Results 31 to 40 of about 365,854 (289)

Can HRCT be used as a marker of airway remodelling in children with difficult asthma? [PDF]

, 2006
BACKGROUND: Whole airway wall thickening on high resolution computed tomography (HRCT) is reported to parallel thickening of the bronchial epithelial reticular basement membrane (RBM) in adult asthmatics. A similar relationship in children with difficult
Khoo L, Khoo, L, Payne, DN, Hansell DM, Bush, A, Saglani S, Saglani, S, Ujita, M, Jeffery, PK, Papaioannou G, Jeffery PK, Bush A, Papaioannou, G, Owens, C, Hansell, DM, Owens C, Payne DN, Owens, CM, Ujita M   +18 more
core   +1 more source

Urinary CC16 after challenge with dry air hyperpnoea and mannitol in recreational summer athletes [PDF]

, 2013
Airway epithelial injury is regarded as a key contributing factor to the pathogenesis of exercise-induced bronchoconstriction (EIB) in athletes. The concentration of the pneumoprotein club cell (Clara cell) CC16 in urine has been found to be a non ...
Pascale Kippelen, Leena Ali, Ali, Leena, Anderson, Sandra D., Bjermer, Leif, Tufvesson, E, Bjermer, L, Tufvesson, Ellen, Ali, L, Kippelen, P, Kippelen, Pascale, Leif Bjermer, Sandra D. Anderson, Anderson, SD, Ellen Tufvesson   +14 more
core   +1 more source

The Endogenous Th17 Response in NO2-Promoted Allergic Airway Disease Is Dispensable for Airway Hyperresponsiveness and Distinct from Th17 Adoptive Transfer [PDF]

, 2013
Severe, glucocorticoid-resistant asthma comprises 5-7% of patients with asthma. IL-17 is a biomarker of severe asthma, and the adoptive transfer of Th17 cells in mice is sufficient to induce glucocorticoid-resistant allergic airway disease.
Suratt, Benjamin T., Weiss Daniel J., Laura Hoyt, Daggett, Rebecca, Alcorn John F., Poynter, ME, Daggett, R, Daggett Rebecca, Martin, Rebecca A., Lundblad Lennart K. A., Martin, RA, Daniel J. Weiss (460686), Ather Jennifer L., Lennart K. A. Lundblad (49082), Jennifer L. Ather (460682), Rebecca Daggett (460683), Alcorn, John F., Poynter, Matthew E., Hoyt Laura, Laura Hoyt (460684), John F. Alcorn (298001), Hoyt, L, Martin Rebecca A., Lennart K A Lundblad, Rebecca A Martin, Lundblad, Lennart K. A., Rebecca A. Martin (435571), Hoyt, Laura, Weiss, Daniel J., Poynter Matthew E., Rebecca Daggett, John F Alcorn, Alcorn, JF, Benjamin T Suratt, Suratt, BT, Ather, Jennifer L., Daniel J Weiss, Matthew E. Poynter (435575), Weiss, DJ, Lundblad, LKA, Jennifer L Ather, Benjamin T. Suratt (460685), Ather, JL, Chu, Hong Wei, Matthew E Poynter, Suratt Benjamin T.   +45 more
core   +2 more sources

Respiratory Microbiota Profiles Associated With the Progression From Airway Inflammation to Remodeling in Mice With OVA-Induced Asthma

Frontiers in Microbiology, 2021
BackgroundThe dysbiosis of respiratory microbiota plays an important role in asthma development. However, there is limited information on the changes in the respiratory microbiota and how these affect the host during the progression from acute allergic ...
Jun Zheng, Qian Wu, Ya Zou, Meifen Wang, Li He, Sheng Guo   +5 more
doaj   +1 more source

Effect of corticosteroids and long-acting ß2- agonists in a human cell culture based "in vitro" model of airway inflammation and tissue remodeling [PDF]

, 2006
Asthma and chronic obstructive pulmonary disease (COPD) are characterized by chronic airway inflammation and remodeling. In non-pathological conditions tissue homeostasis is maintained by the balance between extracellular matrix (ECM) synthesis and ...
Goulet, Stéphanie
core   +1 more source

Analysis of Differentially Expressed MicroRNAs in OVA-induced Airway Remodeling Model Mice

Iranian Journal of Allergy, Asthma and Immunology, 2022
MicroRNAs (miRNAs) can participate in airway remodeling by regulating immune molecule expression. Here, we aimed to identify the differential miRNAs involved in airway remodeling. Airway remodeling was induced by ovalbumin in female BALB/C mice.
Chang Xu, Yilan Song, Chongyang Wang, Jingzhi Jiang, Zhiguang Wang, Liangchang Li, Guanghai Yan   +6 more
doaj   +1 more source

Clinical relevance of airway remodelling in airway diseases [PDF]

European Respiratory Journal, 2007
Asthma and chronic obstructive pulmonary disease (COPD) are characterised by airflow obstruction, airway remodelling (measurable structural change) and inflammation. The present review will examine the relationship between airway remodelling in these two conditions with respect to symptoms, abnormal lung function, airway hyperresponsiveness and decline
A L, James, S, Wenzel
openaire   +2 more sources

Pathobiology of Airway Remodeling in Asthma: The Emerging Role of Integrins

Journal of Asthma and Allergy, 2022
Chitra Joseph, Amanda L Tatler Centre for Respiratory Research, National Institute for Health Research Biomedical Research Centre, School of Medicine, University of Nottingham, Nottingham, UKCorrespondence: Amanda L Tatler, Centre for Respiratory ...
Joseph C, Tatler AL
doaj  

Aldose reductase inhibition prevents allergic airway remodeling through PI3K/AKT/GSK3β pathway in mice. [PDF]

PLoS ONE, 2013
Long-term and unresolved airway inflammation and airway remodeling, characteristic features of chronic asthma, if not treated could lead to permanent structural changes in the airways.
Umesh C S Yadav, Amarjit S Naura, Leopoldo Aguilera-Aguirre, Istvan Boldogh, Hamid A Boulares, William J Calhoun, Kota V Ramana, Satish K Srivastava   +7 more
doaj   +1 more source

Role of Abl in airway hyperresponsiveness and airway remodeling [PDF]

Respiratory Research, 2013
Asthma is a chronic disease that is characterized by airway hyperresponsiveness and airway remodeling. The underlying mechanisms that mediate the pathological processes are not fully understood. Abl is a non-receptor protein tyrosine kinase that has a role in the regulation of smooth muscle contraction and smooth muscle cell proliferation in vitro. The
Cleary, Rachel A, Wang, Ruping, Wang, Tao, Tang, Dale D   +3 more
openaire   +2 more sources