Results 211 to 220 of about 67,377 (251)

The airway epithelium in asthma

2019
Asthma is a genetically and phenotypically complex disease that has a major impact on global health. Signs and symptoms of asthma are caused by the obstruction of airflow through the airways. The epithelium that lines the airways plays a major role in maintaining airway patency and in host defense.
Luke R, Bonser, David J, Erle
openaire   +2 more sources

The airway epithelium in childhood asthma

Journal of Allergy and Clinical Immunology, 2012
There has been a focus for more than 40 years on the bronchial epithelium as an important structure in initiating the physiologic and clinical abnormalities of asthma. This makes sense because the bronchial epithelium is the initial barrier met by all inhaled irritants, toxins, or allergens, and the bronchial epithelium’s response to these noxious ...
O'Byrne, Paul M, Pedersen, Søren
openaire   +2 more sources

Barrier function of airway tract epithelium [PDF]

Tissue Barriers, 2013
Airway epithelium contributes significantly to the barrier function of airway tract. Mucociliary escalator, intercellular apical junctional complexes which regulate paracellular permeability and antimicrobial peptides secreted by the airway epithelial cells are the three primary components of barrier function of airway tract. These three components act
Shyamala Ganesan, Adam T Comstock, Uma S Sajjan   +2 more
exaly   +3 more sources

Cystic fibrosis airway epithelium remodelling: involvement of inflammation

Journal of Pathology, 2015
International audienceChronic inflammation is a hallmark of cystic fibrosis (CF) lung disease and airway epithelium damage and remodelling are important components of lung pathology progression in CF.
Damien Adam, Arnaud Bonnomet, Jean-Claude Merol   +2 more
exaly   +2 more sources

Airway epithelium and apoptosis

Apoptosis, 1999
Recent advances revealed that airway epithelium possesses versatile functions and plays a vital role in the mucosal defense and inflammatory responses. A maintenance of airway epithelium integrity is thus important and appears to be tightly regulated by a balanced cell proliferation and apoptosis.
openaire   +2 more sources

Cell Jamming in the Airway Epithelium

Annals of the American Thoracic Society, 2016
Abstract Hallmarks of asthma include chronic airway inflammation, progressive airway remodeling, and airway hyperresponsiveness. The initiation and perpetuation of these processes are attributable at least in part to critical events within the airway epithelium, but the underlying mechanisms remain poorly understood.
Jin-Ah, Park, Jeffrey J, Fredberg
openaire   +2 more sources

Remodeling of the Airway Epithelium in Asthma

American Journal of Respiratory and Critical Care Medicine, 2001
Abstract Several pathologic changes occur in the airway epithelium in asthma, but the relationship between these changes and the initiation and progression of asthma remains poorly understood. One possibility is that changes in the structure and function of the epithelium induced by environmental exposure in genetically susceptible ...
openaire   +2 more sources

Neoplastic Development in Airway Epithelium

1983
Publisher Summary Bronchogenic carcinoma is the most common fatal neoplastic disease in many parts of the world. The etiology of bronchogenic carcinoma is more firmly established than that of most other cancers. The evidence is overwhelming that most lung cancers are caused by tobacco smoke inhalation, the incidence depending on the duration of ...
P, Nettesheim, A, Marchok
openaire   +2 more sources

Airway epithelium and bronchial reactivity

Canadian Journal of Physiology and Pharmacology, 1987
Damage to or dysfunction of respiratory epithelial cells may contribute to the etiology of bronchial hyperreactivity in asthma and airway infection. In the vascular system, endogenous neurohumoral mediators can cause either relaxation or contraction of the smooth muscle of the blood vessel wall because they cause the release of relaxing or contracting
openaire   +4 more sources

Airway epithelium-derived inhibitory factor

Trends in Pharmacological Sciences, 1990
Various bronchoactive agents can induce the release from the airway epithelium of an inhibitory substance that is able to relax certain tissues including rat aorta and possibly also airway smooth muscle. This substance, whose existence has recently been confirmed using a new bioassay system, is distinct from nitric oxide (EDRF) and is also known to be ...
R G, Goldie, L B, Fernandes, S G, Farmer, D W, Hay   +3 more
openaire   +2 more sources