Results 271 to 280 of about 532,309 (312)
Leonurine-Standardized <i>Leonurus japonicus</i> Extract Promotes Recovery from Immobilization-Induced Muscle Atrophy via PI3K/Akt/mTOR Signaling in Mice. [PDF]
J Microbiol BiotechnolLee J +5 more
europepmc +1 more source
Emerging agents that target signaling pathways in cancer fibroblast cells (Review). [PDF]
Int J OncolWan Y, Liu XQ, Liu D, Li KD, Zhang DD.
europepmc +1 more source
Modulation of the PI3K/Akt signaling pathway by steroidal saponins: therapeutic implications in cancer. [PDF]
Front PharmacolMajnooni MB +8 more
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Science Signaling, 2012
ATP and ADP regulate a conformational switch that determines the kinase activity of Akt.
Sean J, Humphrey, David E, James
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ATP and ADP regulate a conformational switch that determines the kinase activity of Akt.
Sean J, Humphrey, David E, James
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2018
AKT is a serine/threonine kinase member of the AGC family of protein kinases. The three isoforms of AKT (AKT1/2/3) play a central role in growth, proliferation, glucose uptake, metabolism, protein translation and cell survival. Given the importance of the AKT pathway in all these processes it is not surprising that its deregulation is associated with a
openaire +3 more sources
AKT is a serine/threonine kinase member of the AGC family of protein kinases. The three isoforms of AKT (AKT1/2/3) play a central role in growth, proliferation, glucose uptake, metabolism, protein translation and cell survival. Given the importance of the AKT pathway in all these processes it is not surprising that its deregulation is associated with a
openaire +3 more sources
2000
An increasing number of publications have underscored the importance of the serine/threonine kinase Akt in the regulation of cell survival, proliferation, and insulin-dependent metabolic cell responses. Critical to the understanding of Akt signaling in cells are experimental methods that assess its activation and phosphorylation state. In this chapter,
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An increasing number of publications have underscored the importance of the serine/threonine kinase Akt in the regulation of cell survival, proliferation, and insulin-dependent metabolic cell responses. Critical to the understanding of Akt signaling in cells are experimental methods that assess its activation and phosphorylation state. In this chapter,
openaire +2 more sources
Science Signaling, 2009
PKCα is an essential component of a pathway linking EGFR signaling to mTOR and cell proliferation in glioblastoma.
Peter K, Vogt, Jonathan R, Hart
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PKCα is an essential component of a pathway linking EGFR signaling to mTOR and cell proliferation in glioblastoma.
Peter K, Vogt, Jonathan R, Hart
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Current Topics in Medicinal Chemistry, 2020
Cancer is a devastating disease that has plagued humans from ancient times to this day. After decades of slow research progress, promising drug development, and the identification of new targets, the war on cancer was launched, in 1972. The P13K/Akt pathway is a growth-regulating cellular signaling pathway, which in many human cancers is over ...
Nne E, Uko +3 more
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Cancer is a devastating disease that has plagued humans from ancient times to this day. After decades of slow research progress, promising drug development, and the identification of new targets, the war on cancer was launched, in 1972. The P13K/Akt pathway is a growth-regulating cellular signaling pathway, which in many human cancers is over ...
Nne E, Uko +3 more
openaire +2 more sources
Journal of Clinical Oncology, 2004
The protein kinase Akt is activated in a wide variety of cancers, and this activation results in enhanced resistance to apoptosis through multiple mechanisms. This article reviews the control of Akt activation by the opposing actions of the oncogene phosphoinositide 3-kinase (PI3-K) and the tumor suppressor phosphatase and tensin homolog deleted on ...
James E, Thompson, Craig B, Thompson
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The protein kinase Akt is activated in a wide variety of cancers, and this activation results in enhanced resistance to apoptosis through multiple mechanisms. This article reviews the control of Akt activation by the opposing actions of the oncogene phosphoinositide 3-kinase (PI3-K) and the tumor suppressor phosphatase and tensin homolog deleted on ...
James E, Thompson, Craig B, Thompson
openaire +2 more sources