the inflammasome, has been implicated in various ...
Lin Miao +9 more
semanticscholar +1 more source
Human immunodeficiency virus (HIV)-infected individuals who abuse methamphetamine (METH) exhibit more severe neurotoxicity and cognitive impairment. Pyroptosis, a programmed cell death pathway mediated by the inflammasome, has been implicated in various ...
Lin Miao +9 more
semanticscholar +1 more source
Mechanisms of AIM2 inflammasome regulation (P4093)
The Journal of Immunology, 2013Abstract Systemic lupus erythematosus (SLE) is an autoimmune syndrome typified by autoantibodies against DNA, chromatin, and RNA-associated proteins. Experimental evidence from our group and others suggests that RNA- and DNA-containing immune complexes isolated from SLE patients activates dendritic cells (DCs) through the nucleic acid ...
Amit Prasad +2 more
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Impact of AIM2 on HNSCC Development
AbstractHead and neck squamous cell carcinoma (HNSCC) constitutes 90% of head and neck cancers. HNSCC development is linked to chronic inflammation, while established HNSCC tumors are often immune suppressive. However, both occur through mechanisms that are not fully understood. The cytosolic double-stranded DNA sensor Absent in Melanoma 2 (AIM2) is anDakota M. Reinartz +4 more
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British Journal of Pharmacology
Cardio‐cerebrovascular diseases encompass pathological changes in the heart, brain and vascular system, which pose a great threat to health and well‐being worldwide.
Jiuguo Lin +7 more
semanticscholar +1 more source
Cardio‐cerebrovascular diseases encompass pathological changes in the heart, brain and vascular system, which pose a great threat to health and well‐being worldwide.
Jiuguo Lin +7 more
semanticscholar +1 more source
Obovatol inhibits NLRP3, AIM2, and non-canonical inflammasome activation
Phytomedicine, 2019Obovatol, a biphenolic chemical originating from Magnolia obovata, has been utilized as a traditional medicine for the treatment of inflammatory diseases. Inflammasome induces maturation of inflammatory cytokines in response to intracellular danger signals, and its dysregulation induces inflammatory diseases.The effect of obovatol on inflammasome ...
Jeongeun Kim +11 more
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Journal of Autoimmunity
Psoriasis vulgaris remains a common inflammatory skin disease globally. The imbalance between Th17 and Treg cells plays an integral role in the pathogenesis of psoriasis vulgaris, but the underlying mechanisms remain obscure. The role of AIM2 in Treg cell function in psoriasis is unclear. We found that AIM2 expression is upregulated in peripheral blood
Yue, Xin +11 more
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Psoriasis vulgaris remains a common inflammatory skin disease globally. The imbalance between Th17 and Treg cells plays an integral role in the pathogenesis of psoriasis vulgaris, but the underlying mechanisms remain obscure. The role of AIM2 in Treg cell function in psoriasis is unclear. We found that AIM2 expression is upregulated in peripheral blood
Yue, Xin +11 more
openaire +2 more sources
Integrated NLRP3, AIM2, NLRC4, Pyrin inflammasome activation and assembly drive PANoptosis
Cellular & Molecular Immunology, 2023SuHyeon Oh +6 more
semanticscholar +1 more source
Cross-talk between NLRP3 and AIM2 inflammasomes in macrophage activation by LPS and titanium ions
Molecular MedicineAna Belén Carrillo-Gálvez +9 more
semanticscholar +1 more source
Neutrophil extracellular traps promote acetaminophen-induced acute liver injury in mice via AIM2
Acta Pharmacologica SinicaFanle Zeng +10 more
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