Results 121 to 130 of about 1,027,405 (258)

Tezepelumab in Chinese Patients With Severe Chronic Rhinosinusitis With Nasal Polyps: A Prespecified Subgroup Analysis of the Phase 3 WAYPOINT Trial

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis with nasal polyps (CRSwNP) in Chinese patients often exhibits a mixed Type 1/2/3 inflammatory phenotype (63%), potentially impacting the efficacy of biologics targeting Type 2 inflammation. This prespecified subgroup analysis of WAYPOINT (NCT04851964) evaluated the efficacy and safety of tezepelumab in Chinese
Li Hu, Houyong Li, Xicai Sun, Quan Liu, Yu Xu, Jiangang Fan, Andrew Foster, Claudia Chen, Yun Chon, Dehui Wang   +9 more
wiley   +1 more source

Role of inflammatory cells in airway remodeling in COPD

International Journal of COPD, 2018
Yujie Wang,1,2 Jiayan Xu,1 Yaqi Meng,1 Ian M Adcock,3 Xin Yao1 1Department of Respiratory Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China; 2Department of Respiratory Medicine, The Second Affiliated Hospital of ...
Wang Y, Xu J, Meng Y, Adcock IM, Yao X
doaj  

SERPINB10 promotes macrophage M2 polarization and airway inflammation in asthma

Respiratory Research
Background Macrophage M2 polarization plays a critical role in type 2 airway inflammation in asthma. We previously reported that serine peptidase inhibitor, clade B, member 10 (SERPINB10) promotes airway eosinophilic inflammation in asthma.
Lu Zhao, Wenliang Wu, Gongqi Chen, Chunli Huang, Weiqiang Kong, Wei Gu, Huiru Jie, Lingling Yi, Guohua Zhen   +8 more
doaj   +1 more source

Characterization on the airway inflammation on the study population.

, 2018
Characterization on the airway inflammation on the study population.
Catherine Lemiere (4907335), Jad Hobeika (4907338), Iñigo Ojanguren (2825615), Marc Miravitlles (528052), Gregory Moullec (2733328)   +4 more
core   +1 more source

Inflammatory Signatures Beyond Th1/Th2 Endotypes Provide Insights Into Postoperative Recurrence in Chronic Rhinosinusitis

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis (CRS) represents a spectrum of inflammatory endotypes, driven by distinct T helper (Th) immune responses. The high rate of recurrent disease despite appropriate medical and surgical interventions highlights the need for improved characterization beyond the traditional type 2 and non‐type 2 phenotypes to better
Liyona Kampel, Narin N. Carmel, Shaun Edalati, Hen Chaushu, Forsan Jahshan, Yaniv Hadi, Timur Pestrikov, Leonor Leider Trejo, Nidal Muhanna, Avraham Abergel   +9 more
wiley   +1 more source

Lung Sound Analysis Provides A Useful Index For Both Airway Narrowing And Airway Inflammation In Patients With Bronchial Asthma

Journal of Asthma and Allergy, 2019
Terufumi Shimoda,1,2 Yasushi Obase,3 Yukio Nagasaka,4 Reiko Kishikawa,2 Sadahiro Asai1 1Department of Allergy, San Remo Rehabilitation Hospital, Sasebo, Japan; 2Department of Allergy, Clinical Research Center, Fukuoka National Hospital, Fukuoka, Japan ...
Shimoda T, Obase Y, Nagasaka Y, Kishikawa R, Asai S   +4 more
doaj  

Airway remodelling and inflammation features in bronchial biopsies.

, 2016
Airway remodelling and inflammation features in bronchial biopsies.
Camille Taillé (829699), Anny Rouvel-Tallec (2548666), Claire Danel (187897), Marie-Pia d’Ortho (2548654), Maria Stoica (2548660), Monique Dehoux (288324), Marina Pretolani (2548651), Viviana Marin-Esteban (2548663), Michel Aubier (2548657)   +8 more
core   +1 more source

Clinical Longitudinal Evaluation After Regimen Stop (CLEAR) of Dupilumab in Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Long‐term management strategies for severe chronic rhinosinusitis with nasal polyps (CRSwNP) increasingly include biologic therapy targeting Type 2 inflammation. However, data on outcomes after complete discontinuation of dupilumab following sustained disease control are scarce.
Patrick Huber, Manuel Lasch, Veronika Volgger, Clemens Stihl, Philipp Teupe, Fabienne Oettgen, Sophia Gantner, Moritz Gröger   +7 more
wiley   +1 more source

The Mechanisms and Therapeutic Implications of PI3K Signaling in Airway Inflammation and Remodeling in Asthma

Biologics: Targets & Therapy
Bangguo Song,1 Jihong Hu,2,3 Shupeng Chen,4 Yang Zhang5,6 1School of Clinical Chinese Medicine, Gansu University of Traditional Chinese Medicine, Gansu, People’s Republic of China; 2Teaching Experimental Training Center, Gansu University of Traditional ...
Song B, Hu J, Chen S, Zhang Y
doaj  

Qualidade de vida e inflamação das vias aéreas em diferentes níveis de controle da asma [PDF]

, 2013
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Ciências Médicas, Florianópolis, 2013.Introdução: A asma é uma doença inflamatória crônica das vias aéreas cujo objetivo principal ...
Rocha, Cristiane Cinara
core