Results 191 to 200 of about 10,911,887 (292)

Modulating the Gut‐Microbiota‐Brain Axis in Alzheimer's Disease: Therapeutic Potential of Nutritional and Metabolic Factors

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
This review systematically examines the role of gut microbiota modulation in Alzheimer's disease, focusing on how microbial metabolites and dietary nutrients influence cognitive function and AD pathology, as well as the neuroprotective effects through the gut‐brain axis.
Binyue Xu, Xuhuan Li, Shangling Dong, Zheyuan Zhang, Dong Jin, Guoping Li, Jiesheng Wang   +6 more
wiley   +1 more source

Clinical and CT/MRI features of hepatic AL amyloidosis: preliminary experience in 10 cases. [PDF]

Front Oncol
Zhang Y, Wang W, Song W, Chang J, Li H.
europepmc   +1 more source

CRISPR‐Cas9 and precision editing technologies linking functional genomics to clinical translation in genetic diseases

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
CRISPR‐Cas9 and precision editing technologies enable a variant‐mechanism‐driven framework for genetic disease research and therapeutic development. Pathogenic variants are first interpreted according to mutation type, coding or regulatory consequence, tissue context, and disease mechanism.
Zijing Wen, Jianming Su
wiley   +1 more source

Long-Term Outcomes of Mayo Stage IIIb AL Amyloidosis Treated With Daratumumab-Based Frontline Therapy. [PDF]

Am J Hematol
Zhen S, Bandelita SN, Bhutani D, Maurer MS, Wats K, Brailovsky Y, Hughes MS, Radhakrishnan J, Coriu D, Mapara M, Lentzsch S, Chakraborty R.   +11 more
europepmc   +1 more source

Serum Bone‐, Muscle‐ and Fat‐ Derived Factors Sclerostin, Irisin and Leptin Show Different Correlations With Body Composition and Bone Mineral Density in Chinese Men With Obesity: A Cross‐Sectional Study

Diabetes/Metabolism Research and Reviews, Volume 42, Issue 6, September 2026.
ABSTRACT Aims This study aimed to explore the interactions among sclerostin, irisin and leptin, as well as their associations with body composition and bone metabolism in Chinese men with obesity. Materials and Methods This study included 26 men with normal weight and 78 men with obesity.
Xiang Chen, Sumin Shen, Mingxi Zou, Zhenlin Zhang, Nanwei Tong, Juan Li   +5 more
wiley   +1 more source

Multiple Myeloma Concomitant with AL Amyloidosis: Histopathological Aspects of the Common Plasma Cell Spectrum. [PDF]

Int J Mol Sci
Gioeva Z, Mikhaleva L, Tsutsaev A, Tebenkova A, Gutyrchik N, Shakhpazyan N, Ilyichev A, Kakturskij L.   +7 more
europepmc   +1 more source

Young Adult Microglial Deletion of C1q Reduces Engulfment of Synapses and Partially Mitigates Cognitive Impairment in an Aggressive Alzheimer's Disease Mouse Model

Glia, Volume 74, Issue 9, September 2026.
Young adult deletion of microglial C1q reduced engulfment of Vglut1+ synapses and mitigated spatial cognitive deficits at 10 months of age in the amyloidopathy Arctic mouse model of AD. Neither fibrillar amyloid plaques nor soluble or insoluble Aβ levels in the hippocampus were affected by young adult microglial loss of C1q despite reduced phagocytosis
Tiffany J. Petrisko, Shu‐Hui Chu, Angela Gomez‐Arboledas, Blossom Zhang, Andrea J. Tenner   +4 more
wiley   +1 more source

Pulmonary Artery Pressure Sensor-Guided Therapy for Cardiac AL Amyloidosis in a Young Multiple Myeloma Patient. [PDF]

JACC Case Rep
Knapen R, Theunissen K, Ghekiere O, Houbrechts M, Timmermans P.   +4 more
europepmc   +1 more source

A Microglia–Astrocyte Signaling Axis Regulates Astrocyte Piezo1 Expression and Inflammatory Responses

Glia, Volume 74, Issue 9, September 2026.
Activated microglia‐derived inflammatory signals drive astrocytic Piezo1 expression in both in vitro and in vivo models. Piezo1 upregulation modulates astrocytic Ca2+ dynamics and inflammatory gene expression, thereby limiting microglial activation. ABSTRACT Structural tissue alterations in numerous brain disorders can initiate mechanosensory signaling
Yanyang Bai, Hyun B. Choi, Stefan Wendt, Morgan Towriss, Ada J. Lin, Christopher J. Groten, Ivy Cui, Haakon B. Nygaard, Brian A. MacVicar   +8 more
wiley   +1 more source

Primary (AL) Amyloidosis Following COVID-19 Infection: A Case Report. [PDF]

Clin Case Rep
Gholami N, Tahsini Tekantapeh S, Khalaji A, Nejati B, Ravaei G.   +4 more
europepmc   +1 more source