Results 91 to 100 of about 365,854 (289)

Research progress on the role of airway epithelial-mesenchymal transition in airway remodeling in asthma

Guangxi Yike Daxue xuebao
Bronchial asthma is a heterogeneous disease characterized by chronic airway inflammation, reversible airflow limitation and airway remodeling. Airway remodeling is the key pathological basis for the progression of mild asthma to severe and refractory ...
Liping Xu, Jingmin Deng
doaj   +1 more source

Three‐dimensional geometric morphometric analysis of diaphragmatic dome motion in COPD patients

The Anatomical Record, EarlyView.
Abstract Diaphragmatic dysfunction is a hallmark of chronic obstructive pulmonary disease (COPD), especially in emphysema, where hyperinflation alters diaphragm geometry and impairs inspiratory mechanics. However, quantitative three‐dimensional (3D) assessments of diaphragmatic dome shape and motion across COPD phenotypes are limited.
José M. López‐Rey, Benoît Beyer, Elena García‐Vargas, Isabel Torres‐Sánchez, Francisco García‐Río, Markus Bastir   +5 more
wiley   +1 more source

Radiological Approach to Asthma and COPD-The Role of Computed Tomography

Allergology International, 2009
Asthma and chronic obstructive pulmonary disease (COPD) are among the most prevalent lung diseases. In both asthma and COPD, airway inflammation leads to airway remodeling. Parenchyma of the lung is also influenced by disease conditions.
Yasutaka Nakano, Nguyen Van Tho, Hideto Yamada, Makoto Osawa, Taishi Nagao   +4 more
doaj   +1 more source

ORMDL3 Transgenic Mice Have Increased Airway Remodeling and Airway Responsiveness Characteristic of Asthma [PDF]

, 2014
Orosomucoid-like (ORMDL)3 has been strongly linked with asthma in genetic association studies. Because allergen challenge induces lung ORMDL3 expression in wild-type mice, we have generated human ORMDL3 zona pellucida 3 Cre (hORMDL3(zp3-Cre)) mice that ...
Suzukawa, Maho, Niwa, Maho, McGeough, Matthew D, Beppu, Andrew, Hoffman, Hal M, Pena, Carla A, Tam, Arvin B, Rosenthal, Peter, Mueller, James L, Doherty, Taylor A, Broide, David H, Miller, Marina   +11 more
core   +1 more source

Comparative Transcriptional Profiling of Key Macrophage and Fibroblast Subpopulations in Rheumatoid Arthritis–Associated Lung Disease

Arthritis &Rheumatology, EarlyView.
Objective Rheumatoid arthritis (RA) often involves extra‐articular complications, including interstitial lung disease (ILD) and/or pulmonary nodules. Transcriptomic profiling of lung tissue provides the opportunity to directly assess cell‐specific gene expression and corresponding pathway activation in different types of rheumatoid lung disease ...
Tracy Tabib, Ogechukwu Ezenwa, Joshua Sciurba, Eleanor B. Valenzi, John Sembrat, Brittany Cody, Jishnu Das, Robert Lafyatis, Dana P. Ascherman   +8 more
wiley   +1 more source

Correlation Between HIF1-A Expression and Airway Remodeling in COPD [PDF]

Lingfang Tan,1 Xuefeng Yang,2 Jianxin Zhang,3 Kebing Zhou1,2 1The Nanhua Affiliated Hospital, Department of Respiratory Physicians, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, People’s Republic of China; 2The Nanhua ...
Tan L, Yang X, Zhang J, Zhou K
core  

Plasma proteome reflects tissue damage and clinical manifestations in patients with inflammatory myopathies

Arthritis &Rheumatology, Accepted Article.
Objective Tissue‐specific biomarkers that are reliable and associated with clinical manifestations of idiopathic inflammatory myopathy (IIM) are lacking. The blood circulation in individuals serves as a central conduit, allowing communication between tissues and facilitating clearance and recycling of tissue‐derived proteins.
Yue‐Bei Luo, Josefin Kenrick, Angeles S Galindo‐Feria, Antonella Notarnicola, Ana Daniela Ulloa Navas, Irene Peralta‐Garcia, Orane Demuynck, Andrea Kemp, Valérie Leclair, Karin Lodin, Eveline Van Gompel, Lara Dani, Fabricio Espinosa‐Ortega, Maryam Dastmalchi, Leonid Padyukov, Charlotta Preger, María Bueno Álvez, Mathias Uhlén, Peter Nilsson, Fredrik Edfors, Lina‐Marcela Diaz‐Gallo, Elisa Pin, Ingrid E Lundberg, Begum Horuluoglu   +23 more
wiley   +1 more source

Low-Dose Azithromycin Attenuates OVA-Induced Airway Remodeling and Inflammation via Down-Regulating TGF-βl Expression in RAT

European Journal of Inflammation, 2013
Asthma is characteristic with chronic airway inflammation and remodeling. Azithromycin (AZM), the 15-member macrolide, is known to present an anti-inflammatory effect and is increasingly being used in the treatment of chronic inflammatory pulmonary ...
L. Wan, L. Liu, Z. Zhang, Y. Zhou, Y. Xiong, D. Li, L. Zhou   +6 more
doaj   +1 more source

Purification of Advanced Therapeutics by Flow‐Through Pseudo‐Affinity Chromatography: Bi‐Specific mABs, Fc Fusion Proteins, and Adeno‐Associated Viruses

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Modern biopharmaceutical manufacturing requires purification platforms capable of processing structurally and functionally diverse products while addressing the challenge of removing persistent and high‐risk host cell proteins (HCPs).
Wenning Chu, Eduardo Barbieri, Arianna Minzoni, Shriarjun Shastry, Jacob P. LeBarre, Qingbo Shu, Taufika Williams, Xuanwen Li, Divya Chandra, Xuankuo Xu, Jerome Bill, David Roush, Joseph Taris, Patrick Gilbert, Andre Kiesewetter, Oliver Rammo, Michael Schulte, Christopher Major, Trina Mouchahoir, Steven Cramer, Cristiana Boi, Ruben G. Carbonell, Abraham Lenhoff, Stefano Menegatti   +23 more
wiley   +1 more source

Airway function at one year: association with premorbid airway function, wheezing, and maternal smoking [PDF]

, 2001
Background - Impaired growth and development of the respiratory system during fetal and early postnatal life may have important implications for lung development and later lung health.
Wade, AM, Wade, A. M., Fletcher, M. E., C Dezateux, Dezateux, C., Dundas, I, Fletcher, ME, Stocks, J., Dundas, I., Stocks, J, Fletcher, Margaret, Dezateux, C   +11 more
core   +1 more source