Results 41 to 50 of about 15,388 (248)

Signatures of COVID-19 Severity and Immune Response in the Respiratory Tract Microbiome

mBio, 2021
Viral infection of the respiratory tract can be associated with propagating effects on the airway microbiome, and microbiome dysbiosis may influence viral disease.
Carter Merenstein, Guanxiang Liang, Samantha A. Whiteside, Ana G. Cobián-Güemes, Madeline S. Merlino, Louis J. Taylor, Abigail Glascock, Kyle Bittinger, Ceylan Tanes, Jevon Graham-Wooten, Layla A. Khatib, Ayannah S. Fitzgerald, Shantan Reddy, Amy E. Baxter, Josephine R. Giles, Derek A. Oldridge, Nuala J. Meyer, E. John Wherry, John E. McGinniss, Frederic D. Bushman, Ronald G. Collman   +20 more
doaj   +1 more source

Inflammatory Endotype Associated Airway Microbiome in COPD Clinical Stability and Exacerbations - A Multi-Cohort Longitudinal Analysis [PDF]

, 2021
RATIONALE: Understanding the role of airway microbiome in chronic obstructive pulmonary disease (COPD) inflammatory endotypes may help to develop microbiome-based diagnostic and therapeutic approaches.OBJECTIVES: To understand the association of airway ...
Barer, Michael R, Donaldson, Gavin C, Wilkinson, Tom M A, Miller, Bruce E, Tal-Singer, Ruth, Wang, Zhang, Ma, Wei, Locantore, Nicholas, Ramsheh, Mohammadali Yavari, Haldar, Koirobi, Brown, James R, Bafadhel, Mona, Beech, Augusta S; id_orcid, Wedzicha, Jadwiga A, Singh, Dave, Brightling, Christopher E   +15 more
core   +1 more source

Cystic fibrosis microbiome: analysis of nasal middle meatus and sputum in different lung disease stages [PDF]

Rhinology Online, 2020
Background: Culture independent methods of molecular detection of microbiome have shown the polymicrobial nature of respiratory infections in cystic fibrosis, with pathogenic agents undetectable in conventional culture methods.
F.G.O. Maestrali, R.R.M. Pilan, R. Athanazio, L.G. Sparvoli, R.V. Cortez, C.R. Taddei, R.L. Voegels   +6 more
doaj   +1 more source

The importance of airway and lung microbiome in the critically ill [PDF]

Critical Care, 2020
AbstractDuring critical illness, there are a multitude of forces such as antibiotic use, mechanical ventilation, diet changes and inflammatory responses that could bring the microbiome out of balance. This so-called dysbiosis of the microbiome seems to be involved in immunological responses and may influence outcomes even in individuals who are not as ...
Ignacio Martin-Loeches 1 2 3, Robert Dickson 4 5 6, Antoni Torres 7, Håkan Hanberger 8 9, Jeffrey Lipman 10 11, Massimo Antonelli, Gennaro de Pascale, Fernando Bozza 14, Jean Louis Vincent 15, Srinivas Murthy 16, Michael Bauer 17, John Marshall 18, Catia Cilloniz 7, Lieuwe D Bos 19   +13 more
openaire   +9 more sources

Differences in airway microbiome and metabolome of single lung transplant recipients

Respiratory Research, 2020
Background Recent studies suggest that alterations in lung microbiome are associated with occurrence of chronic lung diseases and transplant rejection. To investigate the host-microbiome interactions, we characterized the airway microbiome and metabolome
Nirmal S. Sharma, Grant Vestal, Keith Wille, Kapil N. Patel, Feng Cheng, Srinivas Tipparaju, Sultan Tousif, Mudassir M. Banday, Xin Xu, Landon Wilson, Viswam S. Nair, Casey Morrow, Don Hayes, Andreas Seyfang, Stephen Barnes, Jessy S. Deshane, Amit Gaggar   +16 more
doaj   +1 more source

Divergent airway microbiomes in lung transplant recipients with or without pulmonary infection

Respiratory Research, 2021
Background Lung transplant (LTx) recipients are at increased risk for airway infections, but the cause of infection is often difficult to establish with traditional culture-based techniques.
Lisa I. Påhlman, Lokeshwaran Manoharan, Anna Stjärne Aspelund   +2 more
doaj   +1 more source

Polymicrobial airway bacterial communities in adult bronchiectasis patients [PDF]

, 2014
Background: Chronic airway infection contributes to the underlying pathogenesis of non-cystic fibrosis bronchiectasis (NCFBr). In contrast to other chronic airway infections, associated with COPD and CF bronchiectasis, where polymicrobial communities ...
Christopher J Stewart, Smith, Darren L., Jary, Hannah, Andrew Nelson, Perry, J. D. (John), Nelson, Andrew, Stewart, Christopher, Smith, Darren, Anthony De Soyza, Stephen P Cummings, Perry, A, John D Perry, Clare Lanyon, Purcell, Paul, Lanyon, Clare, Hannah Jary, Darren L Smith, Paul Purcell, de Soyza, Anthony, Perry, Audrey, Cummings, Stephen, Perry, John, Audrey Perry   +22 more
core   +1 more source

Inhaled nanomaterials and the respiratory microbiome: clinical, immunological and toxicological perspectives

Particle and Fibre Toxicology, 2018
Our development and usage of engineered nanomaterials has grown exponentially despite concerns about their unfavourable cardiorespiratory consequence, one that parallels ambient ultrafine particle exposure from vehicle emissions.
Tuang Yeow Poh, Nur A’tikah Binte Mohamed Ali, Micheál Mac Aogáin, Mustafa Hussain Kathawala, Magdiel Inggrid Setyawati, Kee Woei Ng, Sanjay Haresh Chotirmall   +6 more
doaj   +1 more source

Cardiorespiratory performance capacity and airway microbiome in patients following primary repair of esophageal atresia [PDF]

, 2021
BACKGROUND: Patients following repair of an esophageal atresia (EA) or tracheoesophageal fistula (TEF) carry an increased risk of long-term cardiopulmonary malaise. The role of the airway microbiome in EA/TEF patients remains unclear. METHODS: All EA/TEF
Till, Holger, Singer, Georg, Bernhard Kienesberger, Arneitz, Christoph, Klymiuk, Ingeborg, Christoph Arneitz, Kienesberger, Bernhard, Christoph Castellani, Holger Till, Windhaber, Jana, Castellani, Christoph, Günter Fasching, Georg Singer, Ingeborg Klymiuk, Fasching, Günter, Jana Windhaber   +15 more
core   +1 more source

The microbiome of the upper airways: focus on chronic rhinosinusitis [PDF]

World Allergy Organization Journal, 2015
Upper airway diseases including allergic rhinitis, chronic rhinosinusitis with or without polyps, and cystic fibrosis are characterized by substantially different inflammatory profiles. Traditionally, studies on the association of specific bacterial patterns with inflammatory profiles of diseases had been dependent on bacterial culturing.
Chalermwatanachai, Thanit, Velasquez, Leydi, Bachert, Claus   +2 more
openaire   +4 more sources