Results 81 to 90 of about 590,284 (209)
Journal of Ardabil University of Medical Sciences, 2022 Background & objectives: Parkinson's disease is a progressive neurological disorder associated with the destruction of dopaminergic neurons in the substantia nigra. Physical exercise can control the risk of neuronal damage.
Mansooreh Shamsi Soshab +2 more
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Akt suppresses DLK for maintaining self-renewal of mouse embryonic stem cells
, 2017 Mouse embryonic stem cells (ES cells) can proliferate indefinitely. To identify potential signals involved in suppression of self-renewal, we previously screened a kinase/phosphatase expression library in ES cells, and observed that inhibition of Dual ...
呂立 +1 more
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Proteomic investigation of the class IA phosphoinositide 3-kinase signalling pathway [PDF]
, 2012 PhDClass IA phosphoinositide 3-kinases (PI3Ks) are a family of enzymes with key roles in the regulation of signalling pathways, many of which are mediated through Akt.
Beltran, Luisa
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Diabetes: Caught in the Akt? [PDF]
Kidney International, 2007 One complication of diabetes is a pronounced renal cellular hypertrophy, inevitably resulting in chronic fibrotic changes. Chuang and colleagues demonstrate that hypertrophy in vitro is dependent on an increased phosphoinositide 3-kinase (PI3K) activity and is correlated with increased levels of p21(WAF1/Cip1), a cell-cycle regulator that was ...
openaire +2 more sources
Neural Regeneration ResearchCerebral edema caused by blood–brain barrier injury after intracerebral hemorrhage is an important factor leading to poor prognosis. Human-induced pluripotent stem cell–derived neural stem cell exosomes (hiPSC–NSC–Exos) have shown potential for brain ...
Conglin Wang +11 more
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, 2018 Figure S2 Total AKT level is not changed in Mig-6 d/d mice after P4 treatment. (A) The expression of AKT in the uteri of vehicle (a) and P4 (b) treated Mig-6 d/d mice and (B) H-score of AKT in the uteri of vehicle and P4 treated Mig-6 d/d mice. (PPTX 407
Jung-Yoon Yoo (462528) +5 more
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Constitutive activation of the PI3K-Akt-mTORC1 pathway sustains the m.3243 A > G mtDNA mutation.
, 2021 Mutations of the mitochondrial genome (mtDNA) cause a range of profoundly debilitating clinical conditions for which treatment options are very limited. Most mtDNA diseases show heteroplasmy - tissues express both wild-type and mutant mtDNA.
Kritarth Singh (10726895) +12 more
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Cells, 2019 The activation of hepatic stellate cells (HSCs) manifested as proliferation and migration is the pivotal event involved in liver fibrogenesis. The vimentin network, an intermediate filament (IF) system, is one of the critical cascades by which the cell ...
Pei-Wen Wang +5 more
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Анналы клинической и экспериментальной неврологии, 2018 Introduction. Ischemic stroke is one of the most common and socially significant diseases, and its pathogenesis is associated with oxidative stress. The study of mechanisms of the neuroprotective action of the natural antioxidant carnosine is promising ...
Olga M. Lopacheva +9 more
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Drug Design, Development and Therapy, 2020 Liang-Jian Hong, Ai-Jun Chen, Feng-Zeng Li, Ke-Jun Chen, Sheng Fang Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, People’s Republic of ChinaCorrespondence: Sheng FangDepartment of ...
Hong LJ, Chen AJ, Li FZ, Chen KJ, Fang S
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