Results 71 to 80 of about 590,284 (209)

Identification and Isolation of Active Compounds from Astragalus membranaceus that Improve Insulin Secretion by Regulating Pancreatic Β-Cell Metabolism

open access: yesBiomolecules, 2019
In type 2 diabetes (T2D), insufficient secretion of insulin from the pancreatic β-cells contributes to high blood glucose levels, associated with metabolic dysregulation.
Dahae Lee   +5 more
doaj   +1 more source

A,B. Phospho-AKT-Ser473 Western blot analysis of lymphatic endothelial cells.

open access: yes, 2018
Note that phospho-AKT-Ser473 (pAKT) is highly expressed in lymphatic malformation-derived LECs (Ly-LEC1, 2, 10, and 12), but not in normal HD-LECc3 and c4. Total AKT (tAKT) is found in all cell lines.
Hannah Blesinger (5492933)   +7 more
core   +1 more source

Transient activation of FOXN1 in keratinocytes induces a transcriptional programme that promotes terminal differentiation: contrasting roles of FOXN1 and Akt [PDF]

open access: yes, 2004
The forkhead transcription factor FOXN1 is required for normal cutaneous and thymic epithelial development. Mutations in FOXN1 give rise to the nude phenotype in mice, rats and man. However, the genes that are regulated by FOXN1 are unknown.
Ofstad, T.A.   +14 more
core   +1 more source

Heat shock protein 47 promotes tumor survival and therapy resistance by modulating AKT signaling via PHLPP1 in colorectal cancer

open access: yesCancer Biology & Medicine, 2020
Objective: Heat shock protein 47 (HSP47) is a collagen-specific molecular chaperone that facilitates collagen maturation. Its role in cancer remains largely unknown.
Yijye Chern   +3 more
doaj   +1 more source

Additional file 1: of MIG-6 suppresses endometrial epithelial cell proliferation by inhibiting phospho-AKT

open access: yes, 2018
Figure S1 Total AKT level is not changed in Mig-6 f/f and Mig-6 d/d mice. (A) The expression of AKT in the uteri of Mig-6 f/f (a) and Mig-6 d/d (b) mice and (B) H-score of AKT in the uteri of Mig-6 f/f and Mig-6 d/d mice.
Jung-Yoon Yoo (462528)   +5 more
core   +1 more source

Cytoplasmic Endonuclease G promotes nonalcoholic fatty liver disease via mTORC2-AKT-ACLY and endoplasmic reticulum stress

open access: yes, 2023
This supplementary data supported our findings that ENDOG promoted mTORC2-AKT-ACLY activation and ER stress, which finally promoted lipid ...
Wenjun Wang (16890071)
core   +1 more source

Cigarette-Specific Carcinogen Induces Stabilization of DNA methyltransferases through AKT/GSK3β/βTrCP Pathway in Lung Cancer [PDF]

open access: yes, 2011
[[abstract]]Background: Most lung cancer cases are caused by cigarette-specific carcinogens, such as nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Previous studies have shown that NNK induces promoter hypermethylation of several tumor
Yi-Shuan Hsieh, 謝翊萱
core  

TBP-1 (TAT BINDING PROTEIN-1) IN THE CONTROL OF CELL PROLIFERATION: FUNCTIONAL RELATIONSHIP WITH THE AKT/PKB SIGNALING PATHWAY [PDF]

open access: yes, 2011
TBP-1/Tat-Binding Protein 1 (also named Rpt-5, S6a or PSMC3) is a multifunctional protein, originally identified as a regulator of HIV-1-Tat mediated transcription.
Festa, Luisa
core   +1 more source

ErbB2 signaling in breast cancer : the role of ErbB, Akt and ShcA phosphorylation [PDF]

open access: yes, 2004
Breast cancer is the most common malignancy in women and is estimated to account for more than 200,000 new cancer cases in the United States in the year 2002. It now represents the second leading cause of death (40,000) from cancer in women.
Cicenas, Jonas
core   +1 more source

Dokumentacja techniczna z lat 1919–1939 w zespole akt Ministerstwa Spraw Wewnętrznych przechowywanym w zasobie Archiwum Akt Nowych

open access: yesArchiwa - Kancelarie - Zbiory, 2015
Artykuł omawia dzieje oraz zawartość kolekcji dokumentacji technicznej z lat 1919–1939, wchodzącej w skład przechowywanego w zasobie Archiwum Akt Nowych zespołu akt Ministerstwa Spraw Wewnętrznych w Warszawie 1918–1939.
Adam Grzegorz Dąbrowski
doaj  

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