Results 121 to 130 of about 77,336 (300)
Flavour and Fragrance Journal, EarlyView.We unveil that CLC orchestrates the dual role of eosinophil recruitment via CCL26 and tissue remodelling via POSTN in allergic rhinitis, identifying it as a potential therapeutic target. ABSTRACT Allergic rhinitis (AR) is a chronic airway inflammation driven by a type 2 immune response, yet the molecular mechanisms underlying its persistence and tissue
Fanyu Yuan +9 more
wiley +1 more source
Flavour and Fragrance Journal, EarlyView.This study demonstrates that resveratrol alleviates allergic rhinitis by activating SIRT1, thereby disrupting the mitochondrial ROS‐inflammatory cycle, improving mitochondrial function, promoting anti‐inflammatory M2 macrophage polarisation, and reducing epithelial oxidative damage.
Xinyu Zhou +6 more
wiley +1 more source
The Endothelial CXCR Family in Vascular Health and Disease
iNew Medicine, EarlyView.ABSTRACT Endothelial cells (ECs) form the dynamic interface between blood and tissue, serving as key regulators of vascular homeostasis, inflammation, and repair. Among the molecular systems governing endothelial behavior, the C‐X‐C motif chemokine receptor (CXCR) family—originally characterized in immunology for its roles in leukocyte trafficking and ...
Zhiming Wu +4 more
wiley +1 more source
The Role of Endothelin‐1 in Autoimmune Diseases: Mechanistic Insights and Therapeutic Targets
iNew Medicine, EarlyView.The Role of Endothelin‐1 in Autoimmune Diseases. NF‐κB: nuclear factor kappa‐B; MAPK: mitogen‐activated protein kinase; PI3K: phosphoinositide 3‐kinase; ROS: reactive oxygen species; CTGF: connective tissue growth factor; TGF‐β: transforming growth factor‐β.
Xun Gong +5 more
wiley +1 more source
Bitter Taste Receptors for Asthma Therapeutics. [PDF]
, 2019 Clinical management of asthma and chronic obstructive pulmonary disease (COPD) has primarily relied on the use of beta 2 adrenergic receptor agonists (bronchodilators) and corticosteroids, and more recently, monoclonal antibody therapies (biologics ...
Deshpande, Deepak A. +3 more
core +1 more source
Paediatrica Indonesiana, 2001 Airway remodeling is the term given to a series of structural changes characterized by chronic, irreversible airway obstruction. Structural changes in the airway wall caused by chronic inflammation of asthma. Evidence for asthma airway remodeling demonstrating an accelerated decline of lung function that cannot be completely reversed with therapy ...
Roni Naning, MTS Darmawan
openaire +2 more sources
Journal of Applied Toxicology, EarlyView.ABSTRACT This study aimed to evaluate the toxicological effects of occupational exposure to factory‐derived particulate matter (PM2.5) on human skin, emphasizing its role as a potential target organ of environmental toxicants. An epidemiological survey comparing factory and nonfactory workers was conducted by assessing their skin elasticity and color ...
Miku Tanaka +7 more
wiley +1 more source
Journal of Magnetic Resonance Imaging, EarlyView.ABSTRACT Background Upper‐airway morphology changes during breathing can be captured with cine 4D MRI. Active‐learning nnU‐Net reduces manual labeling while maintaining accuracy. Purpose For automatic upper airway segmentation on free‐breathing cine 4D MRI using active learning and quantifying dynamic changes under two mouth positions.
Cheng‐Yang Yu +7 more
wiley +1 more source
Role of inflammatory cells in airway remodeling in COPD
International Journal of COPD, 2018 Yujie Wang,1,2 Jiayan Xu,1 Yaqi Meng,1 Ian M Adcock,3 Xin Yao1 1Department of Respiratory Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China; 2Department of Respiratory Medicine, The Second Affiliated Hospital of ...
Wang Y, Xu J, Meng Y, Adcock IM, Yao X
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