Results 41 to 50 of about 22,661 (290)
IKKα negatively regulates ASC-dependent inflammasome activation. [PDF]
, 2014 The inflammasomes are multiprotein complexes that activate caspase-1 in response to infections and stress, resulting in the secretion of pro-inflammatory cytokines.
Alnemri, Emad S +19 more
core +1 more source
AIM2 recognizes cytosolic dsDNA and forms a caspase-1 activating inflammasome with ASC
Nature, 2009 The innate immune system senses nucleic acids by germline-encoded pattern recognition receptors. RNA is sensed by Toll-like receptor members TLR3, TLR7 and TLR8, or by the RNA helicases RIG-I (also known as DDX58) and MDA-5 (IFIH1). Little is known about
V. Hornung +7 more
semanticscholar +1 more source
Inflammasomes: caspase-1-activating platforms with critical roles in host defense [PDF]
, 2011 Activation of the inflammatory cysteine protease caspase-1 in inflammasome complexes plays a critical role in the host response to microbial infections.
Lieselotte eVande Walle +3 more
core +2 more sources
AIM2 Joins the Gang of Microbial Sensors [PDF]
Cell Host & Microbe, 2010 AIM2 was recently implicated in the assembly and activation of the inflammasome in response to eukaryotic and viral dsDNA. Sauer and colleagues (2010) demonstrate that AIM2 is also involved in the activation of the inflammasome in response to the intracellular bacterium Listeria monocytogenes.
Franchi, Luigi, Nuñez, Gabriel
openaire +2 more sources
Frontiers in Cell and Developmental Biology, 2021 Intervertebral disc degeneration (IDD) is the primary cause of low back pain. Stress-induced DNA damage is closely relevant to the pathogenesis of IDD; however, the underlying mechanisms remain unclear.
Shuai Li +11 more
doaj +1 more source
The mitochondrial protease HtrA2 restricts the NLRP3 and AIM2 inflammasomes. [PDF]
, 2018 Activation of the inflammasome pathway is crucial for effective intracellular host defense. The mitochondrial network plays an important role in inflammasome regulation but the mechanisms linking mitochondrial homeostasis to attenuation of inflammasome ...
Alnemri, Emad S. +9 more
core +4 more sources
Immunobiology and structural biology of AIM2 inflammasome
Molecular Aspects of Medicine, 2020 Absent in melanoma 2 (AIM2) is a cytoplasmic sensor that upon recognizing double-stranded DNA assembles with apoptosis-associated speck-like protein containing a CARD (ASC) and procaspase-1 to form the multi-protein complex AIM2 inflammasome. Double-stranded DNA from bacterial, viral, or host cellular origins triggers AIM2 inflammasome assembly and ...
Bing, Wang +4 more
openaire +3 more sources
The Role of AIM2 Inflammasome in Knee Osteoarthritis
Journal of Inflammation Research, 2022 Knee osteoarthritis (KOA), whose prevalence keeps rising, is still unsolved pathobiological/therapeutical problem. Historically, knee osteoarthritis was thought to be a "wear and tear" disease, while recent etiology hypotheses stressed it as a chronic, low-grade inflammatory disease.
Jiyong Yang, Wengang Liu
openaire +4 more sources
Inflammasome as an Effective Platform for Fibrosis Therapy
Journal of Inflammation Research, 2021 Ting-Ting Chen,* Feng Xiao,* Nan Li, Shan Shan, Meng Qi, Zi-Ying Wang, Sheng-Nan Zhang, Wei Wei, Wu-Yi Sun Institute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Anhui
Chen TT +8 more
doaj
On damped Bernstein modes in a weakly relativistic pair plasma [PDF]
, 2005 Relativistic Bernstein modes are not totally undamped, but have a small, negative definite imaginary frequency component which peaks where the frequency is closest to the rest cyclotron ...
Diver, D.A., Laing, E.W.
core +1 more source