Results 141 to 150 of about 45,718 (290)

Single‐Cell Profiling Identifies CLEC5A+ Macrophages as Key Drivers of Thoracic Aortic Aneurysm Via CCL5‐Mediated M1 Polarization

Journal of Clinical Laboratory Analysis, EarlyView.
Thoracic aortic aneurysm (TAA) is a life‐threatening cardiovascular disease with limited therapeutic options. Through single‐cell RNA sequencing of aortic tissues from healthy individuals and TAA patients (105,541 cells), we identified CLEC5A+macrophages as the predominant pathogenic cell population exhibiting the highest M1 polarization score. Machine
Xiangyu Li, Chunguang Guo, Mingyao Luo, Chang Shu   +3 more
wiley   +1 more source

Patient‐Reported Outcomes of Palatopharyngeal Surgery Without Tonsillectomy: A Meta‐Analysis

The Laryngoscope, EarlyView.
Palatopharyngeal surgery without tonsillectomy leads to clinically meaningful improvements in daytime sleepiness and snoring, but patient‐reported outcomes vary markedly by surgical technique. Suture‐based procedures, muscle relocation, cold‐steel approaches, and powered instruments show the largest and durable benefits, with no evidence of effect ...
Samuel Tschopp, Flora Meinert, Georgios Mantokoudis, Marco Caversaccio, Urs Borner   +4 more
wiley   +1 more source

Utility of Preoperative Cardiac Workup for Children With Very Severe Obstructive Sleep Apnea

The Laryngoscope, EarlyView.
In this retrospective study, we aimed to examine the prevalence and utility of obtaining a preoperative cardiac workup in children with very severe obstructive sleep apnea (OSA) prior to adenotonsillectomy. Of 144 patients with very severe OSA, 38 patients (26.4%) underwent a preoperative cardiac workup, and three of those 38 had abnormal findings ...
Danny A. Elias, Amber D. Shaffer, Zachary Bennett, Rachel Whelan   +3 more
wiley   +1 more source

Eosinophils Play Significant Role in Airway Remodeling via Integrin Interactions with Airway Structural Cells

, 2018
Asthma is a chronic respiratory disease causing inflammation and remodeling of the lungs and airways. There are two broad phenotypes of asthma, allergic and non-allergic asthma, in which allergic asthma is dependent on allergens and a type 2 immune ...
Lor, Mina
core  

Toxicity Differences Between Microplastics and Nanoplastics in Organs: From Molecular Mechanisms to Potential Therapeutic Strategies

Med Research, EarlyView.
This review systematically compares the size‐dependent toxicity of microplastics and nanoplastics in the intestine, liver, kidney, lung, and brain. Particle size determines bioavailability, barrier penetration, and injury mechanisms. Because of their small size and high surface reactivity, NPs readily cross the intestinal epithelium and blood–brain ...
Yixian Cheng, Junjie Chen, Rui Fu, Jiawei Zhang, Jianguang Jia, Wei Wang, Zheng Zhang, Peng Zhang, Haosong Chen, Huake Cao, Gang Li, Weiwei Sheng, Ting Li, Bo Chen, Guodong Cao   +14 more
wiley   +1 more source

Autophagy is selectively activated and correlates with airway remodeling in asthma

, 2019
Current asthma therapies fail to target airway remodeling that correlates with asthma severity driving disease progression that ultimately leads to loss of lung function.
Xenaki, D (15679547), Deshpande, DA (15679553), Ghavami, S (15693548), Oliver, BG (15679550), McAlinden, KD (15693545), Sukhwinder Sohal (14749798), Haghi, M (15693551), Sharma, P (15560492)   +7 more
core  

The Role of Polyphenols in Respiratory and Gut Health: From the Perspective of Gut‐Lung Axis

Phytotherapy Research, EarlyView.
ABSTRACT The gut‐lung axis constitutes a dynamic, multidirectional communication platform between the gastrointestinal and respiratory tracts. Its complexity arises from the integrated crosstalk among the microbiota, immune system, and redox homeostasis, collectively influencing disease susceptibility and progression.
Jian Kang, YongJun Du, Yanmei Hou, Liangliang Hao, Zhen Chen, Haoyang Xie, Chuantao Zhang, Lei Li   +7 more
wiley   +1 more source

Responsive nitric oxide‐releasing antibacterial materials for biofilm‐associated infections: Mechanisms, design strategies, and applications

Responsive Materials, EarlyView.
This review summarizes the recent progress in responsive NO‐releasing materials and their applications in biofilm‐associated infectious diseases. The design principles and response mechanisms are given to provide inspiration toward the future development of multi‐responsive NO‐releasing materials.
Wenyue Sun, Meiqi Li, Di Nan, Jiaqi Zhao, Yu Chen, Yao Gao, Shichen Zhang, Kirsten L. Van Landuyt, Manlin Qi   +8 more
wiley   +1 more source

Airway Remodeling in Chronic Obstructive Pulmonary Disease (COPD), a Review

, 2013
Chronic obstructive pulmonary disease (COPD) is a major cause of chronic disability and mortality worldwide. Pathologically, it is a complex disease involving structural changes in lung parenchyma, airways, and vessels.
Eugene Walters (14752090), Reid, D (15531989), Wood-Baker, R (15478649), Soltani , A (15817793), Sukhwinder Sohal (14749798)   +4 more
core  

Diving Deeper Into Mechanisms of Acrylamide‐Induced Toxicity: RNA Sequencing Reveals Transcriptomic Alteration and Retrotransposon Expression in Drosophila melanogaster

Environmental Toxicology, EarlyView.
ABSTRACT Given the inevitability of human and animal exposure to acrylamide, there is increasing concern regarding its potential health risks. While a number of molecular mechanisms have been proposed, the complexity of acrylamide toxicological pathways and interactions remains incompletely characterized.
Oluwabukola Mary Farodoye, Titilayomi Ayomide Otenaike, Daniela Moreira Mombach, Monica Medeiros Silva, Amos Olalekan Abolaji, Elgion Lucio Da Silva Loreto   +5 more
wiley   +1 more source