Results 21 to 30 of about 15,388 (248)

The Upper and Lower Airway Microbiome in Severe Asthma

05.02 - Monitoring airway disease, 2022
Introduction: Severe asthma is complex and immunologically heterogenous; airways infection and innate immune dysregulation may confer inhaled corticosteroid resistance and remains clinically challenging. We hypothesise that marked airway microbiome compositional shifts in severe asthma represent a ‘treatable trait’, with dominance of pathogenic species,
Jabeen, M, Sanderson, N, Barber, C, Lau, LCK, Pavord, ID, Chauhan, A, Klenerman, P, Street, T, Howarth, P, Hinks, TSC   +9 more
openaire   +4 more sources

The Airway Microbiome and Metabolome in Preterm Infants: Potential Biomarkers of Bronchopulmonary Dysplasia [PDF]

Frontiers in Pediatrics, 2022
ObjectivesWe investigated the genomic and metabolic characteristics of the airway microbiome in mild, moderate, severe, and non-bronchopulmonary dysplasia (BPD) preterm infants and explored possible mechanisms underlying BPD.MethodsTwenty-eight preterm ...
Qi Xu, Qi Xu, Jialin Yu, Dong Liu, Qi Tan, Yu He   +5 more
doaj   +2 more sources

Laboratory contamination in airway microbiome studies [PDF]

BMC Microbiology, 2019
The low bacterial load in samples acquired from the lungs, have made studies on the airway microbiome vulnerable to contamination from bacterial DNA introduced during sampling and laboratory processing. We have examined the impact of laboratory contamination on samples collected from the lower airways by protected (through a sterile catheter ...
Christine Drengenes, Harald G. Wiker, Tharmini Kalananthan, Eli Nordeide, Tomas M. L. Eagan, Rune Nielsen   +5 more
openaire   +6 more sources

Microbial influencers: the airway microbiome’s role in asthma

The Journal of Clinical Investigation
Asthma is a common chronic respiratory disease affecting people of all ages globally. The airway hosts diverse microbial communities increasingly recognized as influential in the development and disease course of asthma.
Young Jin Kim, Supinda Bunyavanich
doaj   +3 more sources

Microbiome-emitted scents activate olfactory neuron-independent airway-gut-brain axis to promote host growth in Drosophila

Nature Communications
While it is now accepted that the microbiome has strong impacts on animal growth promotion, the exact mechanism has remained elusive. Here we show that microbiome-emitted scents contain volatile somatotrophic factors (VSFs), which promote host growth in ...
Jin-Woo Lee, Kyung-Ah Lee, In-Hwan Jang, Kibum Nam, Sung-Hee Kim, Minsoo Kyung, Kyu-Chan Cho, Ji-hoon Lee, Hyejin You, Eun-Kyoung Kim, Young Hoon Koh, Hansol Lee, Junsun Park, Soo-Yeon Hwang, Youn Wook Chung, Choong-Min Ryu, Youngjoo Kwon, Soung-Hun Roh, Ji-Hwan Ryu, Won-Jae Lee   +19 more
doaj   +2 more sources

A Refined View of Airway Microbiome in Chronic Obstructive Pulmonary Disease at Species and Strain-Levels

Frontiers in Microbiology, 2020
Little is known about the underlying airway microbiome diversity in chronic obstructive pulmonary disease (COPD) at in-depth taxonomic levels. Here we present the first insights on the COPD airway microbiome at species and strain-levels.
Zhang Wang, Haiyue Liu, Fengyan Wang
exaly   +3 more sources

Upper versus lower airway microbiome and metagenome in children with cystic fibrosis and their correlation with lung inflammation.

PLoS ONE, 2019
ObjectiveAirways of children with cystic fibrosis (CF) harbor complex polymicrobial communities which correlates with pulmonary disease progression and use of antibiotics.
Mariana E Kirst, Dawn Baker, Eric Li, Mutasim Abu-Hasan, Gary P Wang   +4 more
doaj   +2 more sources

The Upper Airway Microbiome in Bronchiectasis: Expanding the Landscape of Airway Dysbiosis. [PDF]

Am J Respir Crit Care Med
Guan WJ, Pan CX, Martinez-Garcia MA.
europepmc   +3 more sources

The gut–airway microbiome axis in health and respiratory diseases [PDF]

Nature Reviews Microbiology
Susan V Lynch, Mustafa Özcam
exaly   +2 more sources

Supplemental Oxygen Alters the Airway Microbiome in Cystic Fibrosis. [PDF]

mSystems, 2022
Features of the airway microbiome in persons with cystic fibrosis (pwCF) are correlated with disease progression. Microbes have traditionally been classified for their ability to tolerate oxygen.
Vieira J, Jesudasen S, Bringhurst L, Sui HY, McIver L, Whiteson K, Hanselmann K, O'Toole GA, Richards CJ, Sicilian L, Neuringer I, Lai PS.   +11 more
europepmc   +2 more sources