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Tumor-Agnostic AKT Inhibition: Is It Time to AKT?
Clinical Cancer ResearchSummary Basket trials of AKT-mutated tumors show that pan-AKT inhibitors are active in hormone receptor–positive breast cancer. There is mounting evidence for AKT inhibition in other tumor types, although small sample sizes limit evaluation of the tumor-agnostic potential for AKT inhibition.
Ricardo Dahmer Tiecher, Alison M. Schram
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Science Signaling, 2013
Deubiquitination limits the kinase activity of Akt in the absence of growth factor stimulation.
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Deubiquitination limits the kinase activity of Akt in the absence of growth factor stimulation.
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Knidia oder: Des Aktes erster Akt
2016kritische berichte - Zeitschrift für Kunst- und Kulturwissenschaften, Bd. 17 Nr.
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AKT and the Hallmarks of Cancer
Cancer ResearchAbstract Nearly a quarter century ago, Hanahan and Weinberg conceived six unifying principles explaining how normal cells transform into malignant tumors. Their provisional set of biological capabilities acquired during tumor development—cancer hallmarks—would evolve to 14 tenets as knowledge ...
Eleonora Sementino +3 more
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Mitochondrial Akt Regulation of Hypoxic Tumor Reprogramming
Cancer Cell, 2016Young Chan Chae +2 more
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