Results 51 to 60 of about 814,837 (335)
A conditional marker gene allowing both positive and negative selection in plants [PDF]
, 2004 Selectable markers enable transgenic plants or cells to be identified after transformation. They can be divided into positive and negative markers conferring a selective advantage or disadvantage, respectively.
Erikson, Oskar +2 more
core +1 more source
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Clinical and Experimental Obstetrics & GynecologyBackground: Intrahepatic cholestasis of pregnancy (ICP) and hyperemesis gravidarum (HEG) are pregnancy-specific liver diseases associated with significant fetal and maternal complications.
Ayça Kubat Küçükyurt +1 more
doaj +1 more source
Alanine Enhances Aminoglycosides-Induced ROS Production as Revealed by Proteomic Analysis
Frontiers in Microbiology, 2018 Metabolite-enabled killing of antibiotic-resistant pathogens by antibiotics is an attractive strategy to manage antibiotic resistance. Our previous study demonstrated that alanine or/and glucose increased the killing efficacy of kanamycin on antibiotic ...
Jin-zhou Ye +9 more
doaj +1 more source
Ab initio study of alanine polypeptide chains twisting
, 2005 We have investigated the potential energy surfaces for alanine chains consisting of three and six amino acids. For these molecules we have calculated potential energy surfaces as a function of the Ramachandran angles Phi and Psi, which are widely used ...
A. D. MacKerell +13 more
core +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Effect of the nitrogen source on glutamine and alanine biosynthesis in Neurospora crassa. An in vivo 15N nuclear magnetic resonance study [PDF]
, 1982 The influences of different nitrogen sources on the relative rates of biosynthesis of glutamine and alanine have been studied by 15N nuclear magnetic resonance spectroscopy of intact Neurospora crassa mycelia suspensions.
Kanamori, Keiko +3 more
core
Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity
Molecular Oncology, EarlyView.Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek +2 more
wiley +1 more source
Selected amino acids uptake by microorganisms in soil of differently managed mountain meadows
Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2011 This work was aimed at determination of the effect of 13 years abandonment of previously long-term mown mountain meadows on uptake of L-glutamic acid (14CO2H[14CH2]2[NH2]14CO2H) and L-alanine (14CH314CH[NH2]14CO2H) by microbial community of Ap horizon (3–
Valerie Vranová +4 more
doaj +1 more source
Jurnal Kedokteran Gigi Universitas Padjadjaran, 2021 Pendahuluan: Sutra cocoon laba-laba merupakan bahan alternatif yang diketahui sering digunakan oleh masyarakat tradisional untuk menghentikan pendarahan dan menutup luka.
Nadie Fatimatuzzahro +2 more
doaj +1 more source