Results 61 to 70 of about 590,284 (209)

Effects of MRE11 on Apoptosis and Proliferation of Esophageal Squamous Cancer Cells

Zhongliu Fangzhi Yanjiu, 2022
Objective To investigate the effect of MRE11 on the proliferation and apoptosis of esophageal squamous cancer cells and its molecular mechanism. Methods MRE11 expression was downregulated by MRE11 siRNA transfection in esophageal squamous cancer cells ...
ZHANG Yan, ZHANG Hongrui, MENG Dandan, YI Zhenying, XU Zhiqiao   +4 more
doaj   +1 more source

Effect of ellagic acid on BDNF/PI3K/AKT-mediated signaling pathways in mouse models of depression [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): The aim of this study is to investigate the possible role of the hippocampal BDNF-PI3K-AKT signaling pathway in the antidepressant-like activity of ellagic acid (EA) in mice.Materials and Methods: Male BALB/C mice were divided into 5 groups;
Aslı Bedel, Coskun Usta
doaj   +1 more source

Akt in the pathogenesis of COPD [PDF]

International Journal of COPD, 2006
In this review we consider the therapeutic potential of targeting Akt for the treatment of COPD. Akt is a serine/threonine protein kinase that functions as a signaling intermediate linked to multiple signaling programs involved in survival, inflammation, and growth. Akt is closely associated with key membrane-bound receptors and represents a convergent
Bozinovski, S, Vlahos, R, Hansen, M, Liu, K, Anderson, GP   +4 more
openaire   +3 more sources

Figure 8: NDNF Rejuvenated Old hBM-MSCs and Improved Cardiac Function Through Activation of p-Akt

, 2019
(A) The phosphorylated Akt (p-Akt) level in old NDNF-transduced hBM-MSCs (old+NDNF) was significantly higher than in empty vector–transduced cells (old). (B) Western blotting showed the expression of p-Akt protein in the border area of mouse heart tissue
Ren-Ke Li (567108), Hui-Fang Song (6822266), Xiao-Yan Zhai (6822275), Jun Wu (4002), Sheng He (176728), Hui Gong (203677), Zheng-Bo Shao (6822272), Li Lu (68660), Jun Xie (53987), Wen-Juan Yin (6822269), Shu-Hong Li (387185), Richard D. Weisel (659770), Jian Guo (191157), Fang Wei (31236)   +13 more
core   +1 more source

A gammaherpesvirus complement regulatory protein promotes initiation of infection by activation of protein kinase Akt/PKB. [PDF]

, 2010
Viruses have evolved to evade the host's complement system. The open reading frames 4 (ORF4) of gammaherpesviruses encode homologs of regulators of complement activation (RCA) proteins, which inhibit complement activation at the level of C3 and C4 ...
Stewart, James P., Stipan, J., Adler, Heiko, James P Stewart, Adler Barbara, Adler, Barbara, Heiko Adler, Beatrix Steer, Barbara Adler, Jonjic Stipan, Stipan Jonjic, Steer, Beatrix, Steer Beatrix, Steer, B., Adler Heiko, Stewart James P., Adler, H., Adler, B., Jonjic, Stipan, James P. Stewart, Stewart, J.P.   +20 more
core   +1 more source

Akt Goes Cycling [PDF]

Cancer Control, 2014
AKT kinase is an important signaling molecule in multiple cell types, relaying cues of growth, proliferation, and survival 1–3. AKT interacts with regulatory networks to feed extracellular signals into transcriptional programs within cells that eventually dictate the cell state. Its activation impacts a number of physiological processes such as glucose
Kiran N, Mahajan, Nupam P, Mahajan
openaire   +2 more sources

Akt inhibitor deguelin aggravates inflammation and fibrosis in myocarditis [PDF]

Iranian Journal of Basic Medical Sciences, 2019
Objective(s): Myocarditis is characterized by inflammatory cell infiltration in myocardial stroma. Attenuation of tumor necrosis factor (TNF)-α and interleukin (IL)-1β is a reliable mark for improving the prognosis.
Shanshan Li, Yue Wang, Chunming Zhao, Meixiang Zhang, Wei Wang, Xiaowei Yu, Jiao Huang, Zhao Wang, Bo Zhu, Cheng qian Yin, Hongxing Cai   +10 more
doaj   +1 more source

The FOXO’s Advantages of Being a Family: Considerations on Function and Evolution

Cells, 2020
The nematode Caenorhabditis elegans possesses a unique (with various isoforms) FOXO transcription factor DAF-16, which is notorious for its role in aging and its regulation by the insulin-PI3K-AKT pathway.
Michel Schmitt-Ney
doaj   +1 more source

Phosphorylation of HDM2 by Akt [PDF]

Oncogene, 2002
The HDM2 protein is a key regulator of the tumour suppressor, p53. Control of HDM2 function is critical for normal cell proliferation and stress responses, and it is becoming evident that multiple modifications of HDM2 can regulate its function within cells.
Margaret, Ashcroft, Robert L, Ludwig, Douglas B, Woods, Terry D, Copeland, H Oliver, Weber, Elizabeth J, MacRae, Karen H, Vousden   +6 more
openaire   +2 more sources

Lukijatutkimus AKT-lehdelle [PDF]

, 2023
Järjestölehdille on erityisen tärkeää tuntea lukijakuntansa, sekä mitä he haluavat lehdeltä. Tutkimalla lehden lukijoita ja palautetta keräämällä pyritään tilanteeseen, jossa lehden lukijat ovat mahdollisimman tyytyväisiä.
Iivari, Arttu
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