Immunobiology and structural biology of AIM2 inflammasome
Molecular Aspects of Medicine, 2020 Absent in melanoma 2 (AIM2) is a cytoplasmic sensor that upon recognizing double-stranded DNA assembles with apoptosis-associated speck-like protein containing a CARD (ASC) and procaspase-1 to form the multi-protein complex AIM2 inflammasome. Double-stranded DNA from bacterial, viral, or host cellular origins triggers AIM2 inflammasome assembly and ...
Yuan Tian +4 more
openaire +3 more sources
Inflammasomes: caspase-1-activating platforms with critical roles in host defense [PDF]
, 2011 Activation of the inflammatory cysteine protease caspase-1 in inflammasome complexes plays a critical role in the host response to microbial infections.
Lieselotte eVande Walle +3 more
core +2 more sources
AIM2 in health and disease: Inflammasome and beyond
Immunological Reviews, 2020 AbstractNucleic acid sensing is a critical mechanism by which the immune system monitors for pathogen invasion. A set of germline‐encoded innate immune receptors detect microbial DNA in various compartments of the cell, such as endosomes, the cytosol, and the nucleus.
Puja Kumari +3 more
openaire +3 more sources
Expression of AIM2 in Rheumatoid Arthritis and Its Role on Fibroblast-Like Synoviocytes
Mediators of Inflammation, 2020 Objectives. To determine differences in AIM2 inflammasome expression levels between rheumatoid arthritis (RA) and osteoarthritis (OA) and to investigate the role of AIM2 in RA fibroblast-like synoviocytes (RA-FLS). Methods. Serum AIM2 levels among health
Yong Chen +7 more
doaj +1 more source
The mitochondrial protease HtrA2 restricts the NLRP3 and AIM2 inflammasomes. [PDF]
, 2018 Activation of the inflammasome pathway is crucial for effective intracellular host defense. The mitochondrial network plays an important role in inflammasome regulation but the mechanisms linking mitochondrial homeostasis to attenuation of inflammasome ...
Alnemri, Emad S. +9 more
core +3 more sources
Inflammasome as an Effective Platform for Fibrosis Therapy
Journal of Inflammation Research, 2021 Ting-Ting Chen,* Feng Xiao,* Nan Li, Shan Shan, Meng Qi, Zi-Ying Wang, Sheng-Nan Zhang, Wei Wei, Wu-Yi Sun Institute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Anhui
Chen TT +8 more
doaj
Absent in melanoma 2-mediating M1 macrophages facilitate tumor rejection in renal carcinoma
Translational Oncology, 2021 Absent in melanoma 2 (AIM2) as an immune regulator for the regulation of tumor-associated macrophages (TAMs) function is unclear in tumor development. Here, the AIM2 function was investigated in TAMs-mediated malignant behaviors of renal carcinoma.
Dafei Chai +10 more
doaj +1 more source
Vaccinia protein C16 blocks innate immune sensing of DNA by binding the Ku complex [PDF]
, 2011 VACV gene C16L encodes a 37-kDa protein that is highly conserved in orthopoxviruses and functions as an immunomodulator. Intranasal infection of mice with a virus lacking C16L (vΔC16) induced less weight loss, fewer signs of illness and increased ...
Peters, Nicholas Edward +1 more
core +1 more source
On damped Bernstein modes in a weakly relativistic pair plasma [PDF]
, 2005 Relativistic Bernstein modes are not totally undamped, but have a small, negative definite imaginary frequency component which peaks where the frequency is closest to the rest cyclotron ...
Diver, D.A., Laing, E.W.
core +1 more source
Multiorgan characterization of inflammasome component expression in a rat model of advanced heart failure. [PDF]
ESC Heart FailAbstract Aims Targeting inflammasomes in heart failure (HF) might represent a novel therapeutic option. Nevertheless, previous studies focused only on myocardial inflammasome alterations, and data are scarce regarding their regulation and role in HF‐associated multiorgan dysfunction.
Nagy D +12 more
europepmc +2 more sources