Results 61 to 70 of about 96,005 (269)

Histone Deacetylase 6 (HDAC6) in Ciliopathies: Emerging Insights and Therapeutic Implications

Advanced Science, EarlyView.
HDAC6 regulates primary cilia, crucial for cellular signalling and environmental responses. Dysregulation of HDAC6 contributes to ciliopathies, affecting multiple organs. This review examines HDAC6's role in ciliogenesis, its interaction with signaling molecules, and its potential as a therapeutic target.
Zhiyi Wang, Xiaofan Zhu, Zhenzhou Huang, Kaidi Ren, Jie Ran, Yang Yang   +5 more
wiley   +1 more source

Prevalence, clinical characteristics, and predictors of sleep disordered breathing in hospitalized heart failure patients

Clinical Cardiology, Volume 45, Issue 12, Page 1311-1318, December 2022., 2022
Abstract Background Heart failure (HF) is often comorbid with sleep disordered breathing (SDB). This prospective study investigated the prevalence, clinical characteristics, and predictors of SDB in hospitalized HF patients. Methods Sleep studies were performed on hospitalized HF patients from January 2015 to February 2019.
Boping Huang, Yan Huang, Mei Zhai, Qiong Zhou, Shiming Ji, Huihui Liu, Xiaofeng Zhuang, Yuhui Zhang, Jian Zhang   +8 more
wiley   +1 more source

Post-Obstructive Pulmonary Edema: A Different Type of Pulmonary Edema

Amrita Journal of Medicine
Post-obstructive pulmonary edema (POPE) or negative pressure pulmonary edema is a unique clinical entity occurring in the context of airway obstruction. Two distinct subclasses of POPE have been described in literature: type I occurring in the setting of
Srikant K. Malegaonkar
doaj   +1 more source

Unwrapping the Ciliary Coat: High‐Resolution Structure and Function of the Ciliary Glycocalyx

Advanced Science, EarlyView.
The ciliary membrane is decorated in glycosylated proteins that define the interaction of the cilium with its environment. The main component of the ciliary coat of the green alga Chlamydomonas reinhardtii, FMG1, is characterized by cryo‐electron microscopy, proteomics, and live cell microscopy with flow‐based adhesion assays.
Lara M. Hoepfner, Adrian P. Nievergelt, Fabrizio Matrino, Martin Scholz, Helen E. Foster, Jonathan Rodenfels, Alexander von Appen, Michael Hippler, Gaia Pigino   +8 more
wiley   +1 more source

Pharmacokinetics and Bioequivalence of Fudosteine in Healthy Chinese Volunteers Under Fasting and Fed Conditions: A 4‐Way Replicate Crossover Study

Clinical Pharmacology in Drug Development, Volume 12, Issue 1, Page 30-37, January 2023., 2023
Abstract The bioequivalence of a generic fudosteine tablet vs a brand‐named fudosteine tablet under fasting and fed conditions was evaluated in this study. This randomized, open‐label, single‐dose, 4‐way replicate, crossover, bioequivalence study included 64 healthy Chinese subjects (fasting cohort, n = 32; fed cohort, n = 32) who were assigned to ...
Mingxue Zhu, Yi Tao, Junliang Pu, Hongtao Zhao, Lei Wan, Peilin Zhang, Chengyong Tang   +6 more
wiley   +1 more source

Modelling the human pharyngeal airway: validation of numerical simulations using in vitro experiments [PDF]

Med Biol Eng Comput (2008) epub ahead of print, 2008
In the presented study, a numerical model which predicts the flow-induced collapse within the pharyngeal airway is validated using in vitro measurements. Theoretical simplifications were considered to limit the computation time. Systematic comparisons between simulations and measurements were performed on an in vitro replica, which reflects asymmetries
arxiv   +1 more source

ADAR1‐HNRNPL‐Mediated CircCANX Decline Promotes Autophagy in Chronic Obstructive Pulmonary Disease

Advanced Science, EarlyView.
ADAR1‐HNRNPL interaction‐repressed circCANX recruits P53 mRNA and UPF1 to assemble a complex in nuclear. This complex promotes P53 mRNA degradation through the NMD pathway, and finally reduces autophagy and stress granules formation to further regulate inflammation.
Ting‐Ting Chen, Yuan‐Yuan Wei, Jia‐Ying Kang, Da‐Wei Zhang, Jing‐Jing Ye, Xi‐Shi Sun, Mei Hong, Wen‐Ting Zhang, Hui‐Mei Wu, Zhen‐Xing Ding, Guang‐He Fei   +10 more
wiley   +1 more source

The comparison of two different mandibular positions for oral appliance therapy in patients with obstructive sleep apnea

Clinical and Experimental Dental Research, Volume 8, Issue 6, Page 1567-1574, December 2022., 2022
Abstract Background An oral appliance (OA) can alleviate upper airway obstruction by pulling the mandible forward during sleep. While a large mandibular advancement with an OA decreases the number of apnea and hypopnea events, long‐term use may cause side effects, such as toothache, stiffness, and pain in the temporomandibular joint.
Eri Makihara, Takafumi Watanabe, Hiromichi Ogusu, Shin‐Ichi Masumi   +3 more
wiley   +1 more source

The site of airway obstruction among patients of emphysema: Role of impulse oscillometry

Lung India, 2008
Objectives: To detect the site of airway obstruction in patients of emphysema by impulse oscillometry (IOS) and to compare its observatios with flow volume loop (FV loop) studies.
Hira H, Munjal Jitendra, Zachariah Sanjay, Chauhan M, Singh Anshu   +4 more
doaj  

Curvature-driven transport of thin Bingham fluid layers in airway bifurcations [PDF]

arXiv, 2021
The mucus on the bronchial wall forms a thin layer of non-Newtonian fluid. One of the roles of mucus is to protect the lungs by capturing inhaled pollutants. It is transported by mucocilliary clearance toward the tracheo-pharyngeal bifurcation, where it is eliminated.
arxiv