Results 181 to 190 of about 54,210 (294)

Contributions of the Alzheimer's Disease Neuroimaging Initiative to advancing AD research: a targeted review of recent publications

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract The Alzheimer's Disease Neuroimaging Initiative (ADNI) recently celebrated its 20th anniversary, reflecting two decades of major contributions to Alzheimer's research through open data sharing and longitudinal multimodal assessments. This review synthesizes 122 high‐impact studies using ADNI data or biospecimens from 2023 to mid‐2025 to ...
Dallas P. Veitch, Melanie J. Miller, Shaveta Kanoria, Paul S. Aisen, Laurel A. Beckett, Robert C. Green, Danielle J. Harvey, Clifford R. Jack Jr., William Jagust, Edward B. Lee, Kwangsik Nho, Rachel Nosheny, Ozioma C. Okonkwo, Richard J. Perrin, Ronald C. Petersen, Monica Rivera Mindt, Andrew J. Saykin, Leslie M. Shaw, Arthur W. Toga, Duygu Tosun, Susan M Landau, Michael W. Weiner, for the Alzheimer's Disease Neuroimaging Initiative   +22 more
wiley   +1 more source

A Case of AL Amyloidosis With Hepatomegaly as the Main Clinical Manifestation. [PDF]

Clin Case Rep
Dong S, Lv R, Wang W, Gao G, Zhao M, Ma X.   +5 more
europepmc   +1 more source

Early microglial response to amyloid plaques drives sleep loss in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION Sleep disruption is an early feature of Alzheimer's disease (AD), but the cellular mechanisms linking amyloid pathology to sleep loss remain unclear. METHODS Electroencephalography/electromyography (EEG/EMG) recordings, quantitative EEG analysis, and sleep deprivation were performed in APPswe/PSEN1dE9 (APP/PS1) mice at different ...
Nicholas J. Constantino, Riley E. Irmen, Matthew J. Lanning, Sierra M. Turner, Clair C. Ashley, Caitlin M. Carroll, Evan M. Neary, Dave Rubinow, J. Andy Snipes, Shannon L. Macauley   +9 more
wiley   +1 more source

Cortical gray–white matter contrast alterations precede amyloid‐β positivity and macrostructural changes in older adults without dementia

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION Early Alzheimer's disease (AD) involves subtle cortical changes that may precede atrophy. Magnetic resonance imaging (MRI) microstructural markers may detect earlier pathology than classical morphometry. METHODS We analyzed cross‐sectional MRI and amyloid‐β (Aβ) positron emission tomography (PET) data from 1323 non‐demented AMYPAD
Leonard Pieperhoff, Luigi Lorenzini, Francisco Almeida, Mario Tranfa, Ariane Bollack, Prithvi Arunachalam, Federico Masserini, Robin Wolz, Sylke Grootoonk, Craig Ritchie, Mercè Boada, Marta Marquié, Jort Vijverberg, Rik Vandenberghe, Bernard J. Hanseeuw, Pablo Martinez‐Lage, Pierre Payoux, Pieter Jelle Visser, Michael Schöll, Giovanni B. Frisoni, Matteo Pardini, Luca Roccataglia, Andrew W. Stephens, Chris Buckley, Gill Farrar, Frank Jessen, Juan Domingo Gispert, Gemma Salvadó, Emma S. Luckett, Henk‐Jan MM Mutsaerts, Alle Meije Wink, Lyduine E. Collij, Frederik Barkhof, Tiago Gil Oliveira, the AMYPAD consortium   +34 more
wiley   +1 more source

AL amyloidosis: a real-world experience with CAR T-cell therapy. [PDF]

Blood Adv
Tan MSY, Warsame R, Parrondo R, Muchtar E, Kourelis T, Buadi F, Gonsalves W, Cook J, Kapoor P, Hayman S, Dingli D, Binder M, Leung N, Roy V, Sher T, Wiedmeier-Nutor JE, Chhabra S, Fonseca R, Abdallah N, Rajkumar SV, Kumar SK, Gertz M, Lin Y, Dispenzieri A.   +23 more
europepmc   +1 more source

Blood‐based proteomic signature of amyloidosis: identification of novel regulators of amyloid load

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION Cerebral amyloidosis is a defining feature of Alzheimer's disease (AD), yet the molecular heterogeneity among amyloidbeta‐positive (Aβ+) individuals remains poorly defined. We aimed to map the proteomic correlates of cerebral amyloidosis and link them to clinical variability within Aβ+ individuals.
Yike Chen, Michael R. Duggan, Jigyasha Timsina, Ying Xu, Daniel Western, Katherine Gong, Menghan Liu, John Budde, Suzanne E. Schindler, John C. Morris, David M. Holtzman, Tammie L. S. Benzinger, Brian A. Gordon, Mahdi Moqri, Knight Alzheimer Disease Research Center (Knight‐ADRC), Laura Ibanez, Keenan A. Walker, Carlos Cruchaga, Muhammad Ali   +18 more
wiley   +1 more source

Patient with AL amyloidosis with recurrent syncope as the first symptom: case report and literature review. [PDF]

Front Oncol
Hu L, Luo L, Yao N, Mi J, Zhang Y, Sun M, Wang H, Xu Y, Wang W, Hu J, Lu H.   +10 more
europepmc   +1 more source

Long‐Term Outcomes of Reduced‐Intensity Conditioning Hematopoietic Stem Cell Transplantation for Patients With Systemic Sclerosis With Impaired Cardiac Function

Arthritis &Rheumatology, Volume 78, Issue 6, Page 1294-1305, June 2026.
Objective High‐intensity conditioning autologous hematopoietic stem cell transplantation (AHSCT) is standard of care for patients with advanced systemic sclerosis (SSc). The role of reduced‐intensity conditioning (RIC) before AHSCT in this population remains unclear.
Yonatan Lean, Carrie Richardson, Anthony J. Esposito, Katy Bedjeti, George E. Georges   +4 more
wiley   +1 more source

Eligibility criteria for clinical trials in AL amyloidosis result in exclusion of nearly half of real-world patients. [PDF]

Hemasphere
Bellofiore C, Basset M, Nuvolone M, Nanci M, Sanna GD, Di Simone VA, Fogliani A, Di Cecca M, Mussinelli R, Foli A, Ghazi Esfahani M, Sadrzadeh M, Perlini S, De Luca L, Clavreul S, Merlini G, Palladini G, Milani P.   +17 more
europepmc   +1 more source

The psychological experience of living at risk of an autosomal dominant neurological condition: A scoping review

Alzheimer's &Dementia: Behavior &Socioeconomics of Aging, Volume 2, Issue 2, June 2026.
Abstract As our understanding of genetic risk and the availability of genetic testing increases, consideration of the psychological impact of living at risk for an autosomal dominant neurological condition (ADNC) becomes more pertinent. A systematic search of PsycINFO, MEDLINE, and Web of Science was run to identify studies exploring the psychological ...
Rhianna Brien, Simon Mead, Marc Tibber, Edgar Chan   +3 more
wiley   +1 more source