Results 81 to 90 of about 397,469 (244)

Microbial‐Metabolite Signatures Are Associated With Glucocorticoid Responsiveness in Chronic Rhinosinusitis With Nasal Polyps

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Patients with chronic rhinosinusitis with nasal polyps (CRSwNP) exhibit heterogeneous responses to oral glucocorticoids (GCs), but the biological basis of this variability remains unclear. Objective To identify gut microbiome‒plasma metabolomic signatures associated with GC responsiveness in CRSwNP patients and to compare their ...
Ying‐Ying Zhang, Xin‐Yu Ding, Mei‐Ping Lu, Yan‐Bing Chen, Ye Yuan, Lin Jiang, Min Zhang, Lei Cheng   +7 more
wiley   +1 more source

Research progress on the role of airway epithelial-mesenchymal transition in airway remodeling in asthma

Guangxi Yike Daxue xuebao
Bronchial asthma is a heterogeneous disease characterized by chronic airway inflammation, reversible airflow limitation and airway remodeling. Airway remodeling is the key pathological basis for the progression of mild asthma to severe and refractory ...
Liping Xu, Jingmin Deng
doaj   +1 more source

Functional Specialization of Respiratory and Olfactory Mucus Revealed by Proteomic Profiling

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Mucus overlies the nasal mucosa in the respiratory and olfactory regions, which perform distinct physiological functions. However, proteomic differences between respiratory mucosa (RM) and olfactory cleft (OC) mucus remain unclear.
Anna Kristina Hernandez, Karoline Lantzsch, Romain Topalian, Nadine Gunder, Philipp Hubel, Katharina Schindowski, Jens Pfannstiel, Thomas Hummel   +7 more
wiley   +1 more source

Radiological Approach to Asthma and COPD-The Role of Computed Tomography

Allergology International, 2009
Asthma and chronic obstructive pulmonary disease (COPD) are among the most prevalent lung diseases. In both asthma and COPD, airway inflammation leads to airway remodeling. Parenchyma of the lung is also influenced by disease conditions.
Yasutaka Nakano, Nguyen Van Tho, Hideto Yamada, Makoto Osawa, Taishi Nagao   +4 more
doaj   +1 more source

Mepacrine treatment attenuates allergic airway remodeling segregated from airway inflammation in mice

, 2011
Asthma is a chronic airway disease characterized by increased airway hyperresponsiveness, airway inflammation, and airway remodeling including collagen deposition in subepithelial regions.
Balaram Ghosh, Ghosh, Balaram, Ahmad, Tanveer, Agrawal, Anurag, Hasija, Kanika, Mabalirajan, Ulaganathan, Ulaganathan Mabalirajan, Kanika Hasija, Anurag Agrawal, Tanveer Ahmad   +9 more
core   +1 more source

Poly(I:C)‐Activated Nasal Fibroblasts Promote Eosinophil Recruitment in CRSwNP

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by persistent mucosal inflammation and eosinophilic infiltration. Although epithelial and immune cells have been widely studied, the role of nasal fibroblasts in innate immune activation and eosinophil recruitment remains unclear.
Chaewon Shin, An‐Gi Kim, Byeong Min Yu, Woo‐Keun Kwon, Min‐Ho Hwang, Joo‐Hoo Park   +5 more
wiley   +1 more source

Olfactory Function in Cystic Fibrosis: Outcome Measures, Olfactory Dysfunction Prevalence and the Impact of Management—A Systematic Review and Meta‐Analysis

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Olfactory dysfunction (OD) is an increasingly recognized but under‐investigated comorbidity of cystic fibrosis (CF). Its prevalence, assessment methods, and response to CF‐directed treatment, including highly effective modulator therapy (HEMT) remains incompletely characterized.
Luca Cox, Kofi Cox, Katherine Whitcroft, Susanne Weise, Sonal Kansra, Eishaan Bhargava   +5 more
wiley   +1 more source

Low-Dose Azithromycin Attenuates OVA-Induced Airway Remodeling and Inflammation via Down-Regulating TGF-βl Expression in RAT

European Journal of Inflammation, 2013
Asthma is characteristic with chronic airway inflammation and remodeling. Azithromycin (AZM), the 15-member macrolide, is known to present an anti-inflammatory effect and is increasingly being used in the treatment of chronic inflammatory pulmonary ...
L. Wan, L. Liu, Z. Zhang, Y. Zhou, Y. Xiong, D. Li, L. Zhou   +6 more
doaj   +1 more source

Assessing the Mucosal Inflammatory Endotype of Obesity in Chronic Rhinosinusitis

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis (CRS) is a heterogeneous inflammatory syndrome of the paranasal sinuses that is defined phenotypically as either with nasal polyps (CRSwNP) or without nasal polyps (CRSsNP). More recently, inflammatory markers have been used to cluster patients into putative endotypes that are presumed to have a common ...
Jeffanie W. Gayoso, Li‐Ching Huang, Quanhu Sheng, Daniel Lofgren, Ping Li, Katherine Cahill, Mason Krysinski, Rakesh K. Chandra, Justin H. Turner, Naweed Chowdhury   +9 more
wiley   +1 more source

Effect of aging on airway remodeling and muscarinic receptors in a murine acute asthma model

, 2013
Ji Young Kang, Sook Young Lee, Chin Kook Rhee, Seung Joon Kim, Soon Seog Kwon, Young Kyoon KimDepartment of Internal Medicine, College of Medicine, Catholic University of Korea, Seoul, KoreaBackground and objectives: The influence of aging on the ...
Lee SY, Kang JY, Rhee CK, Kim YK, Kwon SS, Kim SJ   +5 more
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