Results 61 to 70 of about 45,718 (290)

ORMDL3 Transgenic Mice Have Increased Airway Remodeling and Airway Responsiveness Characteristic of Asthma [PDF]

, 2014
Orosomucoid-like (ORMDL)3 has been strongly linked with asthma in genetic association studies. Because allergen challenge induces lung ORMDL3 expression in wild-type mice, we have generated human ORMDL3 zona pellucida 3 Cre (hORMDL3(zp3-Cre)) mice that ...
Suzukawa, Maho, Niwa, Maho, McGeough, Matthew D, Beppu, Andrew, Hoffman, Hal M, Pena, Carla A, Tam, Arvin B, Rosenthal, Peter, Mueller, James L, Doherty, Taylor A, Broide, David H, Miller, Marina   +11 more
core   +1 more source

Pathway reconstruction of airway remodeling in chronic lung diseases: a systems biology approach. [PDF]

PLoS ONE, 2014
Airway remodeling is a pathophysiologic process at the clinical, cellular, and molecular level relating to chronic obstructive airway diseases such as chronic obstructive pulmonary disease (COPD), asthma and mustard lung.
Ali Najafi, Ali Najafi, Ali Masoudi-Nejad, Mostafa Ghanei, Mohamad-Reza Nourani, Ali Moeini   +5 more
doaj   +1 more source

The KIF6‐RBP Complex Orchestrates mRNA Transport Required for Sperm Flagellar Assembly

Advanced Science, EarlyView.
Two homozygous deleterious KIF6 variants are identified in unrelated men with impaired sperm motility. Mouse models and multi‐omics analyses reveal that KIF6 cooperates with the RNA‐binding proteins FMRP and FXR1 to deliver mRNAs essential for sperm flagellar assembly, linking disrupted mRNA transport to reduced abundance of key structural and ...
Chunbo Xie, Sibing Yi, Xinle Lin, Shen Zhang, Weili Wang, Shimin Yuan, Lanlan Meng, Yong Li, Chen Tan, Chunjia Wei, Yanyan Yu, Yaoqiong Liang, Huan Zhang, Liang Hu, Guangxiu Lu, Wenbin He, Qianjun Zhang, Juan Du, Ge Lin, Chaofeng Tu, Yue‐Qiu Tan   +20 more
wiley   +1 more source

S100A8/A9‐High Macrophages Activate Intestinal Fibroblasts via mCCL6/hCCL15‐CCR1 Axis to Drive Intestinal Fibrosis in Crohn's Disease

Advanced Science, EarlyView.
S100A8/A9‐high macrophages are markedly enriched in the stenotic intestinal tissue of patients with Crohn's disease. These profibrotic macrophages secrete mCCL6 in a STAT3‐dependent manner. mCCL6 and its human ortholog hCCL15 activate fibroblasts via the CCR1 receptor, thereby driving excessive collagen deposition.
Shu Wang, Jiayun Wang, Junjie Lin, Ziping Ye, Geyujia Zhou, Jingjing Ma, Junjian Sun, Jiang Yu, Yingdi Zhang, Nana Tang, Chunhua Jiao, Xiaojing Zhao, Hongjie Zhang   +12 more
wiley   +1 more source

Severe pediatric asthma with a poor response to omalizumab: a report of three cases and three-dimensional bronchial wall analysis

Journal of International Medical Research, 2022
Omalizumab is used for the treatment of persistent severe allergic asthma in adults and children. However, some patients remain symptomatic even after omalizumab treatment. In bronchial asthma, chronic inflammation of the bronchial wall causes thickening
Mitsuru Tsuge, Masanori Ikeda, Yoichi Kondo, Hirokazu Tsukahara   +3 more
doaj   +1 more source

Mechanisms of Remodeling in Asthmatic Airways [PDF]

Journal of Allergy, 2012
Asthma is a chronic inflammatory airway disorder characterized by airway hyperresponsiveness and reversible airflow obstruction. Subgroups of asthma patients develop airflow obstruction that is irreversible or only partially reversible and experience an accelerated rate of lung function decline.
Adrian Shifren, Chad Witt, Chandrika Christie, Mario Castro   +3 more
openaire   +3 more sources

Genes and Pathways Regulating Decline in Lung Function and Airway Remodeling in Asthma [PDF]

, 2019
Asthma is a common disorder of the airways characterized by airway inflammation and by decline in lung function and airway remodeling in a subset of asthmatics.
Hur, Gyu Young, Broide, David H
core   +1 more source

Budesonide and Calcitriol Synergistically Inhibit Airway Remodeling in Asthmatic Mice

, 2018
Background and Objective. While calcitriol can inhibit airway remodeling in asthmatic mice, the mechanism remains unclear. The purpose of this study was to explore the mechanism of action of calcitriol on airway remodeling in asthma and its interaction ...
Zhiwei Yu, Jun Qian, Yaqin Xu
core   +2 more sources

Bacillus Calmette-Guerin alleviates airway inflammation and remodeling by preventing TGF-β1 induced epithelial–mesenchymal transition

Human Vaccines & Immunotherapeutics, 2017
Bacillus Calmette-Guerin (BCG) is a potent agent for the prevention of tuberculosis. Current studies have regarded BCG as an immunomodulator. However, there is little information on whether it can be used to inhibit airway inflammation and airway ...
Xinrui Tian, Xinli Tian, Rujie Huo, Qin Chang, Guoping Zheng, Yan Du, Yan Chen, Bo Niu   +7 more
doaj   +1 more source

Airway wall remodelling in asthma [PDF]

Thorax, 1997
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A E, Redington, P H, Howarth
openaire   +2 more sources