Results 71 to 80 of about 532,309 (312)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Endothelin-1 promotes myofibroblast induction through the ETA receptor via a rac/phosphoinositide 3-kinase/akt-dependent pathway and is essential for the enhanced contractile phenotype of fibrotic fibroblasts

, 2004
The endothelins are a family of endothelium-derived peptides that possess a variety of functions, including vasoconstriction. Endothelin-1 (ET-1) is up-regulated during tissue repair and promotes myofibroblast contraction and migration, hence ...
Abraham, DJ, du Bois, R M, Denton, CP, Black, C M, Chen, YL, Chen, Y L, Chen, Y, Shi-Wen, X., Renzoni, E.A., Denton, C P, Shi-Wen, X, Leask, A., Pearson, J D, Xu, SW, Bou-Gharios, George, du Bois, RM, Xu, S W, Dashwood, M, Denton, C.P., Bou-Gharios, G., Renzoni, E A, Pearson, JD, Chen, Y., Abraham, D.J., Abraham, D J, Renzoni, EA, Black, CM, Dashwood, M., Eastwood, M, Leask, A, Eastwood, M., Black, C.M., Pearson, J., du Bois, R., Bou-Gharios, G   +34 more
core   +1 more source

The FOXO’s Advantages of Being a Family: Considerations on Function and Evolution

Cells, 2020
The nematode Caenorhabditis elegans possesses a unique (with various isoforms) FOXO transcription factor DAF-16, which is notorious for its role in aging and its regulation by the insulin-PI3K-AKT pathway.
Michel Schmitt-Ney
doaj   +1 more source

High Norepinephrine State Induces Growth of Colorectal Cancer Cells via ADP-Ribosyltransferase 1 in Type 2 Diabetes Mellitus

Frontiers in Bioscience-Landmark, 2023
Background: Patients with type 2 diabetes mellitus have a higher susceptibility for colorectal cancer and poorer prognosis, but the mechanism is still unknown.
Wenwen Chen, Hailun Xie, Ming Xiao, Ming Li, Yi Tang, Shuxian Zhang, Xiujun Li, Yalan Wang   +7 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Identification and Isolation of Active Compounds from Astragalus membranaceus that Improve Insulin Secretion by Regulating Pancreatic Β-Cell Metabolism

Biomolecules, 2019
In type 2 diabetes (T2D), insufficient secretion of insulin from the pancreatic β-cells contributes to high blood glucose levels, associated with metabolic dysregulation.
Dahae Lee, Da Hye Lee, Sungyoul Choi, Jin Su Lee, Dae Sik Jang, Ki Sung Kang   +5 more
doaj   +1 more source

BYSL contributes to tumor growth by cooperating with the mTORC2 complex in gliomas

Cancer Biology & Medicine, 2021
Objective: BYSL, which encodes the Bystin protein in humans, is upregulated in reactive astrocytes following brain damage and/or inflammation. We aimed to determine the role and mechanism of BYSL in glioma cell growth and survival.
Shangfeng Gao, Zhuang Sha, Junbo Zhou, Yihao Wu, Yunnong Song, Cheng Li, Xuejiao Liu, Tong Zhang, Rutong Yu   +8 more
doaj   +1 more source

Akt Goes Cycling [PDF]

Cancer Control, 2014
AKT kinase is an important signaling molecule in multiple cell types, relaying cues of growth, proliferation, and survival 1–3. AKT interacts with regulatory networks to feed extracellular signals into transcriptional programs within cells that eventually dictate the cell state. Its activation impacts a number of physiological processes such as glucose
Kiran N, Mahajan, Nupam P, Mahajan
openaire   +2 more sources

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source