Results 111 to 120 of about 45,718 (290)
Novel Organelle‐Based Intracellular Immunity With Mechanistic and Therapeutic Implications
Barrier Immunity, EarlyView.A conceptual framework illustrating how PAMPs/DAMPs initiate barrier, innate, adaptive, and intracellular immune responses, with organelle‐based intracellular immunity serving as a central integrator linking metabolism, inflammatory signaling, and therapeutic interventions to restore immune homeostasis.
Keman Xu +9 more
wiley +1 more source
The eosinophil and airway remodelling in asthma
The Clinical Respiratory Journal, 2010 AbstractObjectives: Eosinophils are common findings cells in allergic asthma as is sub‐base membrane thickening of the airways. The objective of this review was to summarise some recent findings linking the activities of eosinophils to airways remodelling.Data Source and Study Selection: The study used a review of current literature with emphasis on ...
openaire +2 more sources
Biophysical processes of morphogenesis in lizard lungs
Developmental Dynamics, EarlyView.Abstract Background The lungs of squamate reptiles (lizards and snakes) are highly diverse, exhibiting single chambers, multiple chambers, transitional forms with two to three chambers, along with a suite of other anatomical features, including finger‐like epithelial projections into the body cavity known as diverticulae.
Kaleb Hill +9 more
wiley +1 more source
Developmental Dynamics, EarlyView.Abstract Background Fibrillins provide a scaffold for elastic fiber formation, which enables lung recoil and aortic compliance. Abnormal fibrillin microfibrils, as in Marfan syndrome, lead to enlarged alveoli, vascular stiffening, and aneurysms. Our earlier studies suggested that fibrillin function depends on O‐glucosylation of its epidermal growth ...
Sanjiv Neupane +4 more
wiley +1 more source
Imperatorin alleviates ROS-mediated airway remodeling by targeting the Nrf2/HO-1 signaling pathway
, 2020 In this study, we investigated the role and mechanism of imperatorin (IMP) in chronic inflammation and airway remodeling. The levels of TNF-α, IL-1β, IL-6, IL-8, VEGF, α-SMA, and ROS were detected by ELISA, immunohistochemistry (IHC), immunofluorescence,
Chongyang Wang (1446037) +10 more
core +1 more source
Biomarkers of lung congestion and injury in acute heart failure
ESC Heart Failure, Volume 12, Issue 2, Page 781-789, April 2025.Abstract Acute heart failure (AHF) classification and management are primarily based on lung congestion and/or hypoperfusion. The quantification of the vascular and tissue lung damage is not standard practice though biomarkers of lung injury may play a relevant role in this context.
Marco Guazzi +9 more
wiley +1 more source
Correlation Between HIF1-A Expression and Airway Remodeling in COPD
Lingfang Tan,1 Xuefeng Yang,2 Jianxin Zhang,3 Kebing Zhou1,2 1The Nanhua Affiliated Hospital, Department of Respiratory Physicians, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, People’s Republic of China; 2The Nanhua ...
Tan L, Yang X, Zhang J, Zhou K
core +1 more source
Airway remodeling blockade with an orally active geranyl acetophenone [PDF]
, 2017 n the last few decades, structural changes of airways in asthma has gained huge attention from both clinicians and scientists as current therapeutic approaches are inadequate in attenuating airway remodeling, especially in severe asthma patients.
Lee, Yu Zhao
core
Equine Veterinary Journal, EarlyView.Abstract Background The molecular mechanisms underlying adaptation to physical exertion and racing stress in horses remain incompletely understood. Peripheral blood transcriptomics offers a minimally invasive method to monitor systemic responses to exercise and identify biomarkers of adaptation or overload. Objectives To evaluate transcriptomic changes
Izabela Dąbrowska +4 more
wiley +1 more source
AR inhibition prevents airway remodeling in chronic asthma.
, 2013 Besides stimulating Smad-dependent signals, TGFβ1 is known to stimulate PI3K/AKT/GSK3β pathway which plays an important role in airway remodeling (discussed in the text).
Istvan Boldogh (16539) +7 more
core +1 more source