Results 11 to 20 of about 10,911,887 (292)
Misdiagnosis of Hereditary Amyloidosis as AL (Primary) Amyloidosis [PDF]
New England Journal of Medicine, 2002 Hereditary, autosomal dominant amyloidosis, caused by mutations in the genes encoding transthyretin, fibrinogen A alpha-chain, lysozyme, or apolipoprotein A-I, is thought to be extremely rare and is not routinely included in the differential diagnosis of systemic amyloidosis unless there is a family history.We studied 350 patients with systemic ...
Lachmann, H.J. +7 more
openaire +5 more sources
Daratumumab in AL amyloidosis [PDF]
Blood, 2022 Abstract Light-chain amyloidosis has come far, with the first treatment getting regulatory approval in 2021. Daratumumab-based regimens achieve deep hematologic and organ responses, offering a new therapeutic backbone. Early identification, correct fibril typing, challenges of the very advanced patient, and lack of therapies to remove ...
Ashutosh D. Wechalekar +1 more
core +5 more sources
A RARE PRESENTATION OF SYSTEMIC AL AMYLOIDOSIS; PULMONARY AL AMYLOIDOSIS
Hematology, Transfusion and Cell Therapy, 2022 Objective: Involvement of the lung is common in systemic AL amyloidosis in post-mortem series. However, the diagnosis is challenging. Histology is the gold standard but may result in bleeding. Consequently, diagnosis during life is rare.
Simge ERDEM +4 more
doaj +2 more sources
Biomarkers in AL Amyloidosis [PDF]
International Journal of Molecular Sciences, 2021 Systemic AL amyloidosis is a rare complex hematological disorder caused by clonal plasma cells which produce amyloidogenic immunoglobulins. Outcome and prognosis is the combinatory result of the extent and pattern of organ involvement secondary to amyloid fibril deposition and the biology and burden of the underlying plasma cell clone.
Despina Fotiou +2 more
openaire +3 more sources
Multiomics Insights Into AL Amyloidosis
Medicine Bulletin, EarlyView.Light chain amyloidosis is a systemic or localized protein conformational disorder triggered by misfolded immunoglobulin light chains, leading to amyloid fibril deposition.
Zixuan Zhang +6 more
core +2 more sources
AL amyloidosis enhances development of amyloid A amyloidosis [PDF]
British Journal of Dermatology, 2007 Contains fulltext : 52125.pdf (Publisher’s version ) (Open Access)
Hilst, J.C.H. van der +3 more
openaire +1 more source
Dysregulation of miRNAs In AL Amyloidosis [PDF]
Blood, 2010 Abstract Abstract 4648 Bone marrow plasma cells (BMPC) were purified from aspirates obtained from patients with AL amyloidosis using anti-CD138 immunomagnetic beads, and from controls. Expression levels of micro RNAs (miRNAs) were compared by microarray.
Liangping, Weng +5 more
openaire +2 more sources
Senile Systemic Amyloidosis: Clinical Features at Presentation and Outcome [PDF]
, 2013 Background Cardiac amyloidosis is a fatal disease whose prognosis and treatment rely on identification of the amyloid type. In our aging population transthyretin amyloidosis (ATTRwt) is common and must be differentiated from other amyloid types.
Banypersad, SM +15 more
core +1 more source
Renal AA-amyloidosis in intravenous drug users - a role for HIV-infection? [PDF]
, 2012 Background: Chronic renal disease is a serious complication of long-term intravenous drug use (IVDU). Recent reports have postulated a changing pattern of underlying nephropathy over the last decades.
Grützmacher, Peter +17 more
core +2 more sources
Structural analysis of ex vivo amyloid fibrils from AL amyloidosis
, 2023 The disease AL amyloidosis is caused by the misfolding of immunoglobulin light chains (LC). Due to an underlying plasma cell dyscrasia, amyloidogenic LCs are overproduced and their high serum concentrations lead to aggregation and amyloid fibril ...
Radamaker, Lynn
core +1 more source