Results 201 to 210 of about 51,767 (241)

PBX1 Improves Cognition and Reduces Amyloid‐β Pathology in APP/PS1 Mice by Transcriptionally Activating the CRTC2–CREB Pathway

Aging Cell, Volume 25, Issue 1, January 2026.
We found that the transcription factor PBX1 is markedly downregulated in patients with Alzheimer's disease and in disease models. Restoring PBX1 reduces Aβ pathology and rescues cognitive deficits. Mechanistically, PBX1 directly activates the transcription of CRTC2 and enhances p‐CREB signaling, thereby conferring neuroprotection.
Zinan Liu, Xiangyuan Meng, Rifeng Lu, Xiaoting Meng, Siyao Li, Yujie Wang, Xinpeng Liu, Xiaomei Liu, Jinyu Liu   +8 more
wiley   +1 more source

Monoclonal gammopathy of renal significance: overlap of AL amyloidosis and immunotactoid glomerulopathy. [PDF]

QJM
Kashio T, Horino T, Yagyu K, Osakabe Y, Inotani S, Terada Y.   +5 more
europepmc   +1 more source

The 3xTg‐AD Mouse Model of Alzheimer's Disease Exhibits Lifelong Reductions in Circulating Choline Despite Adequate Dietary Intake, With Sex‐Specific Neuropathological and Behavioral Phenotypes

Aging Cell, Volume 25, Issue 1, January 2026.
This study found that 3xTg‐AD mice exhibited lifelong reductions in circulating choline. Female 3xTg‐AD mice showed greater AD‐like pathology, whereas males displayed higher mortality, impulsivity, and water‐seeking behavior. These sex‐specific differences suggest distinct metabolic and behavioral vulnerabilities contributing to AD progression in this ...
Jessica M. Judd, Faizan Mistry, Wendy Winslow, Savannah Tallino, Julie Turk, Ramon Velazquez   +5 more
wiley   +1 more source

Amyloid Deposits in a Bone Marrow Biopsy Alongside a Presumed Causative Clone

eJHaem
Rahul Banerjee, Marie K. Das, Kelly D. Smith   +2 more
doaj   +1 more source

Diffuse lung involvement as a rare presentation of systemic AL amyloidosis: a retrospective cohort study. [PDF]

Blood Adv
Song A, Mellgard G, Bellofiore C, Basset M, Nuvolone M, Foli A, Merlini G, Maurer MS, Mapara MY, Bhutani D, Lentzsch S, Shaish H, Palladini G, Chakraborty R, Milani P.   +14 more
europepmc   +1 more source

Mapping VEXAS‐associated and rare UBA1 variants in the United Kingdom: Insights from patient cohorts and the general population

British Journal of Haematology, Volume 208, Issue 1, Page 116-128, January 2026.
VEXAS syndrome is a late‐onset inflammatory disorder with rheumatological and haematological features. Epidemiological studies of VEXAS syndrome so far have been limited. Analysis of various UK cohorts estimates the incidence of VEXAS to be 1.51/100 000, or 171 new cases in the population of men over the age of 50 who are being investigated for myeloid
Ana Martinez Rodriguez, Leon Chang, Dorota Rowczenio, Alexandra Smith, Ebun Omoyinmi, James A. Poulter, Andrew McGregor, Sebastian Francis, Roochi Trikha, Adam Al‐Hakim, Kar Lok Kong, David G. Kent, Helen Lachmann, Austin Kulasekararaj, Catherine Cargo, Sinisa Savic   +15 more
wiley   +1 more source

Exploring light chain cardiotoxicity in AL amyloidosis: Impact on hiPSC-derived Cardiomyocyte Activity

Serena C, Anthony F, Dario M, Luca B, Federica S, Rachele P, Luigi A, Carlo P, Mario N, Giovanni P, Stefano R, Ilaria R.   +11 more
europepmc   +1 more source

Improvement in global longitudinal strain following plasma cell-directed therapy is associated with long-term survival among patients with AL amyloidosis. [PDF]

Eur Heart J Open
Jang KH, Yu AF, Landau H, Ma X, Cheng RK, Mauer MS, Chuy KL, Lenihan D, Yang JC, Chen CL, Liu JE.   +10 more
europepmc   +1 more source

Correction: Utility of abdominal skin plus subcutaneous fat and rectal mucosal biopsy in the diagnosis of AL amyloidosis with renal involvement

, 2017
The PLOS ONE Staff
openalex   +2 more sources

Validation of a renal staging system and its association with renal amyloid deposition burden in AL amyloidosis. [PDF]

Ren Fail
Yao Y, Wang S, Li DY, Yu XJ, Liu JY, Qiu ZX, Zhou FD, Wang SX.   +7 more
europepmc   +1 more source