Results 121 to 130 of about 365,854 (289)

Role of inflammatory cells in airway remodeling in COPD

International Journal of COPD, 2018
Yujie Wang,1,2 Jiayan Xu,1 Yaqi Meng,1 Ian M Adcock,3 Xin Yao1 1Department of Respiratory Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China; 2Department of Respiratory Medicine, The Second Affiliated Hospital of ...
Wang Y, Xu J, Meng Y, Adcock IM, Yao X
doaj  

Air Pollution Quinones Impair Intestinal Barrier Integrity and Endoplasmic Reticulum in Differentiated Caco‐2 Cells

Journal of Applied Toxicology, EarlyView.
ABSTRACT Particulate matter (PM) is a major global health threat, linked to millions of deaths annually. Beyond inhalation, PM components reach the gastrointestinal tract through the mucociliary escalator or contaminated food and water. Among PM's organic fraction, redox‐active quinones such as 1,2‐naphthoquinone (NQ) and 9,10‐phenanthrenequinone (PQ ...
Franco Cervellati, Giulia Trinchera, Alice Casoni, Alessandra Pecorelli, Mascia Benedusi, Maria Chiara Pietrogrande, Giuseppe Valacchi   +6 more
wiley   +1 more source

Single‐Cell Profiling Identifies CLEC5A+ Macrophages as Key Drivers of Thoracic Aortic Aneurysm Via CCL5‐Mediated M1 Polarization

Journal of Clinical Laboratory Analysis, EarlyView.
Thoracic aortic aneurysm (TAA) is a life‐threatening cardiovascular disease with limited therapeutic options. Through single‐cell RNA sequencing of aortic tissues from healthy individuals and TAA patients (105,541 cells), we identified CLEC5A+macrophages as the predominant pathogenic cell population exhibiting the highest M1 polarization score. Machine
Xiangyu Li, Chunguang Guo, Mingyao Luo, Chang Shu   +3 more
wiley   +1 more source

Diaphragm Ultrasonography Reveals Progressive Changes in Diaphragmatic Function, Morphology, and Muscle Trophism During Invasive Mechanical Ventilation in Children

Journal of Clinical Ultrasound, EarlyView.
Diaphragm ultrasonography detected progressive structural and functional deterioration in mechanically ventilated children. Prolonged invasive mechanical ventilation and neuromuscular blocking agent use were associated with ventilator‐induced diaphragmatic dysfunction, highlighting ultrasound as a valuable bedside tool to support individualized ...
Juliana Bezerra dos Santos, Emmerson Carlos Franco de Farias, Mary Lucy Ferraz Maia Fiuza de Mello, Rodrigo Santiago Barbosa Rocha   +3 more
wiley   +1 more source

Mechanism of RNA‐Binding Protein ELAVL1 in Promoting Th2 Cell Differentiation Through Stabilizing CPA3 mRNA in Allergic Rhinitis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT This study aimed to elucidate the role of the RNA‐binding protein embryonic lethality abnormal vision‐like protein 1 (ELAVL1) in the pathogenesis of allergic rhinitis (AR), specifically by investigating its potential to promote T helper 2 (Th2) cell differentiation by regulating the stability of carboxypeptidase A3 (CPA3) mRNA.
Meng‐Ya Liu, Hong‐Bing Yao, Cheng Chen   +2 more
wiley   +1 more source

KCNJ2 is Required for NLRP3 Inflammasome Activation That Drives Allergic Airway Inflammation and Remodeling

Advanced Science
Airway inflammation and remodeling are cardinal features of asthma pathogenesis. Genome‐wide association studies have shown that several SNPs of KCNJ2, a member of the inwardly rectifying potassium channel family, are associated with asthma in patients ...
Yachao Cui, Shumei Wu, Yang Peng, Yiqi Liu, Li Che, Shiying Chen, Feng Zhang, Dajiang Qin, Shiyue Li, Pixin Ran, Wenguang Yin   +10 more
doaj   +1 more source

Airway structural components drive airway smooth muscle remodeling in asthma

, 2009
Chronic asthma is an inflammatory airways disease characterized by pathological changes in the airway smooth muscle (ASM) bundle that contribute to airway obstruction and hyperresponsiveness.
Dekkers, Bart G J, Maarsingh, Harm, Meurs, Herman, Gosens, Reinoud, Dekkers, Bart G J; id_orcid   +4 more
core   +1 more source

Effect of Notch1 on Vocal Fold Re‐Epithelization After Acute Injury

The Laryngoscope, EarlyView.
Conditional deletion of Notch1 in Lrig1‐expressing vocal fold epithelial cells impaired re‐epithelialization following naphthalene injury, resulting in sustained basal cell proliferation, abnormal epithelial differentiation, and prolonged inflammatory cell infiltration.
Jie Cai, Susan L Thibeault, Vlasta Lungova   +2 more
wiley   +1 more source

Evaluating the Local Response of a Novel Injectable Capsule for Drug Delivery in the Trachea

The Laryngoscope, EarlyView.
A novel PLGA polymer capsule was developed for localized pretracheal drug delivery and evaluated for short‐term local tissue safety in a rabbit model. Implant placement was confirmed by ultrasound and was well tolerated over 14 days, with preservation of airway patency, native tracheal architecture, and biomechanical properties.
Denzel Ryan D. Cruz, Nour Awad, Nicholas Russell, Juliana El Sheikh, Logan Obermeyer, Peter J. Larson, Yoonjee C. Park, Gregory R. Dion   +7 more
wiley   +1 more source

The eosinophil and airway remodelling in asthma

The Clinical Respiratory Journal, 2010
AbstractObjectives:  Eosinophils are common findings cells in allergic asthma as is sub‐base membrane thickening of the airways. The objective of this review was to summarise some recent findings linking the activities of eosinophils to airways remodelling.Data Source and Study Selection:  The study used a review of current literature with emphasis on ...
openaire   +2 more sources