Results 171 to 180 of about 10,911,887 (292)

Extracellular matrix remodeling upregulates hippocampal neurogenic niche stiffness and impairs neurogenesis in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION Preserving adult hippocampal neurogenesis alleviates cognitive deficits in Alzheimer's disease (AD), yet how biophysical alterations in such as stiffness in the neurogenic niche regulate neurogenesis remains unclear. METHODS Stiffness in the hippocampal dentate gyrus subgranular cell zone (SGZ) of 5×FAD mice was measured using ...
Weiqi Sun, Biyu Yang, Hanyuan Zheng, Qi Wang, Yajiao Shi, Gandig Wang, Wang Yin, Hui Wang, Xuetao Qi, Yun Yao, Jiaxin Wang, Shuang Cui, Kun Cui, Jian Mao, Yiyuan Xia, Jianwen Deng, Siyuan Zhao, Zhihao Wang, Fengyu Liu, Ming Yi, Jiuyang Ding, Weidong Le, Xinyan Li, Junliang Yuan, You Wan, Jie Zheng   +25 more
wiley   +1 more source

Reduced heart rate variability is associated with disease severity in AL amyloidosis: a retrospective cohort study. [PDF]

Front Med (Lausanne)
Pei XH, Zuo SQ, Zhou P, Ma RJ, Zhu ZM, Yuan XL.   +5 more
europepmc   +1 more source

Neurobiological mechanisms of 40‐Hz stimulation in Alzheimer's disease: evidence, heterogeneity, and constraints

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract Early disruption of gamma oscillations is increasingly recognized as a contributor to neurodegeneration and cognitive decline in Alzheimer's disease (AD), positioning 40‐Hz stimulation as a promising neuromodulatory strategy. However, its neurophysiological and cognitive effects remain highly variable across studies, underscoring the need for ...
Lin Qi, Weiye Wang, Reema Abdullah, Yilei Zhao, Zhibin Wang, Yi Tang, Benyan Luo, Guoping Peng   +7 more
wiley   +1 more source

Chemoenzymatic Synthesis of Well‐Defined α(2,8)‐ and α(2,9)‐Linked Oligosialosides

Angewandte Chemie, Volume 138, Issue 36, 1 September 2026.
Well‐defined α(2,8)‐ and α(2,9)‐linked oligosialic acids of different lengths can be prepared by employing recombinant bacterial polysialyltransferases in combination with chemically modified CMP‐Neu5Ac derivatives. After transfer, a sialoside is formed bearing an artificial entity, which blocks further glycosylation.
Jelle A. Fok, Keshav Kishor, Mehman I. Bunyatov, Gerlof P. Bosman, Geert‐Jan Boons   +4 more
wiley   +2 more sources

Diagnostic utility of immunofixation and free light chain assay in AL amyloidosis: a systematic review and meta-analysis. [PDF]

Blood Adv
Azzam M, Hamarsha Q, Kawtharany H, Nazzal J, Alkhader A, Khraise T, AlMasri MM, Abou Zeid HK, Alwan I, Jaber N, Seftel MD, Aguirre MA, Boedicker D, Bumma N, Carroll A, Comenzo R, Cook J, Dasgupta N, De La Torre AH, Dispenzieri A, Jamal F, Khouri J, Picken MM, Raza S, Leung N, Sanchorawala V, Sarswat N, Shaikh H, Singh D, Kukreti V, Mustafa RA.   +30 more
europepmc   +1 more source

MCH‐Guard: Multimodal machine learning framework for risk stratification of cerebral microhemorrhage risk in the Alzheimer's Disease Neuroimaging Initiative

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION Efficient cerebral microhemorrhage (MCH) monitoring is critical for anti‐amyloid therapy safety due to amyloid‐related imaging abnormalities with hemosiderin deposition (ARIA‐H) risk. We developed MCH‐Guard, a multimodal machine‐learning framework, to stratify MCH risk for Alzheimer's Disease Neuroimaging Initiaitive (ADNI ...
Alper Gel, Eliana Phillips, Isabella Hausle, Pamela Thropp, Duygu Tosun, for the Alzheimer's Disease Neuroimaging Initiative   +5 more
wiley   +1 more source

Limited duration of dexamethasone in newly diagnosed AL amyloidosis: impact on response, toxicity, and survival. [PDF]

Ann Med
Hanna J, Li H, Brown R, Burney ZA, Abdallah K, Basali D, Valent J, Samaras C, Anwer F, Khouri J, Raza S, Van Heeckeren W, Hanna M, Finet JE, Williams L, Mazzoni S.   +15 more
europepmc   +1 more source

Baseline cerebrospinal fluid complement balance is associated with longitudinal memory decline in relation to plasma p‑tau181 levels in mild cognitive impairment

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION The role of complement in Alzheimer's disease (AD) remains unclear, particularly regarding tau pathology and memory decline. METHODS In 123 mild cognitive impairment (MCI) participants from Alzheimer's Disease Neuroimaging Initiative (ADNI), linear mixed‑effects models and Johnson–Neyman analysis examined associations of baseline ...
Zhinan Ye, Qihan Zhang, Bo Zhang, Bingxin Teng, Shiyue Wang, Jiaxuan Chen, Bohao Li, Hongjie Jin, Zhexin Zheng, Zhuoyu Yang, Xuanang Hu, Xinyan Zhao, Suwen Huang, Yiyun Weng, Dehao Yang   +14 more
wiley   +1 more source

Determinants of gastrointestinal disease burden and survival in systemic AL amyloidosis. [PDF]

Blood Adv
Steinhardt MJ, Muchtar E, Kourelis T, Warsame R, Mauermann ML, Buadi FK, Dingli D, Leung N, Cook J, Go RS, Hayman SR, Gonsalves WI, Kapoor P, Zanwar S, Binder M, Hellou T, Tan M, Halawi H, Fonder A, Hobbs M, Abdallah N, Lin Y, Siddiqui MA, Kyle RA, Kortüm KM, Einsele H, Rajkumar SV, Kumar SK, Gertz MA, Dispenzieri A.   +29 more
europepmc   +1 more source

Synergistic association of insomnia and anxiety with cognitive impairment and dementia in older adults

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION We investigated the synergistic effects of comorbid insomnia and anxiety on cognitive impairment and dementia and explored the underlying plasma biomarker mechanisms. METHODS We included adults ≥ 60 years from the cross‐sectional cohort named The Shanghai Action to Prevent Dementia in the Elderly (SHAPE) and used data from the ...
Yan Chen, Qianxi Wang, Ling Li, Shixing Qian, Li Bai, Tih Shih Lee, Shaowei Zhang, Yaping Li, Qianqian Guo, Yang Yang, Feng Yan, Lei Feng, Xia Li   +12 more
wiley   +1 more source