Results 81 to 90 of about 3,403,950 (370)

PRMT1 Ablation in Endothelial Cells Causes Endothelial Dysfunction and Aggravates COPD Attributable to Dysregulated NF‐κB Signaling

open access: yesAdvanced Science, EarlyView.
This study investigates the role of protein arginine methyltransferase 1 (PRMT1) in endothelial cells (ECs) in chronic obstructive pulmonary disease (COPD). Mice with endothelial‐specific PRMT1 deletion develop pulmonary hemorrhage, inflammation, and apoptosis, driven by excessive nuclear factor kappa B activation.
Thi Thuy Vy Tran   +7 more
wiley   +1 more source

Modelling Airway Geometry as Stock Market Data using Bayesian Changepoint Detection [PDF]

open access: yesIn Lecture Notes in Computer Science, vol 11861. (2019) Springer, Cham, 2019
Numerous lung diseases, such as idiopathic pulmonary fibrosis (IPF), exhibit dilation of the airways. Accurate measurement of dilatation enables assessment of the progression of disease. Unfortunately the combination of image noise and airway bifurcations causes high variability in the profiles of cross-sectional areas, rendering the identification of ...
arxiv   +1 more source

Histone Deacetylase 6 (HDAC6) in Ciliopathies: Emerging Insights and Therapeutic Implications

open access: yesAdvanced Science, EarlyView.
HDAC6 regulates primary cilia, crucial for cellular signalling and environmental responses. Dysregulation of HDAC6 contributes to ciliopathies, affecting multiple organs. This review examines HDAC6's role in ciliogenesis, its interaction with signaling molecules, and its potential as a therapeutic target.
Zhiyi Wang   +5 more
wiley   +1 more source

Positive correlation of airway resistance and serum asymmetric dimethylarginine level in COPD patients with systemic markers of low-grade inflammation

open access: yesInternational Journal of COPD, 2017
Gabor Tajti,1,2 Rudolf Gesztelyi,3 Krisztian Pak,3 Csaba Papp,1 Sandor Keki,4 Magdolna Emma Szilasi,2 Angela Mikaczo,2 Andrea Fodor,2 Maria Szilasi,2 Judit Zsuga1 1Department of Health Systems Management and Quality Management for Health Care, Faculty ...
Tajti G   +9 more
doaj  

Effects of propofol, desflurane, and sevoflurane on respiratory functions following endoscopic endonasal transsphenoidal pituitary surgery: a prospective randomized study [PDF]

open access: yesKorean Journal of Anesthesiology, 2019
Background General anesthesia with intravenous or inhalation anesthetics reduces respiratory functions. We investigated the effects of propofol, desflurane, and sevoflurane on postoperative respiratory function tests.
Abdulvahap Oguz   +4 more
doaj   +1 more source

Structure and position-aware graph neural network for airway labeling [PDF]

open access: yesarXiv, 2022
We present a novel graph-based approach for labeling the anatomical branches of a given airway tree segmentation. The proposed method formulates airway labeling as a branch classification problem in the airway tree graph, where branch features are extracted using convolutional neural networks (CNN) and enriched using graph neural networks.
arxiv  

Optimisation of growth conditions for ovine airway epithelial cell differentiation at an air-liquid interface [PDF]

open access: yes, 2018
Respiratory tract infections are of significant concern in the agriculture industry. There is a requirement for the development of well-characterised in vitro epithelial cell culture models in order to dissect the diverse molecular interactions occurring
Berry, Catherine C.   +3 more
core   +2 more sources

Targeting Senescence with Apigenin Improves Chemotherapeutic Efficacy and Ameliorates Age‐Related Conditions in Mice

open access: yesAdvanced Science, EarlyView.
As a plant‐derived flavonoid, apigenin directly targets PRDX6 to inhibit its PLA2 activity, blocking HSPA8 activation and disturbing its interactions with ATM and p38MAPK in senescent cells. By dampening wide spectrum expression of the SASP, apigenin prevents loss of tissue homeostasis, improves organ function, and alleviates multiple age‐related ...
Hongwei Zhang   +10 more
wiley   +1 more source

The Effects of the Position Changes of Critical Care Patients on Respiratory and Cardiac Parameters

open access: yesTürk Yoğun Bakim Derneği Dergisi, 2021
Objective:Position changes in patients requiring critical care aimed to mobilise secretions, prevent compression wounds and decrease the risk of ventilator-related pneumonia.
İsa Kılıç   +3 more
doaj   +1 more source

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