Results 61 to 70 of about 375,726 (199)

Airway epithelium and asthma:Virus exposure, airway inflammation and metabolism [PDF]

, 2020
Asthma is a respiratory chronic inflammatory disease with well-established symptoms, but the pathophysiological mechanisms remain largely unexplored. In this thesis, we aim to analyse and clarify responses of asthmatic airway epithelial cells.In chapter ...
Ravi, A.
core   +4 more sources

Airway Epithelium Dysfunction in Cystic Fibrosis and COPD

Mediators of Inflammation, 2018
Cystic fibrosis is a genetic disease caused by mutations in the CFTR gene, whereas chronic obstructive pulmonary disease (COPD) is mainly caused by environmental factors (mostly cigarette smoking) on a genetically susceptible background.
Virginia De Rose, Kevin Molloy, Sophie Gohy, Charles Pilette, Catherine M. Greene   +4 more
doaj   +1 more source

Rare SOX2+ Airway Progenitor Cells Generate KRT5+ Cells that Repopulate Damaged Alveolar Parenchyma following Influenza Virus Infection

Stem Cell Reports, 2016
Recent studies have implicated keratin 5 (KRT5)+ cells in repopulation of damaged lung tissue following severe H1N1 influenza virus infection. However, the origins of the cells repopulating the injured alveolar region remain controversial.
Samriddha Ray, Norika Chiba, Changfu Yao, Xiangrong Guan, Alicia M. McConnell, Brian Brockway, Loretta Que, Jonathan L. McQualter, Barry R. Stripp   +8 more
doaj   +1 more source

A new look at the pathogenesis of asthma

, 2009
Asthma is an inflammatory disorder of the conducting airways that has strong association with allergic sensitization. The disease is characterized by a polarized Th-2 (T-helper-2)-type T-cell response, but in general targeting this component of the ...
Graham C. Roberts, Philipp Thurner, Stephen T. Holgate, Donna E. Davies, Arshad, Hasan S., Howarth, Peter H., Davies, Donna E., Holgate, Stephen T., Roberts, Graham C., Thurner, Philipp J., Hasan S. Arshad, Peter H. Howarth   +11 more
core   +1 more source

Endowing Flexibility of Alveolar Type II Cells to Recapitulate Development From Lung Bud to Alveoli

Advanced Science, EarlyView.
Adult human alveolar type 2 cells are chemically reprogrammed into expandable alveolar progenitor‐like cells that acquire bud tip‐like features during expansion and form organoids that mature into alveolar‐like structures. These organoids model influenza A virus infection and innate immune responses in vitro, while transplanted cells engraft ...
Hongqian Ma, Yuxin Zhang, Lujia Sun, Hong Jiang, Fan Li, Wenming Liu, Shenao Zhou, Mengting Wang, Weijian Huang, Xu Zhou, Caiyang Chen, Qiuqiu Zhang, Xiaoyan Jin, Feihan Yan, Hongping Wu, Yonghong Yin, Xinling Wang, Hexin Yan, Weifeng Yu   +18 more
wiley   +1 more source

Cx43 levels guide apicobasal polarity in regenerating airway epithelial cells

Communications Biology
Apicobasal polarity plays key roles in airway epithelial maturation and regeneration. Once polarized, the airway epithelium functions as a barrier against opportunistic pathogens. Yet, the mechanisms that temporally regulate polarization, a process which
Mehdi Badaoui, Alexandre Luscher, Mengjie Ma, Marc Bacchetta, Christian van Delden, Thilo Köhler, Arantxa Tabernero, Marc Chanson   +7 more
doaj   +1 more source

Microarray analysis identifies defects in regenerative and immune response pathways in COPD airway basal cells

ERJ Open Research, 2020
Background Airway basal cells are specialised stem cells and regenerate airway epithelium. Airway basal cells isolated from patients with COPD regenerate airway epithelium with an abnormal phenotype. We performed gene expression analysis to gain insights
Fanny Pineau, Gabriella Shumyatsky, Nicole Owuor, Nisha Nalamala, Sudhir Kotnala, Sudhir Bolla, Nathaniel Marchetti, Steven Kelsen, Gerard J. Criner, Uma S. Sajjan   +9 more
doaj   +1 more source

Hypoxia-Inducible Factor-1α Regulates CD55 in Airway Epithelium [PDF]

, 2016
Airway epithelial CD55 down-regulation occurs in several hypoxia-associated pulmonary diseases, but the mechanism is unknown. Using in vivo and in vitro assays of pharmacologic inhibition and gene silencing, the current study investigated the role of ...
Gracon, Adam, Sandusky, George E., Pollok, Karen, Renbarger, Jamie, Pandya, Pankita H., Blum, Janice S., Murray, Mary, Lahm, Tim, Fisher, Amanda J., Temm, Constance J., Rothhaar, Katia, Lipking, Kelsey P., Mickler, Elizabeth A., Wilkes, David S.   +13 more
core   +1 more source

Developing Highly Effective Nanoparticle mRNA Therapeutic for Pediatric Acute Respiratory Distress Syndrome

Advanced Science, EarlyView.
Sepsis‑induced pediatric acute respiratory distress syndrome suppresses FOXF1 in lung endothelial cells which causes life‐threatening lung damage. To counter this, researchers developed nanoparticles that specifically target these cells and deliver FOXF1 mRNA.
Zicheng Deng, Wen Gao, Jonathan Do, Danli Lu, Ying‐Wei Lan, Andreas Damianos, Gautam Verma, Ali Al Siraj, Isabella Lowry, Lance Peter, Nicholas E. Banovich, Fei Sun, Hua He, Tanya V. Kalin, Vladimir V. Kalinichenko   +14 more
wiley   +1 more source

NS1‐Induced PARP1 Phase Transitions Prolongs Host Transcriptional Pausing to Promote Influenza A Virus Replication

Advanced Science, EarlyView.
After IAV infection, NS1 induces PARP1 phase transition, reducing molecular mobility in condensates, prolonging host transcriptional pause, aiding RdRp cap snatching, and promoting viral transcription. ABSTRACT Influenza A virus (IAV) commandeers host transcriptional machinery to replicate, but mechanisms remain elusive.
Shufeng Ma, Changyuan Kang, Xixian Liu, Lichao Yang, Mengyi Li, Yuting Ye, Jianfang Zhang, Yingjun Li, Guanghui Jin, Yang Liu, Xiaohong Chen, Kexin Wang, Zifeng Yang   +12 more
wiley   +1 more source