Results 91 to 100 of about 1,027,405 (258)

Microfluidic Gratings for X‐Ray Phase Contrast Imaging

Advanced Science, EarlyView.
This work establishes a new protocol for the fabrication of X‐ray gratings that exploits the advantages of microfluidics and enables a more inexpensive, faster, and scalable production process. These X‐ray devices are fundamental for implementing X‐ray phase contrast imaging (XPCI) in laboratory and clinical settings, yet their costly and complex ...
Alessandro Rossi, Antonio Ferraro, Francesco Coccimiglio, Tiziana Ritacco, Alberto Astolfo, Michele Giocondo, Vincenzo Formoso, Raffaele Giuseppe Agostino, Francesco Iacoviello, Ioannis Papakonstantinou, Alessandro Olivo   +10 more
wiley   +1 more source

Regulation of Interaction Between the Upper and Lower Airways in United Airway Disease

Medical Sciences, 2019
The concept of united airway disease comprises allergic rhinitis (AR) with asthma, and eosinophilic chronic rhinosinusitis (ECRS) with asthma. It embodies a comprehensive approach to the treatment of upper and lower airway inflammation.
Akira Kanda, Yoshiki Kobayashi, Mikiya Asako, Koichi Tomoda, Hideyuki Kawauchi, Hiroshi Iwai   +5 more
doaj   +1 more source

Bone Marrow Macrophage STING Signaling is a Direct Nexus Linking Marrow Adipose Expansion to NAD+ Depletion and Osteogenic Decline in Skeletal Aging

Advanced Science, EarlyView.
This study reveals that during skeletal aging, bone marrow adipocyte‐derived sDPP4 primes STING signaling in macrophages. In combination with mitochondrial DNA, this signaling activates CD38 and depletes local NAD+/NMN, thereby impairing osteogenesis.
Zhichao Li, Kuanhui Gao, Mengjie Wang, Songlin Liang, Dandan Li, Guoqing Tan, Haipeng Xue, Yujie Liu, Peng Zhang, Zhanwang Xu, Wenxiang Cheng, Yongjun Wang, Nianhu Li   +12 more
wiley   +1 more source

EGF-induced bronchial epithelial cells drive neutrophil chemotactic and anti-apoptotic activity in asthma [PDF]

, 2013
Chronic damage and repair of the bronchial epithelium are features of asthma. We have previously reported that ex vivo stimulation of normal bronchial epithelial cells with epidermal growth factor (EGF), a key factor of epithelial repair, enhances the ...
Donna E Davies, Cornelius Victoria, Grégory Seumois, Lau, LC, Karl J Staples, Cornelius, Victoria, Dorinsky, P, Victoria Cornelius, Davies Donna E., Dinesh Bagmane (457229), Staples, Karl J., Uddin, Mohib, Ratko Djukanović, Pandurangan Vijayanand, Victoria Cornelius (457230), Lau, Laurie C., Mohib Uddin (457226), Karl J. Staples (457228), Bagmane, Dinesh, Ratko Djukanović (457232), Paul Dorinsky, Pandurangan Vijayanand (277869), Djukanović Ratko, Lau, Laurie C, Grégory Seumois (5656213), Lau Laurie C., Staples, KJ, Vijayanand, P, Vijayanand, Pandurangan, Laurie C. Lau (457227), Seumois, G, Uddin, M, Staples, Karl J, Davies, Donna E, Staples Karl J., Davies, DE, Donna E. Davies (137702), Seumois Grégory, Djukanović, R, Dinesh Bagmane, Djukanović, Ratko, Cornelius, V, Davies, Donna E., Laurie C Lau, Dorinsky Paul, Paul Dorinsky (457231), Dorinsky, Paul, Seumois, Grégory, Bagmane Dinesh, Uddin Mohib, Bagmane, D, Mohib Uddin, Vijayanand Pandurangan   +52 more
core   +2 more sources

Mapping Embryonic Mouse Lung Development Using Enhanced Spatial Transcriptomics

Advanced Science, EarlyView.
The mammalian lung contains ∼50 cell types arranged along the airway epithelium. Here, deterministic barcoding sequencing (DBiT‐seq) is optimized to nearly double transcript recovery, enabling highly sensitive spatial mapping of the embryonic mouse lung.
Pengfei Zhang, Benjamin K. Law, Niles Huang, Katharine Goodwin, Celeste M. Nelson, Michelle M. Chan   +5 more
wiley   +1 more source

Alpha7 nicotinic acetylcholine receptor activation attenuates allergic airway inflammation and is associated with heme oxygenase-1 induction

Frontiers in Immunology
BackgroundActivation of the α7 nicotinic acetylcholine receptor (α7nAChR) exerts anti-inflammatory effects; however, its role in allergic airway inflammation remains poorly understood. This study investigated how GTS-21 treatment, consistent with α7nAChR
Jun Iriki, Jun Iriki, Susumu Fukahori, Yasushi Obase, Yasushi Obase, Yasuna Nakamura, Ryusuke Umene, Ryusuke Umene, Chia-Hsien Wu, Yuri Yamada, Yuri Yamada, Shinnosuke Takemoto, Takahiro Takazono, Takahiro Takazono, Noriho Sakamoto, Chizu Fukushima, Chizu Fukushima, Tomoya Nishino, Hiroshi Mukae, Hiroshi Mukae, Tsuyoshi Inoue   +20 more
doaj   +1 more source

A General High‐Throughput Mucus Microrheology Platform for Quantitative and Scalable Mucus Phenotyping

Advanced Science, EarlyView.
High‐throughput Differential Dynamic Microscopy measures frequency‐resolved mechanical fingerprints from 3 to 10 μL$\umu{\rm L}$ mucus samples using only a few minutes of operator attention per sample. This automated analysis enables scalable mucus phenotyping for translational research by distinguishing mechanical heterogeneity among donors, disease ...
Feng Ling, Ayşe Tuğçe Şahin, Bernardo Miller Naranjo, Stefano Aime, Doris Roth, Anna Pukaluk, Niels Tepho, Romina Augustin, Benedetta Zampa, Andrea S. Vendrame, Mark‐Christian Klassen, Ellen Emken, Marion Kiechle, Mircea Gabriel Stoleriu, Pontus Mertsch, Ruth Olmer, Yohannes Tesfaigzi, Oliver Lieleg, Janna C. Nawroth   +18 more
wiley   +1 more source

Relationship between airway pathophysiology and airway inflammation in older asthmatics

, 2013
Background and objectiveAsthma-related morbidity is greater in older compared with younger asthmatics. Airway closure is also greater in older asthmatics, an observation that may be explained by differences in airway inflammation. We hypothesized that in
Pretto, Jeffrey J., Salome, Cheryl M, Gibson, Peter G, King, Gregory G, Porsbjerg, Celeste M., Porsbjerg, Celeste M, Pretto, Jeffrey J, Brown, Nathan J., Salome, Cheryl M., Brown, Nathan J, Berend, Norbert, Gibson, Peter G., King, Gregory G.   +12 more
core   +1 more source

Endowing Flexibility of Alveolar Type II Cells to Recapitulate Development From Lung Bud to Alveoli

Advanced Science, EarlyView.
Adult human alveolar type 2 cells are chemically reprogrammed into expandable alveolar progenitor‐like cells that acquire bud tip‐like features during expansion and form organoids that mature into alveolar‐like structures. These organoids model influenza A virus infection and innate immune responses in vitro, while transplanted cells engraft ...
Hongqian Ma, Yuxin Zhang, Lujia Sun, Hong Jiang, Fan Li, Wenming Liu, Shenao Zhou, Mengting Wang, Weijian Huang, Xu Zhou, Caiyang Chen, Qiuqiu Zhang, Xiaoyan Jin, Feihan Yan, Hongping Wu, Yonghong Yin, Xinling Wang, Hexin Yan, Weifeng Yu   +18 more
wiley   +1 more source

Human iPSC-MSCs prevent steroid-resistant neutrophilic airway inflammation via modulating Th17 phenotypes

Stem Cell Research & Therapy, 2018
Background Human induced pluripotent stem cells-derived mesenchymal stem cells (iPSC-MSCs) have been shown to be effective in Type 2 helper T cells (Th2)-dominant eosinophilic allergic airway inflammation. However, the role of iPSC-MSCs in Type 17 helper
Shu-Bin Fang, Hong-Yu Zhang, Ai-Yun Jiang, Xing-Liang Fan, Yong-Dong Lin, Cheng-Lin Li, Cong Wang, Xiang-Ci Meng, Qing-Ling Fu   +8 more
doaj   +1 more source