Results 41 to 50 of about 45,718 (290)

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Complete Dependence on CD4+ Cells in Late Asthmatic Response, but Limited Contribution of the Cells to Airway Remodeling in Sensitized Mice

Journal of Pharmacological Sciences, 2011
.: It is known that the late asthmatic response (LAR), a characteristic feature of asthma, is closely associated with CD4+ Th2 cell–mediated allergic inflammation. Airway remodeling is also a pathogenesis of asthma, but literature reporting roles of CD4+
Takeshi Nabe, Toyoko Morishita, Kouki Matsuya, Ayumu Ikedo, Masanori Fujii, Nobuaki Mizutani, Shin Yoshino   +6 more
doaj   +1 more source

iTRAQ-Based Proteomics Reveals Gu-Ben-Fang-Xiao Decoction Alleviates Airway Remodeling via Reducing Extracellular Matrix Deposition in a Murine Model of Chronic Remission Asthma

Frontiers in Pharmacology, 2021
Airway remodeling is a primary pathological feature of asthma. The current therapy for asthma mainly targets reducing inflammation but not particularly airway remodeling.
Qiongqiong Xing, Qiongqiong Xing, Qiongqiong Xing, Yannan You, Yannan You, Yannan You, Xia Zhao, Xia Zhao, Xia Zhao, Jianjian Ji, Jianjian Ji, Hua Yan, Hua Yan, Hua Yan, Yingmei Dong, Yingmei Dong, Yingmei Dong, Lishun Ren, Lishun Ren, Lishun Ren, Yuanyuan Ding, Yuanyuan Ding, Yuanyuan Ding, Shuting Hou, Shuting Hou, Shuting Hou   +25 more
doaj   +1 more source

Interstitium‐Mimicking Porous Alveolar Membranes Enable Physiologic Aerosol Transport and Distinct Acute‐Chronic Lung Injury Responses

Advanced Functional Materials, EarlyView.
An interstitium‐mimicking membrane combines three‐dimensional alveolar geometry, high pore interconnectivity, and mechanical compliance to overcome transport limitations of conventional lung‐on‐chip barriers. The resulting platform supports physiologic aerosol transport, quantitative analysis of cross‐barrier particle movement, and reveals divergent ...
Jae‐Won Choi, Sheng Zhang, Abbas Jalili, August Kohls, Woo‐Youl Maeng, Sikandar Azam, Wu Liu, Barbie Varghese, Yixin Zhao, Xi Ren, Shimin Liu, Si‐Yang Zheng   +11 more
wiley   +1 more source

A Novel Decellularized Fibrocartilage Graft Promotes Tympanic Membrane Repair

Advanced Healthcare Materials, EarlyView.
An off‐the‐shelf decellularized porcine meniscus fibrocartilage graft (MEND) is engineered for pediatric tympanoplasty. Featuring a microchannel architecture that promotes host cell invasion, MEND rapidly closes tympanic membrane perforations and fully remodels in vivo, outperforming fascia and matching cartilage grafts while avoiding donor‐site ...
Paul M. Gehret, Ryan M. Friedman, Gautham Nair, Stephanie L. Fung, Dana D. Ragbirsingh, John Germiller, Riccardo Gottardi   +6 more
wiley   +1 more source

Epithelial-Mesenchymal Transition in Asthma Airway Remodeling Is Regulated by the IL-33/CD146 Axis

Frontiers in Immunology, 2020
Epithelial-mesenchymal transition (EMT) is essential in asthma airway remodeling. IL-33 from epithelial cells is involved in pulmonary fibrosis. CD146 has been extensively explored in cancer-associated EMT.
Zhixiao Sun, Ningfei Ji, Qiyun Ma, Ranran Zhu, Zhongqi Chen, Zhengxia Wang, Yan Qian, Chaojie Wu, Fan Hu, Mao Huang, Mingshun Zhang   +10 more
doaj   +1 more source

Pathological airway remodelling in inflammation [PDF]

The Clinical Respiratory Journal, 2010
AbstractIntroduction:  Airway remodelling refers to a wide pattern of patophysiological mechanisms involving smooth muscle cell hyperplasia, increase of activated fibroblasts and myofibroblasts with deposition of extracellular matrix. In asthma, it includes alterations of the epithelial cell layer with goblet cell hyperplasia, thickening of basement ...
Gunilla, Westergren-Thorsson, Kristoffer, Larsen, Kristian, Nihlberg, Annika, Andersson-Sjöland, Oskar, Hallgren, György, Marko-Varga, Leif, Bjermer   +6 more
openaire   +2 more sources

Cellular Responses to Mechanical Cues Across Scales: From Fundamental Insights to Translational Potential

Advanced Healthcare Materials, EarlyView.
This review examines how cellular behavior is regulated by mechanical cues transmitted through soft biomaterials, from single‐cell mechanosensing to tissue‐level adaptation. It highlights why physiological relevance, rather than model complexity alone, is critical for translational mechanobiology and introduces a scoring framework linking material ...
Mathias Polz, Manuel P. Kainz, Niklas Haider, Theresa Rienmüller, Kerstin Lenk, Rupert Kargl, Michele Terzano, Gerhard Sommer, Gerhard A. Holzapfel, Julia Fuchs   +9 more
wiley   +1 more source

Effect of Selective Cysteinyl Leukotriene Receptor Antagonists on Airway Inflammation and Matrix Metalloproteinase Expression in a Mouse Asthma Model

Pediatrics and Neonatology, 2012
Cysteinyl leukotrienes (CysLTs) play a major role in the pathogenic changes of airway inflammation in asthma treatment. The matrix metalloproteinase (MMP) family, especially MMP-9 and MMP-2 levels, can reflect the status of airway remodeling.
Chia-Hsiu Hsu, Chun-Ming Hu, Ko-Hsiu Lu, Shun-Fa Yang, Chung-Hung Tsai, Chun-Liang Ko, Hai-Lun Sun, Ko-Huang Lue   +7 more
doaj   +1 more source

Perivascular Matrix Densification Dysregulates Angiogenesis and Activates Pro‐Inflammatory Endothelial Cells

Advanced Science, EarlyView.
Perivascular matrix densification promotes the emergence of aberrant endothelial tip cells (ATECs) that invade and persist within fibrotic microenvironments. Using in vivo lineage tracing and a human microvessel model, this study shows that fibrous matrix cues destabilize VE‐cadherin–mediated junctions to gate TGF‐β signaling, inducing a pro ...
Jingyi Xia, William Y. Wang, Kyle A. Jacobs, Kairav Maniar, Daphne Lin, Evan H. Jarman, Daniel L. Matera, Kristen Loesel, Christopher D. Davidson, Harrison L. Hiraki, Xiaotian Tan, Eve H. Shikanov, Robert N. Kent, Carole Parent, Xudong Fan, Ariella Shikanov, Matthew L. Kutys, Brendon M. Baker   +17 more
wiley   +1 more source