Results 101 to 110 of about 1,027,405 (258)

Developing Highly Effective Nanoparticle mRNA Therapeutic for Pediatric Acute Respiratory Distress Syndrome

Advanced Science, EarlyView.
Sepsis‑induced pediatric acute respiratory distress syndrome suppresses FOXF1 in lung endothelial cells which causes life‐threatening lung damage. To counter this, researchers developed nanoparticles that specifically target these cells and deliver FOXF1 mRNA.
Zicheng Deng, Wen Gao, Jonathan Do, Danli Lu, Ying‐Wei Lan, Andreas Damianos, Gautam Verma, Ali Al Siraj, Isabella Lowry, Lance Peter, Nicholas E. Banovich, Fei Sun, Hua He, Tanya V. Kalin, Vladimir V. Kalinichenko   +14 more
wiley   +1 more source

Late airway obstruction and neutrophil infiltration in sensitized mice after antigen provocation were suppressed by selective and non-selective phosphodiesterase inhibitors

Allergology International, 1997
Suppression of antigen-induced late airway obstruction associated with neutrophilic inflammation by selective and non-selective phosphodiesterase (PDE) inhibitors was investigated in mice.
Osamu Kaminuma, Shinya Murakami, Matsunobu Suko, Hideo Kikkawa, Shigeki Matsubara, Wataru Toriumi, Katsuo Ikezawa, Hirokazu Okudaira, Koji Ito   +8 more
doaj   +1 more source

Smartphone‐Guided Visible Light Modulation of RSNOs for Antimicrobial Activity via Controlled Nitric Oxide Release

Advanced Science, EarlyView.
A light‐activated catheter insert combines antimicrobial blue light with nitric oxide release to generate complementary oxidative and nitrosative stress, producing potent broad‐spectrum antimicrobial activity. The approach achieves greater than 4‐log reductions in bacterial and fungal viability and significantly reduces Staphylococcus aureus ...
Alexander Bruckmann, Adam Brooks Goodman, Myddelton C. Parker, Mark Garren, Ji Eun Park, Chad Schmiedt, Hitesh Handa, Elizabeth J. Brisbois   +7 more
wiley   +1 more source

Airway cell involvement in intermittent hypoxia-induced airway inflammation

, 2015
International audienceRespiratory inflammation has been described in patients with obstructive sleep apnea syndrome, but it is unknown whether the increased neutrophil and interleukin (IL)-8 levels observed in induced sputum reflect systemic or local ...
D’Ortho, M, P, Clérici, C., Boussadia, Y., Isabey, D., V. Prulière-Escabasse, D. Isabey, Escudier, E., A. Coste, Y. Boussadia, M P. d’Ortho, Philippe, C., J F. Papon, C. Clérici, Coste, A., E. Escudier, Prulière-Escabasse, V., Papon, J, F, C. Philippe   +17 more
core   +1 more source

NS1‐Induced PARP1 Phase Transitions Prolongs Host Transcriptional Pausing to Promote Influenza A Virus Replication

Advanced Science, EarlyView.
After IAV infection, NS1 induces PARP1 phase transition, reducing molecular mobility in condensates, prolonging host transcriptional pause, aiding RdRp cap snatching, and promoting viral transcription. ABSTRACT Influenza A virus (IAV) commandeers host transcriptional machinery to replicate, but mechanisms remain elusive.
Shufeng Ma, Changyuan Kang, Xixian Liu, Lichao Yang, Mengyi Li, Yuting Ye, Jianfang Zhang, Yingjun Li, Guanghui Jin, Yang Liu, Xiaohong Chen, Kexin Wang, Zifeng Yang   +12 more
wiley   +1 more source

A Robust Bio‐Supportive Hydrogel Patch for Full‐Thickness Repair of Gastroesophageal Defects

Advanced Science, EarlyView.
Gastroesophageal defect repair remains a formidable clinical challenge plagued by high leakage and life‐threatening complications. We develop a double‐disc, highly crystalline PVA‐based RBS hydrogel patch featuring suture‐free sealing, robust acid/enzyme resistance and mechanical durability.
Xingqi Song, Zhewei Shuai, Weiyan Sun, Liang Chen, Yiwei Shen, Jiateng Hu, Yuanqi Ma, Jie Luo, Meilin Huang, Yan Luo, Yunlang She, Guangdong Zhou, Chang Chen, Dong Lei   +13 more
wiley   +1 more source

Effect of levofloxacin on neutrophilic airway inflammation in stable COPD: a randomized, double-blind, placebo-controlled trial

, 2014
Roshan Siva,1 Mona Bafadhel,2 William Monteiro,3 Christopher E Brightling,3 Ian D Pavord2 1Department of Respiratory Medicine, Croydon University Hospital, Croydon Health Services NHS Trust, London, 2Department of Respiratory Medicine, Nuffield ...
Siva R, Bafadhel M, Monteiro W, Pavord ID, Brightling CE   +4 more
core  

Curvature‐Directed Elongation and Chiral Tilting Drive Asymmetric Tissue Patterning

Advanced Science, EarlyView.
Curvature and cell handedness together break tissue symmetry. On convex and concave surfaces, cells elongate along opposite geometric axes and tilt in a consistent chirality‐driven direction, yielding opposite alignment patterns from the same cells. Reversing intrinsic cell chirality reverses both.
Liyao Xu, Frank Daniel Peters, Haokang Zhang, Madison Stiefbold, Thangam Ramar, Aditya Agarwal, Leo Q. Wan   +6 more
wiley   +1 more source

Lung sound analysis helps localize airway inflammation in patients with bronchial asthma

, 2017
Terufumi Shimoda,1 Yasushi Obase,2 Yukio Nagasaka,3 Hiroshi Nakano,1 Akiko Ishimatsu,1 Reiko Kishikawa,1 Tomoaki Iwanaga1 1Clinical Research Center, Fukuoka National Hospital, Fukuoka, 2Second Department of Internal Medicine, School of Medicine, Nagasaki
Nagasaka Y, Kishikawa R, Shimoda T, Obase Y, Nakano H, Ishimatsu A, Iwanaga T   +6 more
core  

ACAT1‐Mediated SP1‐K694 Lactylation Promotes M1 Macrophage Polarization via TREM1 Transcription in COPD

Advanced Science, EarlyView.
Upon cigarette smoke exposure(CSE), LDHA expression is increased in lung macrophages, promoting the conversion of pyruvate to lactate and elevating the lactylation level of SP1 at the K694 site. This, in turn, enhances SP1 enrichment at the TREM1 promoter, increases TREM1 expression, promoted M1 macrophage polarization, and triggers the secretion of ...
Ling Lin, Ping Zhang, Qing Song, Tao Li, Yuqin Zeng, Ping Chen   +5 more
wiley   +1 more source