Results 141 to 150 of about 37,267 (288)
Current methods of diagnosis and monitoring of a systemic amyloidosis course
Aim. To determine clinical significance of measuring blood levels of protein precursors of AA- and AL-amyloidosis - SAA and immunoglobulin free light chains (ILC), respectively. Material and methods.
Vilen Vilevich Rameev+13 more
doaj
Investigating Local Sequence‐Structural Attributes of Amyloidogenic Light Chain Variable Domains
ABSTRACT Light chain amyloidosis is a medical condition characterized by the aggregation of misfolded antibody light chains into insoluble amyloid fibrils in the target organs, causing organ dysfunction, organ failure, and death. Despite extensive research to understand the factors contributing to amyloidogenesis, accurately predicting whether a given ...
Puneet Rawat+6 more
wiley +1 more source
Treatment options for severe cardiac amyloidosis: heart transplantation combined with chemotherapy and stem cell transplantation for patients with AL-amyloidosis and heart and liver transplantation for patients with ATTR-amyloidosis☆ [PDF]
Falk‐Udo Sack+6 more
openalex +1 more source
This review presents a detailed overview of clinically approved nanoparticle therapeutics, classifying them by type and discussing their unique advantages in drug delivery. It highlights regulatory challenges across global markets and emphasizes the need for adaptive approval pathways.
Nimeet Desai+5 more
wiley +1 more source
Therapeutic Implications of Biomolecular Corona on Lipid Nanoparticle‐Based Gene Delivery Systems
This image illustrates the role of the biomolecular corona in lipid nanoparticles (LNPs), highlighting its impact on the stability, immune response, biodistribution, and targeted delivery. Formed after injection, the corona influences how LNPs circulate, interact with the cells, and modulate the immune response.
Antonietta Greco, Claudia Corbo
wiley +1 more source
A Case of Multiple Myeloma with AL Amyloidosis Successfully Treated with Autologous Stem Cell Transplantation [PDF]
Ha-young Lee+4 more
openalex +1 more source
Lipid Nanoparticles for Delivery of CRISPR Gene Editing Components
The review presents a comprehensive overview of each component of lipid nanoparticles(LNPs)and their effects on editing efficiency. It specifically highlights strategies for achieving non‐liver delivery, aiming for broader applications in gene editing. Furthermore, this review summarizes the applications of LNPs in gene editing and offers insights for ...
Fan Wu+6 more
wiley +1 more source
The molecular landscape of AL amyloidosis. [PDF]
Zvida-Bloch T+4 more
europepmc +1 more source