The Role of Upper Airway Microbiome in the Development of Adult Asthma. [PDF]
Immune Netw, 2021 Clinical and molecular phenotypes of asthma are complex. The main phenotypes of adult asthma are characterized by eosinophil and/or neutrophil cell dominant airway inflammation that represent distinct clinical features. Upper and lower airways constitute a unique system and their interaction shows functional complementarity. Although human upper airway
Losol P, Choi JP, Kim SH, Chang YS.
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Effect of benralizumab treatment on the airway microbiome in COPD. [PDF]
ERJ Open ResBackgroundOne-third of patients with COPD have an eosinophilic inflammatory phenotype. Benralizumab is an afucosylated humanised monoclonal antibody that targets the interleukin-5 receptor α subunit, leading to rapid and near-complete eosinophil depletionviaantibody-dependent cellular cytotoxicity.
Haldar K +7 more
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The Cystic Fibrosis Airway Microbiome [PDF]
Cold Spring Harbor Perspectives in Medicine, 2013 Repeated pulmonary exacerbation and progressive lung function decline characterize cystic fibrosis (CF) disease, and represents one of the leading causes of mortality in this patient population. Recent studies have shown, using culture-independent assays, that multiple microbial species can be detected in airway samples from CF patients.
Lynch, Susan V., Bruce, Kenneth D.
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Preterm Infants’ Airway Microbiome: A Scoping Review of the Current Evidence [PDF]
NutrientsThe aim of this scoping review was to investigate and synthesize existing evidence on the airway microbiome of preterm infants to outline the prognostic and therapeutic significance of these microbiomes within the preterm population and identify gaps in ...
Chiara Nava +2 more
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Eosinophilic airway inflammation in asthmatic patients is associated with an altered airway microbiome [PDF]
Journal of Allergy and Clinical Immunology, 2017 Asthmatic patients have higher microbiome diversity and an altered composition, with more Proteobacteria and less Bacteroidetes compared with healthy control subjects. Studies comparing airway inflammation and the airway microbiome are sparse, especially in subjects not receiving anti-inflammatory treatment.We sought to describe the relationship ...
Asger Sverrild +8 more
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Human genetic associations of the airway microbiome in chronic obstructive pulmonary disease [PDF]
Respiratory ResearchLittle is known about the relationships between human genetics and the airway microbiome. Deeply sequenced airway metagenomics, by simultaneously characterizing the microbiome and host genetics, provide a unique opportunity to assess the microbiome-host ...
Jingyuan Gao +17 more
doaj +2 more sources
The Effects of Airway Microbiome on Corticosteroid Responsiveness in Asthma [PDF]
American Journal of Respiratory and Critical Care Medicine, 2013 Abstract Rationale The role of airway microbiome in corticosteroid response in asthma is unknown. Objectives To examine airway microbiome composition in patients with corticosteroid-resistant (CR) asthma and compare ...
Elena Goleva +2 more
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Towards airway microbiome engineering for improving respiratory health. [PDF]
Adv Drug Deliv RevThe known roles of human-associated microbes in health and disease have expanded in recent years. While the gut microbiome is the most well studied, the airway microbiome is gaining attention as an important gatekeeper of respiratory health. Compared to the gut, the airway microbiome has lower species complexity, greater niche stability, and represents
Hern KE, Prindle A.
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Environmental exposures, the oral–lung axis and respiratory health: The airway microbiome goes on stage for the personalized management of human lung function [PDF]
Microbial BiotechnologyThe human respiratory system is constantly exposed to environmental stimuli, sometimes including toxicants, which can trigger dysregulated lung immune responses that lead to respiratory symptoms, impaired lung function and airway diseases.
Junkal Garmendia +1 more
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Comparison of the upper and lower airway microbiome in early postoperative lung transplant recipients [PDF]
Microbiology SpectrumThe upper and lower respiratory tract may share microbiome because they are directly continuous, and the nasal microbiome contributes partially to the composition of the lung microbiome.
Chun-xi Li +6 more
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