Results 21 to 30 of about 397,469 (244)

Novel Lung Growth Strategy with Biological Therapy Targeting Airway Remodeling in Childhood Bronchial Asthma

Children, 2022
Anti-inflammatory therapy, centered on inhaled steroids, suppresses airway inflammation in asthma, reduces asthma mortality and hospitalization rates, and achieves clinical remission in many pediatric patients.
Mitsuru Tsuge, Masanori Ikeda, Hirokazu Tsukahara   +2 more
doaj   +1 more source

Salidroside Ameliorated Intermittent Hypoxia-Aggravated Endothelial Barrier Disruption and Atherosclerosis via the cAMP/PKA/RhoA Signaling Pathway

Frontiers in Pharmacology, 2021
Background: Endothelial barrier dysfunction plays a key role in atherosclerosis progression. The primary pathology of obstructive sleep apnea-hypopnea syndrome is chronic intermittent hypoxia (IH), which induces reactive oxygen species (ROS ...
Linyi Li, Linyi Li, Linyi Li, Yunyun Yang, Yunyun Yang, Yunyun Yang, Huina Zhang, Huina Zhang, Huina Zhang, Yunhui Du, Yunhui Du, Yunhui Du, Xiaolu Jiao, Xiaolu Jiao, Xiaolu Jiao, Huahui Yu, Huahui Yu, Huahui Yu, Yu Wang, Yu Wang, Yu Wang, Qianwen Lv, Qianwen Lv, Qianwen Lv, Fan Li, Fan Li, Fan Li, Qiuju Sun, Qiuju Sun, Qiuju Sun, Yanwen Qin, Yanwen Qin, Yanwen Qin   +32 more
doaj   +1 more source

Hedgehog interacting protein (HHIP) represses airway remodeling and metabolic reprogramming in COPD-derived airway smooth muscle cells

, 2021
Although HHIP locus has been consistently associated with the susceptibility to COPD including airway remodeling and emphysema in genome-wide association studies, the molecular mechanism underlying this genetic association remains incompletely understood.
Xu, S., Pham, B., Zhang, L., Polverino, F., Hao, Y., Lao, T., Owen, C.A., Li, Y., Guo, F., Li, L., Zhou, X., Caroline A. Owen, Betty Pham, Shuang Xu, Lijia Li, Li Zhang, Feng Guo, Xiaobo Zhou, Taotao Lao, Francesca Polverino, Yuan Hao, Yan Li   +21 more
core   +1 more source

Airway wall remodeling in asthma : novel mechanisms of human bronchial smooth muscle cells in the induction of angiogenesis [PDF]

, 2014
Asthma is a global major health concern and it affects estimated 300 million people. The prevalence of asthma is rising and there is no cure for asthma, only the symptoms can be controlled.
Keglowich, Laura Franziska
core   +1 more source

Correlation between sestrin2 expression and airway remodeling in COPD

BMC Pulmonary Medicine, 2020
Background Airway remodeling is a major pathological characteristic of chronic obstructive pulmonary disease (COPD), and has been shown to be associated with oxidative stress.
Da-Wei Zhang, Yuan-Yuan Wei, Shuang Ji, Guang-He Fei   +3 more
doaj   +1 more source

Airway remodeling in asthma:Visualization and treatment of structural airway wall changes associated with severe asthma [PDF]

The thesis “Airway Remodeling in Asthma - Visualization and Treatment of Structural Airway Wall Changes Associated with Severe Asthma” primarily investigates the impact of bronchial thermoplasty (BT), a treatment for severe asthma on airway remodeling ...
Wijsman, P.C.
core   +7 more sources

Can HRCT be used as a marker of airway remodelling in children with difficult asthma? [PDF]

, 2006
BACKGROUND: Whole airway wall thickening on high resolution computed tomography (HRCT) is reported to parallel thickening of the bronchial epithelial reticular basement membrane (RBM) in adult asthmatics. A similar relationship in children with difficult
Khoo L, Khoo, L, Payne, DN, Hansell DM, Bush, A, Saglani S, Saglani, S, Ujita, M, Jeffery, PK, Papaioannou G, Jeffery PK, Bush A, Papaioannou, G, Owens, C, Hansell, DM, Owens C, Payne DN, Owens, CM, Ujita M   +18 more
core   +1 more source

Quantification of collagen and proteoglycan deposition in a murine model of airway remodelling [PDF]

, 2005
Background: Sub- epithelial extracellular matrix deposition is a feature of asthmatic airway remodelling associated with severity of disease, decline in lung function and airway hyperresponsiveness.
Reinhardt Alistair K, Robin J McAnulty, Reinhardt, AK, McAnulty Robin J, Geoffrey J Laurent, Laurent, GJ, Laurent Geoffrey J, Bottoms, SE, Bottoms Stephen E, McAnulty, RJ, Stephen E Bottoms, Alistair K Reinhardt   +11 more
core   +2 more sources

IFN-γ and TNF-α synergize to inhibit CTGF expression in human lung endothelial cells. [PDF]

, 2012
Connective tissue growth factor (CTGF/CCN2) is an angiogenetic and profibrotic factor, acting downstream of TGF-β, involved in both airway- and vascular remodeling.
Steffen Kunzmann, Roderich Laug, Laug, Roderich, Norbert Schütze, Krump-Konvalinkova, Vera, Boris W Kramer, Vera Krump-Konvalinkova, Kramer, Boris W., Markus Fehrholz, Schütze, Norbert, Kunzmann, Steffen, Schuetze, Norbert, Fehrholz, Markus, Speer, Christian P., Christian P Speer, Laug Roderich, Kunzmann Steffen, Krump-Konvalinkova Vera, Speer Christian P., Fehrholz Markus, Schütze Norbert, Kramer Boris W.   +21 more
core   +2 more sources

Respiratory Microbiota Profiles Associated With the Progression From Airway Inflammation to Remodeling in Mice With OVA-Induced Asthma

Frontiers in Microbiology, 2021
BackgroundThe dysbiosis of respiratory microbiota plays an important role in asthma development. However, there is limited information on the changes in the respiratory microbiota and how these affect the host during the progression from acute allergic ...
Jun Zheng, Qian Wu, Ya Zou, Meifen Wang, Li He, Sheng Guo   +5 more
doaj   +1 more source