Results 61 to 70 of about 397,469 (244)
Epithelial SIRT6 governs IL-17A pathogenicity and drives allergic airway inflammation and remodeling
Nature Communications, 2023 Dysregulation of IL-17A is closely associated with airway inflammation and remodeling in severe asthma. However, the molecular mechanisms by which IL-17A is regulated remain unclear.
Jingyun Quan +19 more
doaj +1 more source
Advanced Science, EarlyView.Sepsis‑induced pediatric acute respiratory distress syndrome suppresses FOXF1 in lung endothelial cells which causes life‐threatening lung damage. To counter this, researchers developed nanoparticles that specifically target these cells and deliver FOXF1 mRNA.
Zicheng Deng +14 more
wiley +1 more source
Pathway reconstruction of airway remodeling in chronic lung diseases: a systems biology approach. [PDF]
PLoS ONE, 2014 Airway remodeling is a pathophysiologic process at the clinical, cellular, and molecular level relating to chronic obstructive airway diseases such as chronic obstructive pulmonary disease (COPD), asthma and mustard lung.
Ali Najafi +5 more
doaj +1 more source
Advanced Science, EarlyView.After IAV infection, NS1 induces PARP1 phase transition, reducing molecular mobility in condensates, prolonging host transcriptional pause, aiding RdRp cap snatching, and promoting viral transcription. ABSTRACT Influenza A virus (IAV) commandeers host transcriptional machinery to replicate, but mechanisms remain elusive.
Shufeng Ma +12 more
wiley +1 more source
A Robust Bio‐Supportive Hydrogel Patch for Full‐Thickness Repair of Gastroesophageal Defects
Advanced Science, EarlyView.Gastroesophageal defect repair remains a formidable clinical challenge plagued by high leakage and life‐threatening complications. We develop a double‐disc, highly crystalline PVA‐based RBS hydrogel patch featuring suture‐free sealing, robust acid/enzyme resistance and mechanical durability.
Xingqi Song +13 more
wiley +1 more source
Curvature‐Directed Elongation and Chiral Tilting Drive Asymmetric Tissue Patterning
Advanced Science, EarlyView.Curvature and cell handedness together break tissue symmetry. On convex and concave surfaces, cells elongate along opposite geometric axes and tilt in a consistent chirality‐driven direction, yielding opposite alignment patterns from the same cells. Reversing intrinsic cell chirality reverses both.
Liyao Xu +6 more
wiley +1 more source
Inhibition of Orai-STIM coupling alleviates experimentally-induced airways remodeling changes
Revista Alergia México, 2018 Background: In asthma, airway remodeling changes contribute to thickening of airway walls and, consequently, lead to poor clinical outcomes among asthmatic patients.
Martina Sutovska, Sona Franova
doaj
Human Vaccines & Immunotherapeutics, 2017 Bacillus Calmette-Guerin (BCG) is a potent agent for the prevention of tuberculosis. Current studies have regarded BCG as an immunomodulator. However, there is little information on whether it can be used to inhibit airway inflammation and airway ...
Xinrui Tian +7 more
doaj +1 more source
Journal of International Medical Research, 2022 Omalizumab is used for the treatment of persistent severe allergic asthma in adults and children. However, some patients remain symptomatic even after omalizumab treatment. In bronchial asthma, chronic inflammation of the bronchial wall causes thickening
Mitsuru Tsuge +3 more
doaj +1 more source
Temporal Assessment Of Airway Remodeling In Severe Asthma Using Quantitative Computed Tomography
, 2015 Temporal Assessment Of Airway Remodeling In Severe Asthma Using Quantitative Computed ...
Vimal Raj (7628951) +13 more
core +6 more sources