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The airway epithelium in asthma
2019Asthma is a genetically and phenotypically complex disease that has a major impact on global health. Signs and symptoms of asthma are caused by the obstruction of airflow through the airways. The epithelium that lines the airways plays a major role in maintaining airway patency and in host defense.
Luke R, Bonser, David J, Erle
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The airway epithelium in childhood asthma
Journal of Allergy and Clinical Immunology, 2012There has been a focus for more than 40 years on the bronchial epithelium as an important structure in initiating the physiologic and clinical abnormalities of asthma. This makes sense because the bronchial epithelium is the initial barrier met by all inhaled irritants, toxins, or allergens, and the bronchial epithelium’s response to these noxious ...
O'Byrne, Paul M, Pedersen, Søren
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Airway epithelium and apoptosis
Apoptosis, 1999Recent advances revealed that airway epithelium possesses versatile functions and plays a vital role in the mucosal defense and inflammatory responses. A maintenance of airway epithelium integrity is thus important and appears to be tightly regulated by a balanced cell proliferation and apoptosis.
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Cell Jamming in the Airway Epithelium
Annals of the American Thoracic Society, 2016Abstract Hallmarks of asthma include chronic airway inflammation, progressive airway remodeling, and airway hyperresponsiveness. The initiation and perpetuation of these processes are attributable at least in part to critical events within the airway epithelium, but the underlying mechanisms remain poorly understood.
Jin-Ah, Park, Jeffrey J, Fredberg
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Remodeling of the Airway Epithelium in Asthma
American Journal of Respiratory and Critical Care Medicine, 2001Abstract Several pathologic changes occur in the airway epithelium in asthma, but the relationship between these changes and the initiation and progression of asthma remains poorly understood. One possibility is that changes in the structure and function of the epithelium induced by environmental exposure in genetically susceptible ...
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Neoplastic Development in Airway Epithelium
1983Publisher Summary Bronchogenic carcinoma is the most common fatal neoplastic disease in many parts of the world. The etiology of bronchogenic carcinoma is more firmly established than that of most other cancers. The evidence is overwhelming that most lung cancers are caused by tobacco smoke inhalation, the incidence depending on the duration of ...
P, Nettesheim, A, Marchok
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Airway epithelium and bronchial reactivity
Canadian Journal of Physiology and Pharmacology, 1987Damage to or dysfunction of respiratory epithelial cells may contribute to the etiology of bronchial hyperreactivity in asthma and airway infection. In the vascular system, endogenous neurohumoral mediators can cause either relaxation or contraction of the smooth muscle of the blood vessel wall because they cause the release of relaxing or contracting
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1992
Ciliated cells and goblet cells are the cells most exposed to external noxae, and thus more subject to damage. In chronic bronchitic disease and in other pulmonary diseases in which there is abnormal mucus production, the goblet cells appear swollen and increased in number, while cilia are often nonuniformly glued to each other by mucus.
P. C. Braga, L. Allegra, G. Piatti
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Ciliated cells and goblet cells are the cells most exposed to external noxae, and thus more subject to damage. In chronic bronchitic disease and in other pulmonary diseases in which there is abnormal mucus production, the goblet cells appear swollen and increased in number, while cilia are often nonuniformly glued to each other by mucus.
P. C. Braga, L. Allegra, G. Piatti
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Airway epithelium-derived inhibitory factor
Trends in Pharmacological Sciences, 1990Various bronchoactive agents can induce the release from the airway epithelium of an inhibitory substance that is able to relax certain tissues including rat aorta and possibly also airway smooth muscle. This substance, whose existence has recently been confirmed using a new bioassay system, is distinct from nitric oxide (EDRF) and is also known to be ...
R G, Goldie +3 more
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Endothelin and the Airway Epithelium
1999The airway epithelium plays an important role in host defense as a barrier against physical, pathological and chemical stimuli. The epithelium is also an active metabolic and biosynthetic site for production and release of mediators, such as arachidonic acid metabolites, cytokines and a putative epithelium-derived refaxing factor, associated with the ...
Joaquim Mullol +3 more
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